PDB ID 5KDM     CHAIN A
Protein name Histone H3.3
Uniprot Accession P84243
The number of similar proteins 310
The number of binding states 16
The number of binding partners 12

Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   ARTKQTARKS   TGGKAPRKQL   ATKAARKSAP   STGGVKKPHR   YRPGTVALRE   50
51   IRRYQKSTEL   LIRKLPFQRL   VREIAQDFKT   DLRFQSAAIG   ALQEASEAYL   100
101   VGLFEDTNLC   AIHAKRVTIM   PKDIQLARRI   RGERA     150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
39_HIS PRO 4.7kJPN
chr12:31944985
rs3759295
- 0.1261 -
40_ARG HIS 4.7kJPN
chr6:27839972
rs759503770
- 0.0001 -
42_ARG HIS 4.7kJPN
chr6:26045766
rs1042668277
- 0.0001 -
42_ARG TRP 4.7kJPN
chr12:31944977
rs368361217
- 0.0001 -
52_ARG TRP 4.7kJPN
chr1:149785080
rs200122276
- 0.0034 -
52_ARG HIS 4.7kJPN
chr1:228612869
rs201904037
- 0.0003 -
52_ARG HIS 4.7kJPN
chr6:26045796
-
- 0.0001 -
53_ARG HIS 4.7kJPN
chr1:149785076
rs782807753
- 0.0048 -
53_ARG SER 4.7kJPN
chr1:149785077
rs781886522
- 0.0001 -
53_ARG HIS 4.7kJPN
chr6:26020878
rs1343210635
- 0.0001 -
54_TYR HIS 4.7kJPN
chr6:26045801
-
- 0.0002 -
55_GLN TER 4.7kJPN
chr6:26020883
rs138229455
- 0.0001 -
58_THR ALA 4.7kJPN
chr6:26020892
rs144238254
- 0.0001 -
61_LEU PHE 4.7kJPN
chr6:26020901
rs1026102996
- 0.0001 -
62_ILE VAL 4.7kJPN
chr6:26271426
rs889798197
- 0.0001 -
63_ARG CYS 4.7kJPN
chr1:228612837
rs201294185
- 0.0036 -
66_PRO LEU 4.7kJPN
chr6:26020917
rs143364138
- 0.0131 -
66_PRO LEU 4.7kJPN
chr6:26250634
rs768039332
- 0.0004 -
66_PRO LEU 4.7kJPN
chr6:26271413
rs756545644
- 0.0001 -
66_PRO LEU 4.7kJPN
chr6:27778051
rs769595845
- 0.0001 -
67_PHE LEU 4.7kJPN
chr1:228612823
rs144064739
- 0.0096 -
67_PHE TYR 4.7kJPN
chr1:228612824
rs148655394
- 0.0096 -
67_PHE LEU 4.7kJPN
chr6:26045842
-
- 0.0001 -
68_GLN TER 4.7kJPN
chr6:26020922
rs181930473
- 0.0021 -
71_MET VAL 4.7kJPN
chr1:228612813
rs1222575419
- 0.0001 -
71_VAL MET 4.7kJPN
chr6:26045852
-
- 0.0001 -
71_VAL LEU 4.7kJPN
chr6:26250620
-
- 0.0001 -
72_ARG SER 4.7kJPN
chr1:228612810
rs148579172
- 0.0001 -
72_ARG TER 4.7kJPN
chr6:26225599
rs556601521
- 0.0001 -
72_ARG SER 4.7kJPN
chr6:26250617
-
- 0.0001 -
72_ARG GLN 4.7kJPN
chr6:26271395
-
- 0.0001 -
74_ILE THR 4.7kJPN
chr12:31944880
rs765335300
- 0.0009 -
75_ALA THR 4.7kJPN
chr1:149785011
-
- 0.0001 -
76_GLN TER 4.7kJPN
chr1:228612798
-
- 0.0001 -
79_LYS TER 4.7kJPN
chr6:26271375
rs1390395268
- 0.0015 -
82_LEU PHE 4.7kJPN
chr6:27778100
-
- 0.0001 -
83_ARG PRO 4.7kJPN
chr1:149784986
-
- 0.0002 -
85_GLN HIS 4.7kJPN
chr6:26250576
-
- 0.0001 -
85_GLN ARG 4.7kJPN
chr12:31944847
-
- 0.0001 -
86_SER ARG 4.7kJPN
chr6:27778112
-
- 0.0002 -
88_ALA SER 4.7kJPN
chr1:228612762
-
- 0.0002 -
90_MET LYS 4.7kJPN
chr6:26197207
-
- 0.0004 -
90_MET THR 4.7kJPN
chr6:26271341
rs759342007
- 0.0001 -
91_ALA THR 4.7kJPN
chr12:31944830
rs928601270
- 0.0001 -
95_ALA VAL 4.7kJPN
chr6:26045925
rs752518862
- 0.0001 -
96_CYS SER 4.7kJPN
chr1:228612738
-
- 0.0001 -
96_CYS SER 4.7kJPN
chr6:27778140
rs1250265926
- 0.0001 -
98_SER ALA 4.7kJPN
chr1:228612732
-
- 0.0001 -
98_ALA VAL 4.7kJPN
chr6:26021013
rs748134309
- 0.0002 -
100_LEU PHE 4.7kJPN
chr6:26031986
-
- 0.0002 -
104_PHE SER 4.7kJPN
chr6:26225696
-
- 0.0001 -
108_ASN SER 4.7kJPN
chr6:26045964
-
- 0.0001 -
111_VAL ALA 4.7kJPN
chr1:228612692
rs367745564
- 0.0001 -
114_ALA GLY 4.7kJPN
chr1:226259113
rs749423281
- 0.0076 -
114_ALA SER 4.7kJPN
chr6:26250491
-
- 0.0001 -
117_VAL LEU 4.7kJPN
chr1:149784885
-
- 0.0001 -
119_ILE VAL 4.7kJPN
chr6:26031931
rs1362284538
- 0.0001 -
119_ILE VAL 4.7kJPN
chr6:27858213
-
- 0.0001 -
120_MET ILE 4.7kJPN
chr6:26250471
-
- 0.0001 -
124_ILE PHE 4.7kJPN
chr6:26021090
rs199573090
- 0.0071 -
124_ILE MET 4.7kJPN
chr12:31944729
rs758582920
- 0.0002 -
125_GLN ARG ClinVar
chr1:226259146
rs1276519904
Likely pathogenic - H3F3A-related condition [na]; Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
126_LEU PHE 4.7kJPN
chr6:27778230
rs751190554
- 0.0002 -
127_ALA SER 4.7kJPN
chr1:149784855
-
- 0.0001 -
129_ARG PRO 4.7kJPN
chr6:27839705
-
- 0.0001 -
129_ARG GLN 4.7kJPN
chr12:31944715
rs147097287
- 0.0002 -
132_GLY TRP 4.7kJPN
chr6:27839697
rs749470205
- 0.0001 -
134_ARG SER 4.7kJPN
chr6:27778256
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.