PDB ID 3VTV     CHAIN A
Protein name Optineurin, microtubule-associated proteins 1A/1B light chain 3B
Uniprot Accession Q96CV9
The number of similar proteins 36
The number of binding states 7
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3VTV (CHAIN: A)
1 Monomeric state
2 Q9GZQ8  
3 Q5ZUV9  
4 Q9Y4P1  
5 Q9GZQ8   Q9GZQ8  
6 Q0PF16   Q0PF16  
7 Q9GZQ8   Q9GZQ8   Q9GZQ8  

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Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   GSEEGEEEDE   FVEIGGPSEK   TFKQRRTFEQ   RVEDVRLIRE   QHPTKIPVII   50
51   ERYKGEKQLP   VLDKTKFLVP   DHVNMSELIK   IIRRRLQLNA   NQAFFLLVNG   100
101   HSMVSVSTPI   SEVYESEKDE   DGFLYMVYAS   QETF     150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
18_SER TRP 4.7kJPN
chr16:87426041
rs536459957
- 0.0008 -
47_PRO SER 4.7kJPN
chr12:117013841
-
- 0.0001 -
49_ILE MET 4.7kJPN
chr16:87435786
rs1158904097
- 0.0001 -
53_TYR HIS 4.7kJPN
chr12:117013859
rs200048902
- 0.0081 -
55_GLY SER 4.7kJPN
chr16:87435802
rs200880487
- 0.0001 -
58_GLN HIS 4.7kJPN
chr12:117013876
-
- 0.0001 -
61_VAL LEU 4.7kJPN
chr20:33147190
-
- 0.0001 -
80_LYS GLU 4.7kJPN
chr16:87435877
rs760756783
- 0.0001 -
85_ARG CYS 4.7kJPN
chr12:117013955
-
- 0.0001 -
91_ASN HIS 4.7kJPN
chr16:87436551
rs1420825485
- 0.0001 -
100_GLY GLU 4.7kJPN
chr16:87436579
-
- 0.0001 -
103_MET LEU 4.7kJPN
chr20:33147598
-
- 0.0001 -
105_SER CYS 4.7kJPN
chr20:33147604
-
- 0.0001 -
105_SER THR 4.7kJPN
chr20:33147605
-
- 0.0001 -
106_VAL PHE 4.7kJPN
chr16:87436596
-
- 0.0001 -
108_THR ALA 4.7kJPN
chr20:33147613
-
- 0.0001 -
109_PRO ALA 4.7kJPN
chr20:33147616
rs1488302498
- 0.0001 -
111_ALA SER 4.7kJPN
chr20:33147622
rs760673110
- 0.0001 -
112_ASP GLU 4.7kJPN
chr20:33147627
-
- 0.0001 -
113_ILE LEU 4.7kJPN
chr20:33147628
-
- 0.0001 -
113_ILE MET 4.7kJPN
chr20:33147630
-
- 0.0001 -
116_GLN ARG 4.7kJPN
chr20:33147638
rs1452406837
- 0.0001 -
118_LYS GLN 4.7kJPN
chr20:33147643
-
- 0.0001 -
118_LYS ARG 4.7kJPN
chr20:33147644
-
- 0.0001 -
120_GLU GLN 4.7kJPN
chr20:33147649
-
- 0.0001 -
127_VAL ILE 4.7kJPN
chr12:117014081
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.