PDB ID 4CLN     CHAIN A
Protein name CALMODULIN
Uniprot Accession P62152
The number of similar proteins 201
The number of binding states 36
The number of binding partners 26

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   ADQLTEEQIA   EFKEAFSLFD   KDGDGTITTK   ELGTVMRSLG   QNPTEAELQD   50
51   MINEVDADGN   GTIDFPEFLT   MMARKMKDTD   SEEEIREAFR   VFDKDGNGFI   100
101   SAAELRHVMT   NLGEKLTDEE   VDEMIREADI   DGDGQVNYEE   FVTMMTSK   150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
23_GLY GLU 8.3kJPN
chr10:5567119 		-
- 0.0001 -
29_THR PRO ClinVar
chr14:90867656 		rs1057521851
Likely pathogenic - not provided [MedGen:CN517202]
29_THR SER 8.3kJPN
chr10:5567136 		-
- 0.0001 -
31_GLU GLN gnomAD
chr10:5567142 		rs2231420
- 0.00532811 -
31_GLU GLN 8.3kJPN
chr10:5567142 		rs2231420
- 0.0341 -
51_MET VAL 8.3kJPN
chr10:5567202 		-
- 0.0001 -
53_ASN ILE ClinVar
chr14:90867729 		rs267607276
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
61_GLY SER gnomAD
chr10:5567232 		rs550418190
- 0.000502304 -
66_PRO SER gnomAD
chr10:5567247 		rs75808734
- 0.000394542 -
89_PHE LEU ClinVar
chr14:90870295 		rs730882253
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
90_ARG HIS 8.3kJPN
chr10:5567320 		rs776439000
- 0.0019 -
93_ASP ALA ClinVar
chr19:47111841 		rs1060502608
Pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
95_ASP VAL ClinVar
chr2:47388996 		rs730882254
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
96_GLY SER 8.3kJPN
chr10:5567337 		rs190000968
- 0.0002 -
97_ASN SER ClinVar
chr14:90870730 		rs267607277
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia [MedGen:C1631597,Orphanet:ORPHA3286]; Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
97_ASN SER ClinVar
chr2:47388990 		rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
97_ASN ILE ClinVar
chr2:47388990 		rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
104_GLU LYS ClinVar
chr14:90870750 		rs1057523130
Likely pathogenic - not provided [MedGen:CN517202]
120_GLU LYS 8.3kJPN
chr10:5567409 		-
- 0.0001 -
126_ARG TRP gnomAD
chr10:5567427 		rs754327442
- 0.000119868 -
128_ALA VAL 8.3kJPN
chr10:5567434 		rs752809700
- 0.0002 -
129_ASP GLY ClinVar
chr14:90870826 		rs730882252
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
129_ASP ASN 8.3kJPN
chr10:5567436 		rs777995357
- 0.0002 -
129_ASP GLU 8.3kJPN
chr10:5567438 		rs751753306
- 0.0002 -
130_THR ARG 8.3kJPN
chr10:5567440 		-
- 0.0001 -
131_ASP GLU ClinVar
chr2:47388887 		rs398124648
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
131_ASP GLY ClinVar
chr19:47112212 		rs1057523474
Likely pathogenic - not provided [MedGen:CN517202]
131_ASP GLU ClinVar
chr19:47112213 		rs1064796271
Pathogenic - not provided [MedGen:CN517202]
132_GLY GLU ClinVar
chr14:90870835 		rs1555366045
Likely pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
133_ASP HIS ClinVar
chr2:47388883 		rs398124650
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
135_GLN PRO ClinVar
chr2:47388876 		rs398124649
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
137_ASN LYS ClinVar
chr2:47388869 		rs1553431702
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
139_GLU VAL ClinVar
chr14:90870856 		rs1064793078
Likely pathogenic - not provided [MedGen:CN517202]
140_GLU GLY ClinVar
chr19:47112382 		rs1555814427
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
141_PHE LEU ClinVar
chr14:90871037 		rs199744595
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
141_PHE LEU ClinVar
chr14:90871035 		rs1085307479
Likely pathogenic - not provided [MedGen:CN517202]
144_MET ARG ClinVar
chr2:47387931 		-
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
144_VAL MET gnomAD
chr10:5567481 		rs530831313
- 0.000136752 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.