PDB ID 3VTV     CHAIN A
Protein name Optineurin, microtubule-associated proteins 1A/1B light chain 3B
Uniprot Accession Q96CV9
The number of similar proteins 36
The number of binding states 7
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3VTV (CHAIN: A)
1 Monomeric state
2 Q9GZQ8  
3 Q5ZUV9  
4 Q9Y4P1  
5 Q9GZQ8   Q9GZQ8  
6 Q0PF16   Q0PF16  
7 Q9GZQ8   Q9GZQ8   Q9GZQ8  

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Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   GSEEGEEEDE   FVEIGGPSEK   TFKQRRTFEQ   RVEDVRLIRE   QHPTKIPVII   50
51   ERYKGEKQLP   VLDKTKFLVP   DHVNMSELIK   IIRRRLQLNA   NQAFFLLVNG   100
101   HSMVSVSTPI   SEVYESEKDE   DGFLYMVYAS   QETF     150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
18_SER LEU gnomAD
chr16:87426041
rs536459957
- 0.00125792 -
18_SER TRP 8.3kJPN
chr16:87426041
rs536459957
- 0.0008 -
29_GLU LYS gnomAD
chr12:117013787
rs192133007
- 0.000135191 -
35_VAL ILE 8.3kJPN
chr16:87432438
-
- 0.0001 -
37_LEU PHE 8.3kJPN
chr12:117013811
-
- 0.0001 -
40_GLU GLN gnomAD
chr16:87432453
rs113610787
- 0.0060481 -
42_HIS TYR 8.3kJPN
chr20:33147050
-
- 0.0001 -
47_PRO SER 8.3kJPN
chr12:117013841
-
- 0.0001 -
49_ILE MET 8.3kJPN
chr16:87435786
rs1158904097
- 0.0001 -
53_TYR HIS 8.3kJPN
chr12:117013859
rs200048902
- 0.0078 -
55_GLY SER 8.3kJPN
chr16:87435802
rs200880487
- 0.0001 -
58_GLN HIS 8.3kJPN
chr12:117013876
-
- 0.0001 -
61_VAL LEU 8.3kJPN
chr20:33147190
-
- 0.0001 -
65_THR SER gnomAD
chr20:33147203
rs755865335
- 0.000283569 -
75_MET LEU 8.3kJPN
chr12:117013925
-
- 0.0001 -
80_LYS GLU 8.3kJPN
chr16:87435877
rs760756783
- 0.0001 -
82_ILE SER 8.3kJPN
chr20:33147254
-
- 0.0001 -
83_ARG THR gnomAD
chr12:117013950
rs775368545
- 0.000111334 -
84_ARG LYS gnomAD
chr12:117013953
rs144234011
- 0.00322073 -
84_ARG GLY 8.3kJPN
chr20:33147541
-
- 0.0001 -
85_ARG CYS 8.3kJPN
chr12:117013955
-
- 0.0001 -
91_ASN HIS 8.3kJPN
chr16:87436551
rs1420825485
- 0.0004 -
100_GLY GLU 8.3kJPN
chr16:87436579
-
- 0.0001 -
106_VAL PHE 8.3kJPN
chr16:87436596
-
- 0.0001 -
122_GLY SER 8.3kJPN
chr20:33147655
rs1347928984
- 0.0001 -
127_VAL ILE 8.3kJPN
chr12:117014081
-
- 0.0001 -
128_CYS TYR gnomAD
chr12:117014085
rs111327250
- 0.0059828 -
128_TYR CYS gnomAD
chr16:87436663
rs200708875
- 0.00128707 -
132_GLU VAL gnomAD
chr12:117014097
rs142080200
- 0.00322113 -
133_THR ALA gnomAD
chr12:117014099
rs113585095
- 0.00611404 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.