PDB ID 3W11     CHAIN E
Protein name Insulin receptor domains L1-CR
Uniprot Accession P06213
The number of similar proteins 10
The number of binding states 4
The number of binding partners 3

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3W11 (CHAIN: E)
1 6VEP   6VEP   P01308  
2 Monomeric state
3 P05019  
4 5J3H   5J3H  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   HLYPGEVCPG   MDIRNNLTRL   HELENCSVIE   GHLQILLMFK   TRPEDFRDLS   50
51   FPKLIMITDY   LLLFRVYGLE   SLKDLFPNLT   VIRGSRLFFN   YALVIFEMVH   100
101   LKELGLYNLM   NITRGSVRIE   KNNELCYLAT   IDWSRILDSV   EDNHIVLNKD   150
151   DNEECGDICP   GTAKGKTNCP   ATVINGQFVE   RCWTHSHCQK   VCPTICKSHG   200
201   CTAEGLCCHS   ECLGNCSQPD   DPTKCVACRN   FYLDGRCVET   CPPPYYHFQD   250
251   WRCVNFSFCQ   DLHHKCKNSR   RQGCHQYVIH   NNKCIPECPS   GYTMNSSNLL   300
301   CTPCLGPCPK           350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
15_ASN LYS VAR_004079 rs121913143
LP/P - Rabson-Mendenhall syndrome (RMS) [MIM:262190]
15_ASN LYS ClinVar
chr19:7267882 		rs121913143
Pathogenic - Rabson-Mendenhall syndrome [MONDO:MONDO:0009874,MedGen:C0271695,OMIM:262190,Orphanet:769]
24_GLU LYS gnomAD
chr19:7267857 		rs140852238
- 0.000453677 -
28_VAL ALA VAR_004080 rs121913152
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
28_VAL ALA ClinVar
chr19:7267844 		rs121913152
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
29_ILE THR VAR_079535 rs1555689937
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
31_GLY ARG VAR_004081 rs52836744
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
31_GLY ARG ClinVar
chr19:7267836 		rs52836744
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
59_ASP GLY VAR_015907 -
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
62_LEU PRO VAR_015908 -
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
65_ARG TRP 8.3kJPN
chr19:7267734 		-
- 0.0001 -
86_ARG PRO VAR_004082 rs121913153
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
86_ARG PRO ClinVar
chr19:7267670 		rs121913153
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
92_ALA VAL VAR_015909 rs1347473020
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
93_LEU GLN VAR_031518 -
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
105_GLY SER ClinVar
chr19:7267614 		rs886037750
Pathogenic - Rabson-Mendenhall syndrome [MONDO:MONDO:0009874,MedGen:C0271695,OMIM:262190,Orphanet:769]
118_ARG SER 8.3kJPN
chr19:7267575 		-
- 0.0002 -
119_ILE MET VAR_015539 rs121913159
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
119_ILE MET ClinVar
chr19:7267570 		rs121913159
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
121_LYS TER ClinVar
chr19:7267566 		rs121913155
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
133_TRP TER ClinVar
chr19:7267529 		rs121913146
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MONDO:MONDO:0012520,MedGen:C0342278,OMIM:610549,Orphanet:2297]
140_VAL LEU VAR_015910 rs938519025
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
152_ASN ASP 8.3kJPN
chr19:7267473 		-
- 0.0001 -
171_ALA THR 8.3kJPN
chr19:7267416 		-
- 0.0001 -
176_GLY ARG gnomAD
chr19:7267401 		rs545565240
- 0.000178959 -
184_THR ILE ClinVar
chr19:7267376 		rs1967766760
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
193_PRO LEU VAR_004083 rs749094324
LB/B - -
201_CYS ARG VAR_041429 -
US - A gastric adenocarcinoma sample
209_HIS ARG VAR_004084 rs121913145
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
209_HIS ARG ClinVar
chr19:7184594 		rs121913145
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
211_GLU LYS ClinVar
chr19:7184589 		-
Likely pathogenic - not provided [MedGen:C3661900]
213_LEU PRO 8.3kJPN
chr19:7184582 		-
- 0.0001 -
224_LYS ASN 8.3kJPN
chr19:7184548 		-
- 0.0001 -
229_ARG CYS VAR_079536 rs781007453
LP/P - Rabson-Mendenhall syndrome (RMS) [MIM:262190]
229_ARG CYS 8.3kJPN
chr19:7184535 		rs781007453
- 0.0001 -
233_LEU PRO VAR_004085 rs121913141
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
233_LEU PRO ClinVar
chr19:7184522 		rs121913141
Pathogenic - Leprechaunism syndrome [MONDO:MONDO:0009517,MedGen:C0265344,OMIM:246200,Orphanet:508]
242_PRO LEU 8.3kJPN
chr19:7184495 		rs1448475843
- 0.0001 -
244_PRO LEU 8.3kJPN
chr19:7184489 		rs200199169
- 0.0001 -
244_PRO SER 8.3kJPN
chr19:7184490 		rs537134904
- 0.0001 -
252_ARG CYS VAR_015540 rs1568470274
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
252_ARG HIS VAR_031519 rs1329693158
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
253_CYS TYR VAR_015911 -
LP/P - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
259_CYS TYR VAR_079537 -
LP/P - Leprechaunism (LEPRCH) [MIM:246200]
259_CYS SER 8.3kJPN
chr19:7184444 		-
- 0.0001 -
293_THR MET gnomAD
chr19:7184342 		rs138528064
- 0.000203087 -
299_LEU PHE 8.3kJPN
chr19:7174739 		-
- 0.0001 -
307_PRO LEU 8.3kJPN
chr19:7174716 		rs373995681
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.