PDB ID 4CLN     CHAIN A
Protein name CALMODULIN
Uniprot Accession P62152
The number of similar proteins 201
The number of binding states 36
The number of binding partners 26

Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   ADQLTEEQIA   EFKEAFSLFD   KDGDGTITTK   ELGTVMRSLG   QNPTEAELQD   50
51   MINEVDADGN   GTIDFPEFLT   MMARKMKDTD   SEEEIREAFR   VFDKDGNGFI   100
101   SAAELRHVMT   NLGEKLTDEE   VDEMIREADI   DGDGQVNYEE   FVTMMTSK   150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
29_THR PRO ClinVar
chr14:90867656
rs1057521851
Likely pathogenic - not provided [MedGen:CN517202]
29_THR SER 4.7kJPN
chr10:5567136
-
- 0.0001 -
31_GLU GLN 4.7kJPN
chr10:5567142
rs2231420
- 0.0337 -
53_ASN ILE ClinVar
chr14:90867729
rs267607276
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
89_PHE LEU ClinVar
chr14:90870295
rs730882253
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
90_ARG HIS 4.7kJPN
chr10:5567320
rs776439000
- 0.0018 -
93_ASP ALA ClinVar
chr19:47111841
rs1060502608
Pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
95_ASP VAL ClinVar
chr2:47388996
rs730882254
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
97_ASN SER ClinVar
chr14:90870730
rs267607277
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia [MedGen:C1631597,Orphanet:ORPHA3286]; Catecholaminergic polymorphic ventricular tachycardia type 1 [MedGen:C4053736,OMIM:604772]; Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
97_ASN SER ClinVar
chr2:47388990
rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
97_ASN ILE ClinVar
chr2:47388990
rs398124647
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
104_GLU LYS ClinVar
chr14:90870750
rs1057523130
Likely pathogenic - not provided [MedGen:CN517202]
120_GLU LYS 4.7kJPN
chr10:5567409
-
- 0.0001 -
126_ARG SER 4.7kJPN
chr19:47112198
-
- 0.0001 -
127_ALA ASP 4.7kJPN
chr10:5567431
-
- 0.0001 -
128_ALA VAL 4.7kJPN
chr10:5567434
rs752809700
- 0.0003 -
129_ASP GLY ClinVar
chr14:90870826
rs730882252
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
129_ASP ASN 4.7kJPN
chr10:5567436
rs777995357
- 0.0003 -
129_ASP GLU 4.7kJPN
chr10:5567438
rs751753306
- 0.0003 -
131_ASP GLU ClinVar
chr2:47388887
rs398124648
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
131_ASP GLY ClinVar
chr19:47112212
rs1057523474
Likely pathogenic - not provided [MedGen:CN517202]
131_ASP GLU ClinVar
chr19:47112213
rs1064796271
Pathogenic - not provided [MedGen:CN517202]
132_GLY GLU ClinVar
chr14:90870835
rs1555366045
Likely pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]; Ventricular tachycardia, catecholaminergic polymorphic, 4 [MedGen:C3554047,OMIM:614916]
133_ASP HIS ClinVar
chr2:47388883
rs398124650
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
135_GLN PRO ClinVar
chr2:47388876
rs398124649
Pathogenic/Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]; Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
137_ASN LYS ClinVar
chr2:47388869
rs1553431702
Pathogenic - Long QT syndrome 15 [MedGen:C4015695,OMIM:616249]
139_GLU VAL ClinVar
chr14:90870856
rs1064793078
Likely pathogenic - not provided [MedGen:CN517202]
140_GLU GLY ClinVar
chr19:47112382
rs1555814427
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
141_PHE LEU ClinVar
chr14:90871037
rs199744595
Pathogenic - Long QT syndrome 14 [MedGen:C4015671,OMIM:616247]
141_PHE LEU ClinVar
chr14:90871035
rs1085307479
Likely pathogenic - not provided [MedGen:CN517202]
144_MET ARG ClinVar
chr2:47387931
-
Likely pathogenic - Long QT syndrome 1 [MedGen:C4551647,OMIM:192500,SNOMED CT:20852007]
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.