PDB ID 4P6Z     CHAIN B
Protein name AP-1 complex subunit beta-1
Uniprot Accession Q10567
The number of similar proteins 7
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
4P6Z (CHAIN: B)
1 P35585   P22892  
2 P84092   P17427  
3 P35585   1W63   P61967  
4 P84092   P62743   Q66HM2  

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Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MGSSHHHHHH   SQDPNSMTDS   KYFTTTKKGE   IFELKAELNS   DKKEKKKEAV   50
51   KKVIASMTVG   KDVSALFPDV   VNCMQTDNLE   LKKLVYLYLM   NYAKSQPDMA   100
101   IMAVNTFVKD   CEDPNPLIRA   LAVRTMGCIR   VDKITEYLCE   PLRKCLKDED   150
151   PYVRKTAAVC   VAKLHDINAQ   LVEDQGFLDT   LKDLISDSNP   MVVANAVAAL   200
201   SEIAESHPSS   NLLDLNPQSI   NKLLTALNEC   TEWGQIFILD   CLANYMPKDD   250
251   REAQSICERV   TPRLSHANSA   VVLSAVKVLM   KFMEMLSKDL   DYYGTLLKKL   300
301   APPLVTLLSA   EPELQYVALR   NINLIVQKRP   EILKHEMKVF   FVKYNDPIYV   350
351   KLEKLDIMIR   LASQANIAQV   LAELKEYATE   VDVDFVRKAV   RAIGRCAIKV   400
401   EQSAERCVST   LLDLIQTKVN   YVVQEAIVVI   KDIFRKYPNK   YESVIAALCE   450
451   NLDSLDEPEA   RAAMIWIVGE   YAERIDNADE   LLESFLEGFH   DKSTQVQLQL   500
501   LTAIVKLFLK   KPTETQELVQ   QVLSLATQDS   DNPDLRDRGY   IYWRLLSTDP   550
551   VAAKEVVLAE   KPLISEETDL   IEPTLLDELI   CYIGTLASVY   HKPPSAFVEG   600

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
22_LEU PHE 4.7kJPN
chr22:29759069
-
- 0.0001 -
86_MET LEU 4.7kJPN
chr22:29755836
-
- 0.0001 -
114_ARG GLN 4.7kJPN
chr17:33935222
-
- 0.0001 -
141_ALA VAL 4.7kJPN
chr22:29754818
-
- 0.0001 -
155_LEU MET 4.7kJPN
chr22:29754777
-
- 0.0001 -
204_ILE VAL 4.7kJPN
chr22:29752521
-
- 0.0001 -
205_ASN SER 4.7kJPN
chr22:29752517
rs772647244
- 0.0002 -
212_ASN LYS 4.7kJPN
chr22:29752495
-
- 0.0001 -
235_ARG HIS 4.7kJPN
chr22:29752427
rs140871358
- 0.0001 -
271_SER PRO 4.7kJPN
chr22:29750766
-
- 0.0001 -
273_ASP TYR 4.7kJPN
chr17:33953740
-
- 0.0001 -
285_ALA SER 4.7kJPN
chr22:29750724
-
- 0.0001 -
307_ASN SER 4.7kJPN
chr22:29750657
rs747391498
- 0.0001 -
323_VAL MET 4.7kJPN
chr22:29747786
-
- 0.0001 -
390_ARG HIS 4.7kJPN
chr22:29746126
rs754230380
- 0.0001 -
396_LEU PHE 4.7kJPN
chr22:29746109
-
- 0.0001 -
415_LYS ARG 4.7kJPN
chr22:29746051
-
- 0.0001 -
415_LYS GLN 4.7kJPN
chr22:29746052
-
- 0.0001 -
426_GLU GLY 4.7kJPN
chr17:33966619
-
- 0.0002 -
427_SER GLY 4.7kJPN
chr17:33966621
-
- 0.0001 -
434_GLU LYS 4.7kJPN
chr22:29745344
rs759728681
- 0.0001 -
435_ASN ASP 4.7kJPN
chr22:29745341
-
- 0.0001 -
448_MET VAL 4.7kJPN
chr17:33966684
-
- 0.0002 -
462_ALA PRO 4.7kJPN
chr17:33966726
-
- 0.0001 -
476_GLU LYS 4.7kJPN
chr22:29745218
rs576191808
- 0.0001 -
534_PRO THR 4.7kJPN
chr22:29737686
rs750013781
- 0.0002 -
542_LEU PHE 4.7kJPN
chr22:29737660
-
- 0.0001 -
543_ALA SER 4.7kJPN
chr22:29737659
rs751837097
- 0.0001 -
561_ASP GLU 4.7kJPN
chr22:29737603
rs560553452
- 0.0001 -
566_TYR HIS 4.7kJPN
chr22:29737590
rs756098869
- 0.0003 -
568_GLY SER 4.7kJPN
chr22:29737584
rs371236685
- 0.0002 -
569_THR SER 4.7kJPN
chr22:29737581
-
- 0.0001 -
579_SER GLY 4.7kJPN
chr22:29737551
rs200628910
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.