PDB ID 5HXB     CHAIN Z
Protein name Protein cereblon
Uniprot Accession Q96SW2
The number of similar proteins 10
The number of binding states 6
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
5HXB (CHAIN: Z)
1 Q16531   P15170  
2 Q16531  
3 O60885   Q16531  
4 Q16531   Q9BU19  
5 Q16531   6H0F  
6 Q16531   P48729  

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Molecule viewer

#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GSMEAKKPNI   INFDTSLPTS   HTYLGADMEE   FHGRTLHDDD   SCQVIPVLPQ   50
51   VMMILIPGQT   LPLQLFHPQE   VSMVRNLIQK   DRTFAVLAYS   NVQEREAQFG   100
101   TTAEIYAYRE   EQDFGIEIVK   VKAIGRQRFK   VLELRTQSDG   IQQAKVQILP   150
151   ECVLPSTMSA   VQLESLNKCQ   IFPSKPVSRE   DQCSYKWWQK   YQKRKFHCAN   200
201   LTSWPRWLYS   LYDAETLMDR   IKKQLREWDE   NLKDDSLPSN   PIDFSYRVAA   250
251   CLPIDDVLRI   QLLKIGSAIQ   RLRCELDIMN   KCTSLCCKQC   QETEITTKNE   300
301   IFSLSLCGPM   AAYVNPHGYV   HETLTVYKAC   NLNLIGRPST   EHSWFPGYAW   350
351   TVAQCKICAS   HIGWKFTATK   KDMSPQKFWG   LTRSALLPTI   PDTEDEISPD   400
401   KVILCL           450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
54_PRO LEU 4.7kJPN
chr3:3216860
-
- 0.0001 -
60_LEU VAL 4.7kJPN
chr3:3215942
-
- 0.0001 -
89_MET ILE 4.7kJPN
chr3:3215853
rs760055652
- 0.0006 -
111_ARG GLN 4.7kJPN
chr3:3215788
rs151127854
- 0.0001 -
301_ILE THR 4.7kJPN
chr3:3195693
rs758001907
- 0.0001 -
316_ASN HIS 4.7kJPN
chr3:3195649
-
- 0.0001 -
347_ALA VAL 4.7kJPN
chr3:3194248
-
- 0.0001 -
373_ARG GLN 4.7kJPN
chr3:3194170
rs573677293
- 0.0005 -
391_CYS ARG VAR_079409 rs797045036
Disease - Mental retardation, autosomal recessive 2A (MRT2A) [MIM:607417]
391_CYS ARG ClinVar
chr3:3192707
rs797045036
Likely pathogenic - Mental retardation, autosomal recessive 2 [MedGen:C1843942,OMIM:607417]; not provided [MedGen:CN517202]
411_PRO HIS 4.7kJPN
chr3:3192646
-
- 0.0002 -
411_PRO SER 4.7kJPN
chr3:3192647
-
- 0.0001 -
418_THR MET 4.7kJPN
chr3:3192625
rs1367633045
- 0.0001 -
419_ARG TER ClinVar
chr3:3192623
rs121918368
Pathogenic - Mental retardation, autosomal recessive 2 [MedGen:C1843942,OMIM:607417]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.