PDB ID 5WSV     CHAIN A
Protein name Calmodulin
Uniprot Accession P62158
The number of similar proteins 206
The number of binding states 37
The number of binding partners 27

Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GPGSMADQLT   EEQIAEFKEA   FSLFDKDGDG   TITTKELGTV   MRSLGQNPTE   50
51   AELQDMINEV   DADGNGTIDF   PEFLTMMARK   MKDTDSEEEI   REAFRVFDKD   100
101   GNGYISAAEL   RHVMTNLGEK   LTDEEVDEMI   READIDGDGQ   VNYEEFVQMM   150
151   T           200

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
29_THR PRO ClinVar
chr14:90867656
rs1057521851
Likely pathogenic - not provided [MedGen:CN517202]
29_THR SER 4.7kJPN
chr10:5567136
-
- 0.0001 -
31_GLU GLN 4.7kJPN
chr10:5567142
rs2231420
- 0.0337 -
53_ASN ILE ClinVar
chr14:90867729
rs267607276
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
89_PHE LEU ClinVar
chr14:90870295
rs730882253
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
90_ARG HIS 4.7kJPN
chr10:5567320
rs776439000
- 0.0018 -
93_ASP ALA ClinVar
chr19:47111841
rs1060502608
Pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
95_ASP VAL ClinVar
chr2:47388996
rs730882254
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
97_ASN SER ClinVar
chr14:90870730
rs267607277
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia [MedGen:C1631597,Orphanet:ORPHA3286]; Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
97_ASN SER ClinVar
chr2:47388990
rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
97_ASN ILE ClinVar
chr2:47388990
rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
104_GLU LYS ClinVar
chr14:90870750
rs1057523130
Likely pathogenic - not provided [MedGen:CN517202]
120_GLU LYS 4.7kJPN
chr10:5567409
-
- 0.0001 -
126_ARG SER 4.7kJPN
chr19:47112198
-
- 0.0001 -
127_ALA ASP 4.7kJPN
chr10:5567431
-
- 0.0001 -
128_ALA VAL 4.7kJPN
chr10:5567434
rs752809700
- 0.0003 -
129_ASP GLY ClinVar
chr14:90870826
rs730882252
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
129_ASP ASN 4.7kJPN
chr10:5567436
rs777995357
- 0.0003 -
129_ASP GLU 4.7kJPN
chr10:5567438
rs751753306
- 0.0003 -
131_ASP GLU ClinVar
chr2:47388887
rs398124648
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
131_ASP GLY ClinVar
chr19:47112212
rs1057523474
Likely pathogenic - not provided [MedGen:CN517202]
131_ASP GLU ClinVar
chr19:47112213
rs1064796271
Pathogenic - not provided [MedGen:CN517202]
132_GLY GLU ClinVar
chr14:90870835
rs1555366045
Likely pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
133_ASP HIS ClinVar
chr2:47388883
rs398124650
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
135_GLN PRO ClinVar
chr2:47388876
rs398124649
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
137_ASN LYS ClinVar
chr2:47388869
rs1553431702
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
139_GLU VAL ClinVar
chr14:90870856
rs1064793078
Likely pathogenic - not provided [MedGen:CN517202]
140_GLU GLY ClinVar
chr19:47112382
rs1555814427
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
141_PHE LEU ClinVar
chr14:90871037
rs199744595
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
141_PHE LEU ClinVar
chr14:90871035
rs1085307479
Likely pathogenic - not provided [MedGen:CN517202]
144_MET ARG ClinVar
chr2:47387931
-
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.