PDB ID 5FUC     CHAIN A
Protein name INTERLEUKIN-6
Uniprot Accession P05231
The number of similar proteins 13
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5FUC (CHAIN: A)
1 5FUC   D6R9R8  
2 Monomeric state
3 P05231  
4 A4L9V2  
5 4CNI   4CNI  
6 4ZS7   4ZS7  
7 P08887   P40189  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GSSSERIDKQ   IRYILDGISA   LRKETCNKSN   MCESSKEALA   ENNLNLPKMA   50
51   EKDGCFQSGF   NEETCLVKII   TGLLEFEVYL   EYLQNRFESS   EEQARAVQMS   100
101   TKVLIQFLQK   KAKNLDAITT   PDPTTNASLL   TKLQAQNQWL   QDMTTHLILR   150
151   SFKEFLQSSL   RALRQM         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
49_MET THR 8.3kJPN
chr7:22768331 		rs775325818
- 0.0001 -
130_ALA SER 8.3kJPN
chr7:22771025 		-
- 0.0001 -
134_ASP VAL VAR_013076 rs2069860
LB/B - -
134_ASP GLU VAR_029266 rs13306435
LB/B - -
134_ASP VAL gnomAD
chr7:22771038 		rs2069860
- 0.00596655 -
134_ASP GLU gnomAD
chr7:22771039 		rs13306435
- 0.0286538 -
134_ASP GLU 8.3kJPN
chr7:22771039 		rs13306435
- 0.0315 -
143_THR ALA 8.3kJPN
chr7:22771064 		-
- 0.0001 -
154_GLN GLU 8.3kJPN
chr7:22771097 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.