PDB ID 3W11     CHAIN E
Protein name Insulin receptor domains L1-CR
Uniprot Accession P06213
The number of similar proteins 10
The number of binding states 4
The number of binding partners 3

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3W11 (CHAIN: E)
1 6VEP   6VEP   P01308  
2 Monomeric state
3 P05019  
4 5J3H   5J3H  

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Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   HLYPGEVCPG   MDIRNNLTRL   HELENCSVIE   GHLQILLMFK   TRPEDFRDLS   50
51   FPKLIMITDY   LLLFRVYGLE   SLKDLFPNLT   VIRGSRLFFN   YALVIFEMVH   100
101   LKELGLYNLM   NITRGSVRIE   KNNELCYLAT   IDWSRILDSV   EDNHIVLNKD   150
151   DNEECGDICP   GTAKGKTNCP   ATVINGQFVE   RCWTHSHCQK   VCPTICKSHG   200
201   CTAEGLCCHS   ECLGNCSQPD   DPTKCVACRN   FYLDGRCVET   CPPPYYHFQD   250
251   WRCVNFSFCQ   DLHHKCKNSR   RQGCHQYVIH   NNKCIPECPS   GYTMNSSNLL   300
301   CTPCLGPCPK           350

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
15_ASN LYS VAR_004079
rs121913143
LP/P - 0.9737 Rabson-Mendenhall syndrome (RMS) [MIM:262190]
15_ASN LYS ClinVar
chr19:7267882
rs121913143
Pathogenic - 0.9737 Rabson-Mendenhall syndrome [MONDO:MONDO:0009874,MedGen:C0271695,OMIM:262190,Orphanet:769]
24_GLU LYS gnomAD
chr19:7267857
rs140852238
- 0.000453677 0.1027 -
28_VAL ALA VAR_004080
rs121913152
LP/P - 0.8064 Leprechaunism (LEPRCH) [MIM:246200]
28_VAL ALA ClinVar
chr19:7267844
rs121913152
Pathogenic - 0.8064 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
29_ILE THR VAR_079535
rs1555689937
LP/P - 0.9153 Leprechaunism (LEPRCH) [MIM:246200]
31_GLY ARG VAR_004081
rs52836744
LP/P - 0.9954 Leprechaunism (LEPRCH) [MIM:246200]
31_GLY ARG ClinVar
chr19:7267836
rs52836744
Pathogenic - 0.9954 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
59_ASP GLY VAR_015907
-
LP/P - 0.6861 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
62_LEU PRO VAR_015908
-
LP/P - 0.9992 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
65_ARG TRP 8.3kJPN
chr19:7267734
-
- 0.0001 0.9719 -
86_ARG PRO VAR_004082
rs121913153
LP/P - 0.9179 Leprechaunism (LEPRCH) [MIM:246200]
86_ARG PRO ClinVar
chr19:7267670
rs121913153
Pathogenic - 0.9179 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
92_ALA VAL VAR_015909
rs1347473020
LP/P - 0.9815 Leprechaunism (LEPRCH) [MIM:246200]
93_LEU GLN VAR_031518
-
LP/P - 0.9948 Leprechaunism (LEPRCH) [MIM:246200]
105_GLY SER ClinVar
chr19:7267614
rs886037750
Pathogenic - 0.5883 Rabson-Mendenhall syndrome [MONDO:MONDO:0009874,MedGen:C0271695,OMIM:262190,Orphanet:769]
118_ARG SER 8.3kJPN
chr19:7267575
-
- 0.0002 0.9978 -
119_ILE MET VAR_015539
rs121913159
LP/P - 0.2029 Leprechaunism (LEPRCH) [MIM:246200]
119_ILE MET ClinVar
chr19:7267570
rs121913159
Pathogenic - 0.2029 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
121_LYS TER ClinVar
chr19:7267566
rs121913155
Pathogenic - - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
133_TRP TER ClinVar
chr19:7267529
rs121913146
Pathogenic - - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MONDO:MONDO:0012520,MedGen:C0342278,OMIM:610549,Orphanet:2297]
140_VAL LEU VAR_015910
rs938519025
LP/P - 0.3868 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
152_ASN ASP 8.3kJPN
chr19:7267473
-
- 0.0001 0.089 -
171_ALA THR 8.3kJPN
chr19:7267416
-
- 0.0001 0.103 -
176_GLY ARG gnomAD
chr19:7267401
rs545565240
- 0.000178959 0.3363 -
184_THR ILE ClinVar
chr19:7267376
rs1967766760
Pathogenic - 0.933 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
193_PRO LEU VAR_004083
rs749094324
LB/B - 0.4885 -
201_CYS ARG VAR_041429
-
US - 0.9973 A gastric adenocarcinoma sample
209_HIS ARG VAR_004084
rs121913145
LP/P - 0.9365 Leprechaunism (LEPRCH) [MIM:246200]
209_HIS ARG ClinVar
chr19:7184594
rs121913145
Pathogenic - 0.9365 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
211_GLU LYS ClinVar
chr19:7184589
-
Likely pathogenic - 0.6601 not provided [MedGen:C3661900]
213_LEU PRO 8.3kJPN
chr19:7184582
-
- 0.0001 0.9972 -
224_LYS ASN 8.3kJPN
chr19:7184548
-
- 0.0001 0.3929 -
229_ARG CYS VAR_079536
rs781007453
LP/P - 0.8155 Rabson-Mendenhall syndrome (RMS) [MIM:262190]
229_ARG CYS 8.3kJPN
chr19:7184535
rs781007453
- 0.0001 0.8155 -
233_LEU PRO VAR_004085
rs121913141
LP/P - 0.9492 Leprechaunism (LEPRCH) [MIM:246200]
233_LEU PRO ClinVar
chr19:7184522
rs121913141
Pathogenic - 0.9492 Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
242_PRO LEU 8.3kJPN
chr19:7184495
rs1448475843
- 0.0001 0.292 -
244_PRO LEU 8.3kJPN
chr19:7184489
rs200199169
- 0.0001 0.1475 -
244_PRO SER 8.3kJPN
chr19:7184490
rs537134904
- 0.0001 0.0893 -
252_ARG CYS VAR_015540
rs1568470274
LP/P - 0.9676 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
252_ARG HIS VAR_031519
rs1329693158
LP/P - 0.4125 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
253_CYS TYR VAR_015911
-
LP/P - 0.9987 Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
259_CYS TYR VAR_079537
-
LP/P - 0.999 Leprechaunism (LEPRCH) [MIM:246200]
259_CYS SER 8.3kJPN
chr19:7184444
-
- 0.0001 0.9997 -
293_THR MET gnomAD
chr19:7184342
rs138528064
- 0.000203087 0.0877 -
299_LEU PHE 8.3kJPN
chr19:7174739
-
- 0.0001 0.4786 -
307_PRO LEU 8.3kJPN
chr19:7174716
rs373995681
- 0.0001 0.0838 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.