PDB ID 4FQX     CHAIN B
Protein name HLA class II histocompatibility antigen, DRB1-1 beta chain
Uniprot Accession P04229
The number of similar proteins 97
The number of binding states 19
The number of binding partners 9

Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   VLFQGPGDTR   PRFLWQLKFE   CHFFNGTERV   RLLERSIYNQ   EESVRFDSDV   50
51   GEYRAVTELG   RPDAEYWNSQ   KDLLEQRRAA   VDTYCRHNYG   VGESFTVQRR   100
101   VEPKVTVYPS   KTQPLQHHNL   LVCSVSGFYP   GSIEVRWFRN   GQEEKAGVVS   150
151   TGLIQNGDWT   FQTLVMLETV   PRSGEVYTCQ   VEHPSVTSPL   TVEWRARSSG   200
201   GGSLPATG           250

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
1_GLY VAL 4.7kJPN
chr6:32497913
rs146966122
- 0.0784 -
1_GLY ARG 4.7kJPN
chr6:32497914
rs76748970
- 0.3056 -
1_GLY VAL 4.7kJPN
chr6:32557431
rs761074986
- 0.0717 -
2_ASP GLY 4.7kJPN
chr6:32497910
rs139583918
- 0.095 -
2_ASP GLU 4.7kJPN
chr6:32557427
-
- 0.0001 -
2_ASP GLY 4.7kJPN
chr6:32557428
rs201700261
- 0.1087 -
3_THR PRO 4.7kJPN
chr6:32497908
rs796754225
- 0.0028 -
3_THR PRO 4.7kJPN
chr6:32557426
rs749376442
- 0.0015 -
4_ARG GLN VAR_033380 rs1141741
Polymorphism - -
4_ARG GLN 4.7kJPN
chr6:32497904
rs1141741
- 0.1558 -
4_ARG GLN 4.7kJPN
chr6:32557422
rs17879746
- 0.2665 -
6_ARG CYS 4.7kJPN
chr6:32489949
rs1136744
- 0.013 -
9_GLN ARG 4.7kJPN
chr6:32489939
rs17433849
- 0.004 -
9_TRP TER 4.7kJPN
chr6:32552143
rs9269958
- 0.5054 -
9_TRP GLY 4.7kJPN
chr6:32552144
rs9269959
- 0.4454 -
10_GLN GLU VAR_016740 -
Polymorphism - -
10_GLN LEU 4.7kJPN
chr6:32489936
rs201948867
- 0.045 -
10_GLN GLU 4.7kJPN
chr6:32489937
rs200071340
- 0.0081 -
10_GLN LEU 4.7kJPN
chr6:32552140
rs17882663
- 0.1425 -
11_ASP HIS 4.7kJPN
chr6:32489934
rs1136752
- 0.0476 -
12_LYS THR 4.7kJPN
chr6:32489930
rs200581589
- 0.0162 -
12_LYS THR 4.7kJPN
chr6:32552134
rs1136756
- 0.2881 -
13_TYR HIS 4.7kJPN
chr6:32489928
rs1136757
- 0.2349 -
13_ARG SER 4.7kJPN
chr6:32552130
rs9269951
- 0.7557 -
14_GLU LYS 4.7kJPN
chr6:32489925
rs17405212
- 0.0035 -
16_HIS TYR 4.7kJPN
chr6:32489919
rs199680107
- 0.0067 -
16_HIS GLN 4.7kJPN
chr6:32552121
rs17879981
- 0.0168 -
16_HIS TYR 4.7kJPN
chr6:32552123
rs17879702
- 0.1644 -
18_PHE LEU 4.7kJPN
chr6:32489913
rs201628145
- 0.0382 -
18_PHE LEU 4.7kJPN
chr6:32552117
rs114435757
- 0.2389 -
22_GLU GLN 4.7kJPN
chr6:32552105
-
- 0.0002 -
23_ARG LEU 4.7kJPN
chr6:32552101
-
- 0.0001 -
24_VAL GLU 4.7kJPN
chr6:32552098
rs1335931724
- 0.0011 -
25_ARG GLN 4.7kJPN
chr6:32489891
rs112906420
- 0.0015 -
25_ARG TRP 4.7kJPN
chr6:32489892
rs184278615
- 0.0493 -
25_ARG GLN 4.7kJPN
chr6:32552095
rs17885382
- 0.0016 -
25_ARG TRP 4.7kJPN
chr6:32552096
rs188617679
- 0.2403 -
26_PHE TYR 4.7kJPN
chr6:32489888
rs147440497
- 0.3041 -
26_PHE ILE 4.7kJPN
chr6:32489889
rs201469165
- 0.0509 -
26_PHE TYR 4.7kJPN
chr6:32552092
rs1059569
- 0.3569 -
26_PHE ILE 4.7kJPN
chr6:32552093
rs201128876
- 0.195 -
28_HIS LEU 4.7kJPN
chr6:32489882
rs200298678
- 0.0532 -
28_ASP VAL 4.7kJPN
chr6:32552086
rs200532329
- 0.2402 -
30_TYR HIS 4.7kJPN
chr6:32552081
rs11554462
- 0.1205 -
32_TYR HIS 4.7kJPN
chr6:32489871
rs137863146
- 0.0435 -
32_TYR HIS 4.7kJPN
chr6:32552075
rs1064664
- 0.2463 -
33_ASN HIS 4.7kJPN
chr6:32489868
rs1059576
- 0.189 -
33_ASN THR 4.7kJPN
chr6:32552071
-
- 0.0002 -
33_ASN HIS 4.7kJPN
chr6:32552072
rs17879995
- 0.1222 -
37_SER TYR VAR_033381 rs16822820
Polymorphism - -
37_SER THR 4.7kJPN
chr6:32552060
rs16822820
- 0.0911 -
38_LEU SER 4.7kJPN
chr6:32489852
rs192498095
- 0.0774 -
38_VAL ALA 4.7kJPN
chr6:32552056
rs17878951
- 0.2976 -
38_VAL LEU 4.7kJPN
chr6:32552057
rs17878614
- 0.0573 -
40_PHE TYR 4.7kJPN
chr6:32489846
rs150479833
- 0.0623 -
40_PHE TYR 4.7kJPN
chr6:32552050
rs17882455
- 0.2427 -
40_PHE VAL 4.7kJPN
chr6:32552051
-
- 0.0002 -
41_ASP ASN 4.7kJPN
chr6:32489844
rs140580884
- 0.0607 -
41_ASP ASN 4.7kJPN
chr6:32552048
rs56158521
- 0.3231 -
42_SER GLY 4.7kJPN
chr6:32489841
-
- 0.0001 -
45_GLY ARG VAR_016741 -
Polymorphism - -
45_GLY ARG 4.7kJPN
chr6:32552036
rs17885437
- 0.0001 -
47_TYR PHE 4.7kJPN
chr6:32489825
rs148834340
- 0.0407 -
47_PHE TYR 4.7kJPN
chr6:32552029
rs17884945
- 0.5242 -
48_ARG GLN 4.7kJPN
chr6:32489822
rs115417906
- 0.0469 -
48_ARG GLN 4.7kJPN
chr6:32552026
rs17886436
- 0.2436 -
51_THR ARG 4.7kJPN
chr6:32489813
rs79606458
- 0.0113 -
51_THR ARG 4.7kJPN
chr6:32552017
rs1059582
- 0.0503 -
57_ASP ASN 4.7kJPN
chr6:32489796
rs145586726
- 0.1773 -
57_ASP ASN 4.7kJPN
chr6:32552000
rs17880292
- 0.1097 -
58_ALA ASP 4.7kJPN
chr6:32489792
rs41562816
- 0.0252 -
58_ALA ASP 4.7kJPN
chr6:32551996
rs1059584
- 0.0034 -
60_TYR SER VAR_033383 rs1059586
Polymorphism - -
60_TYR SER 4.7kJPN
chr6:32489786
rs41541218
- 0.1511 -
60_TYR ASP 4.7kJPN
chr6:32489787
-
- 0.0002 -
60_TYR SER 4.7kJPN
chr6:32551990
rs1059586
- 0.1056 -
60_TYR HIS 4.7kJPN
chr6:32551991
rs17882583
- 0.0396 -
61_TRP ARG 4.7kJPN
chr6:32551988
-
- 0.0001 -
67_LEU ILE VAR_016710 -
Polymorphism - -
69_GLU ALA 4.7kJPN
chr6:32489759
rs764618537
- 0.0005 -
69_GLU TER 4.7kJPN
chr6:32551964
-
- 0.0001 -
70_GLN ASP VAR_016711 -
Polymorphism - -
70_GLN GLU VAR_033384 rs17881965
Polymorphism - -
70_GLN HIS VAR_033385 rs17879599
Polymorphism - -
71_ARG GLU VAR_016712 -
Polymorphism - -
71_ARG ALA VAR_016742 -
Polymorphism - -
71_ARG LYS 4.7kJPN
chr6:32489753
rs41544215
- 0.0233 -
71_ARG GLY 4.7kJPN
chr6:32489754
rs41551116
- 0.0426 -
71_ALA THR 4.7kJPN
chr6:32551958
rs1064592
- 0.3337 -
72_ARG TRP 4.7kJPN
chr6:32551955
rs17885222
- 0.0013 -
73_ALA GLY VAR_033386 rs17878857
Polymorphism - -
74_ALA GLU VAR_033387 rs16822805
Polymorphism - -
74_ALA PRO 4.7kJPN
chr6:32489745
rs41548618
- 0.218 -
76_ASP GLY 4.7kJPN
chr6:32489738
rs776845219
- 0.0003 -
76_ASP GLY 4.7kJPN
chr6:32551942
rs767943289
- 0.0112 -
77_THR ASN VAR_016713 -
Polymorphism - -
77_THR ASN 4.7kJPN
chr6:32489735
rs115817940
- 0.0706 -
77_THR ASN 4.7kJPN
chr6:32551939
rs9269941
- 0.1643 -
78_TYR HIS VAR_033388 rs16822512
Polymorphism - -
78_TYR PHE 4.7kJPN
chr6:32489732
rs1064677
- 0.1007 -
78_TYR ASP 4.7kJPN
chr6:32489733
rs1064595
- 0.1009 -
78_TYR ASP 4.7kJPN
chr6:32551937
rs17884043
- 0.0003 -
80_ARG LYS 4.7kJPN
chr6:32489726
-
- 0.0001 -
81_HIS TYR 4.7kJPN
chr6:32489724
rs142908883
- 0.0079 -
81_HIS TYR 4.7kJPN
chr6:32551928
rs29029549
- 0.298 -
85_VAL ALA VAR_016714 rs17424145
Polymorphism - -
85_VAL ALA 4.7kJPN
chr6:32489711
rs1136778
- 0.0106 -
85_VAL ALA 4.7kJPN
chr6:32551915
rs17424145
- 0.0397 -
86_GLY VAL VAR_016715 -
Polymorphism - -
86_GLY VAL 4.7kJPN
chr6:32489708
rs41556512
- 0.0158 -
86_VAL GLY 4.7kJPN
chr6:32551912
rs17885482
- 0.2238 -
89_PHE LEU 4.7kJPN
chr6:32489700
-
- 0.0001 -
104_ALA VAL 4.7kJPN
chr6:32487401
rs758743151
- 0.004 -
104_ALA SER 4.7kJPN
chr6:32487402
rs114131132
- 0.0161 -
104_SER LEU 4.7kJPN
chr6:32549588
rs201929247
- 0.2707 -
104_SER ALA 4.7kJPN
chr6:32549589
rs2308760
- 0.3853 -
120_ASN SER 4.7kJPN
chr6:32487353
rs114293611
- 0.2823 -
120_SER ASN 4.7kJPN
chr6:32549540
rs1059351
- 0.2946 -
123_TYR CYS 4.7kJPN
chr6:32487344
rs201863832
- 0.0645 -
123_TYR CYS 4.7kJPN
chr6:32549531
rs112796209
- 0.2921 -
125_GLY ALA 4.7kJPN
chr6:32487338
rs113395425
- 0.0666 -
125_GLY ALA 4.7kJPN
chr6:32549525
rs16822698
- 0.293 -
127_ILE VAL 4.7kJPN
chr6:32487333
rs199986849
- 0.0894 -
127_ILE VAL 4.7kJPN
chr6:32549520
rs202047044
- 0.1931 -
133_ARG GLN 4.7kJPN
chr6:32487314
rs201882312
- 0.1496 -
135_GLY ASP VAR_033389 rs1059633
Polymorphism - -
135_SER GLY 4.7kJPN
chr6:32487309
rs1059633
- 0.7166 -
140_ALA THR 4.7kJPN
chr6:32487294
rs75709987
- 0.3022 -
140_ALA THR 4.7kJPN
chr6:32549481
rs78916069
- 0.3408 -
141_GLY VAL 4.7kJPN
chr6:32549477
-
- 0.0001 -
142_VAL MET VAR_033391 rs701829
Polymorphism - -
142_MET VAL 4.7kJPN
chr6:32549475
rs701829
- 0.8097 -
153_TRP TER 4.7kJPN
chr6:32549441
-
- 0.0001 -
157_THR ILE 4.7kJPN
chr6:32487242
rs41559420
- 0.011 -
159_VAL MET 4.7kJPN
chr6:32487237
rs192264100
- 0.1492 -
159_VAL MET 4.7kJPN
chr6:32549424
rs112116022
- 0.2231 -
166_ARG GLN VAR_033393 rs3205588
Polymorphism - -
166_ARG GLN 4.7kJPN
chr6:32487215
rs148933006
- 0.0699 -
166_ARG GLN 4.7kJPN
chr6:32549402
rs3205588
- 0.1722 -
168_GLY ALA 4.7kJPN
chr6:32487209
rs189435670
- 0.2558 -
168_GLY ALA 4.7kJPN
chr6:32549396
rs2308775
- 0.1382 -
172_THR SER 4.7kJPN
chr6:32549385
-
- 0.0001 -
175_VAL LEU 4.7kJPN
chr6:32487189
rs201575183
- 0.2592 -
175_VAL LEU 4.7kJPN
chr6:32549376
rs36044702
- 0.1287 -
176_GLU LYS 4.7kJPN
chr6:32487186
rs772100213
- 0.0003 -
181_THR MET 4.7kJPN
chr6:32487170
rs1136633
- 0.3507 -
181_THR ILE 4.7kJPN
chr6:32549357
rs200809587
- 0.3704 -
182_SER ARG 4.7kJPN
chr6:32487166
-
- 0.0001 -
183_PRO LEU 4.7kJPN
chr6:32487164
rs111541713
- 0.2655 -
183_PRO ALA 4.7kJPN
chr6:32487165
rs142204283
- 0.0264 -
183_PRO LEU 4.7kJPN
chr6:32549351
rs17885501
- 0.117 -
183_PRO ALA 4.7kJPN
chr6:32549352
rs1136846
- 0.0491 -
187_GLU GLN 4.7kJPN
chr6:32487153
rs112024745
- 0.11 -
187_GLU GLN 4.7kJPN
chr6:32549340
rs33936261
- 0.3094 -
189_ARG SER 4.7kJPN
chr6:32548632
rs1136881
- 0.2428 -
189_ARG GLY 4.7kJPN
chr6:32549334
-
- 0.0001 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.