PDB ID 6NJZ     CHAIN A
Protein name Ephrin type-A receptor 2
Uniprot Accession P29317
The number of similar proteins 18
The number of binding states 7
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
6NJZ (CHAIN: A)
1 Monomeric state
2 P20827  
3 P03212   P03231  
4 Q98142   Q76RG7  
5 P29317   P29317  
6 3SKJ   3SKJ  
7 Q76RG7   Q98142  

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Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MASQGPGEVV   LLDFAAAGGE   LGWLTHPYGK   GWDLMQNIMN   DMPIYMYSVC   50
51   NVMSGDQDNW   LRTNWVYRGE   AERIFIELKF   TVRDCNSFPG   GASSCKETFN   100
101   LYYAESDLDY   GTNFQKRLFT   KIDTIAPDEI   TVSSDFEARH   VKLNVEERSV   150
151   GPLTRKGFYL   AFQDIGACVA   LLSVRVYYKK   AHHHHHH     200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
40_GLU VAL 8.3kJPN
chr1:16477425 		rs1557516913
- 0.0003 -
41_LEU VAL gnomAD
chr1:16477423 		rs147977279
- 0.00201257 -
93_ARG CYS gnomAD
chr1:16475419 		rs200152244
- 0.000350026 -
99_LYS ASN VAR_055989 rs1058372
LB/B - -
104_ASP GLY 8.3kJPN
chr1:16475385 		-
- 0.0001 -
104_ASP TYR 8.3kJPN
chr1:16475386 		-
- 0.0001 -
150_ILE LEU 8.3kJPN
chr1:16475248 		-
- - -
156_PHE LEU 8.3kJPN
chr1:16475228 		-
- 0.0001 -
157_GLU LYS 8.3kJPN
chr1:16475227 		rs764156192
- 0.0001 -
165_VAL MET gnomAD
chr1:16475203 		rs150790360
- 0.00137229 -
165_VAL MET 8.3kJPN
chr1:16475203 		rs150790360
- 0.0001 -
172_PRO LEU gnomAD
chr1:16475181 		rs751025996
- 0.000156264 -
175_ARG CYS gnomAD
chr1:16475173 		rs147352564
- 0.000385415 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.