PDB ID 3SPA     CHAIN A
Protein name DNA-directed RNA polymerase, mitochondrial
Uniprot Accession O00411
The number of similar proteins 5
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3SPA (CHAIN: A)
1 Monomeric state
2 Q96QE5  
3 O00411  
4 Q9H5Q4   Q00059  

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Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MGHHHHHHRK   VQMGAKDATP   VPCGRWAKIL   EKDKRTQQMR   MQRLKAKLQM   50
51   PFQSGEFKAL   TRRLQVEPRL   LSKQMAGCLE   DCTRQAPESP   WEEQLARLLQ   100
101   EAPGKLSLDV   EQAPSGQHSQ   AQLSGQQQRL   LAFFKCCLLT   DQLPLAHHLL   150
151   VVHHGQRQKR   KLLTLDMYNA   VMLGWARQGA   FKELVYVLFM   VKDAGLTPDL   200
201   LSYAAALQCM   GRQDQDAGTI   ERCLEQMSQE   GLKLQALFTA   VLLSEEDRAT   250
251   VLKAVHKVKP   TFSLPPQLPP   PVNTSKLLRD   VYAKDGRVSY   PKLHLPLKTL   300
301   QCLFEKQLHM   ELASRVCVVS   VEKPTLPSKE   VKHARKTLKT   LRDQWEKALC   350
351   RALRETKNRL   EREVYEGRFS   LYPFLCLLDE   REVVRMLLQV   LQALPAQGES   400
401   FTTLARELSA   RTFSRHVVQR   QRVSGQVQAL   QNHYRKYLCL   LASDAEVPEP   450
451   CLPRQYWEAL   GAPEALREQP   WPLPVQMELG   KLLAEMLVQA   TQMPCSLDKP   500
501   HRSSRLVPVL   YHVYSFRNVQ   QIGILKPHPA   YVQLLEKAAE   PTLTFEAVDV   550
551   PMLCPPLPWT   SPHSGAFLLS   PTKLMRTVEG   ATQHQELLET   CPPTALHGAL   600
601   DALTQLGNCA   WRVNGRVLDL   VLQLFQAKGC   PQLGVPAPPS   EAPQPPEAHL   650
651   PHSAAPARKA   ELRRELAHCQ   KVAREMHSLR   AEALYRLSLA   QHLRDRVFWL   700
701   PHNMDFRGRT   YPCPPHFNHL   GSDVARALLE   FAQGRPLGPH   GLDWLKIHLV   750
751   NLTGLKKREP   LRKRLAFAEE   VMDDILDSAD   QPLTGRKWWM   GAEEPWQTLA   800
801   CCMEVANAVR   ASDPAAYVSH   LPVHQDGSCN   GLQHYAALGR   DSVGAASVNL   850
851   EPSDVPQDVY   SGVAAQVEVF   RRQDAQRGMR   VAQVLEGFIT   RKVVKQTVMT   900
901   VVYGVTRYGG   RLQIEKRLRE   LSDFPQEFVW   EASHYLVRQV   FKSLQEMFSG   950
951   TRAIQHWLTE   SARLISHMGS   VVEWVTPLGV   PVIQPYRLDS   KVKQIGGGIQ   1000
1001   SITYTHNGDI   SRKPNTRKQK   NGFPPNFIHS   LDSSHMMLTA   LHCYRKGLTF   1050
1051   VSVHDCYWTH   AADVSVMNQV   CREQFVRLHS   EPILQDLSRF   LVKRFCSEPQ   1100
1101   KILEASQLKE   TLQAVPKPGA   FDLEQVKRST   YFFS     1150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
229_PHE SER 4.7kJPN
chr19:629676
-
- 0.0002 -
229_PHE VAL 4.7kJPN
chr19:629677
-
- 0.0002 -
318_ARG SER 4.7kJPN
chr19:624905
-
- 0.0007 -
337_VAL ILE 4.7kJPN
chr19:624850
rs201346718
- 0.0001 -
346_THR ALA 4.7kJPN
chr19:624823
rs777572472
- 0.0001 -
357_THR PRO 4.7kJPN
chr19:624790
rs770914181
- 0.0003 -
362_PRO SER 4.7kJPN
chr19:624775
-
- 0.0001 -
366_PRO SER 4.7kJPN
chr19:624763
rs201473800
- 0.0015 -
367_PRO LEU 4.7kJPN
chr19:624759
rs374260495
- 0.0001 -
367_PRO ALA 4.7kJPN
chr19:624760
rs146221322
- 0.0026 -
369_ASN SER 4.7kJPN
chr19:624753
rs749862454
- 0.0004 -
438_ARG GLN 4.7kJPN
chr19:622963
-
- 0.0002 -
441_TRP SER 4.7kJPN
chr19:622954
-
- 0.0001 -
447_ARG GLN 4.7kJPN
chr19:622936
rs144179084
- 0.0007 -
464_ARG TRP 4.7kJPN
chr19:622886
rs775678643
- 0.0002 -
483_LEU PHE 4.7kJPN
chr19:622829
rs760945130
- 0.0001 -
500_LEU PRO 4.7kJPN
chr19:622709
-
- 0.0001 -
511_ARG GLN 4.7kJPN
chr19:622676
rs1245111840
- 0.0001 -
526_LEU VAL 4.7kJPN
chr19:622632
-
- 0.0002 -
534_LEU PHE 4.7kJPN
chr19:622608
rs764456049
- 0.0002 -
541_ALA SER 4.7kJPN
chr19:622587
rs56226067
- 0.0111 -
555_GLU ALA 4.7kJPN
chr19:622336
rs2238549
- 0.5491 -
558_ALA THR 4.7kJPN
chr19:622328
rs755299102
- 0.0002 -
616_GLN TER 4.7kJPN
chr19:622154
rs768967483
- 0.0001 -
621_LEU GLN 4.7kJPN
chr19:621836
-
- 0.0001 -
622_LYS GLN 4.7kJPN
chr19:621834
-
- 0.0001 -
626_ALA THR 4.7kJPN
chr19:621822
rs747554799
- 0.0005 -
678_THR MET 4.7kJPN
chr19:621665
rs1430315671
- 0.0001 -
681_GLN TER 4.7kJPN
chr19:621657
rs776192083
- 0.0002 -
683_LEU VAL 4.7kJPN
chr19:621651
rs770415736
- 0.0003 -
688_PRO SER 4.7kJPN
chr19:621636
-
- 0.0003 -
691_ALA VAL 4.7kJPN
chr19:621626
-
- 0.0001 -
713_VAL LEU 4.7kJPN
chr19:621561
rs10421235
- 0.0876 -
717_VAL MET 4.7kJPN
chr19:621549
rs1380944961
- 0.0004 -
723_ALA VAL 4.7kJPN
chr19:621530
rs1363815639
- 0.0166 -
734_PRO LEU 4.7kJPN
chr19:621497
rs1267559063
- 0.0001 -
789_LEU MET 4.7kJPN
chr19:621333
-
- 0.0001 -
792_ARG SER 4.7kJPN
chr19:621324
rs759201735
- 0.0001 -
807_TYR SER 4.7kJPN
chr19:621278
-
- 0.0026 -
808_PRO SER 4.7kJPN
chr19:621276
rs778477461
- 0.0004 -
821_ALA THR 4.7kJPN
chr19:621237
-
- 0.0001 -
822_ARG GLY 4.7kJPN
chr19:621234
-
- 0.0001 -
826_GLU VAL 4.7kJPN
chr19:621221
-
- 0.0001 -
829_GLN GLU 4.7kJPN
chr19:621213
-
- 0.0001 -
831_ARG SER 4.7kJPN
chr19:621207
-
- 0.0001 -
840_TRP TER 4.7kJPN
chr19:621179
-
- 0.0001 -
843_ILE VAL 4.7kJPN
chr19:621171
rs751459962
- 0.0003 -
859_LYS MET 4.7kJPN
chr19:621122
-
- 0.0001 -
864_ALA VAL 4.7kJPN
chr19:621107
rs775039991
- 0.0001 -
875_ALA VAL 4.7kJPN
chr19:621074
rs767856533
- 0.0002 -
884_TRP SER 4.7kJPN
chr19:620477
-
- 0.0001 -
900_GLU LYS 4.7kJPN
chr19:620430
rs796052172
- 0.0001 -
941_ALA THR 4.7kJPN
chr19:620023
-
- 0.0001 -
963_VAL MET 4.7kJPN
chr19:619765
-
- 0.0001 -
994_VAL GLY 4.7kJPN
chr19:619671
-
- 0.0003 -
1014_LEU PHE 4.7kJPN
chr19:619612
-
- 0.0001 -
1015_ARG TRP 4.7kJPN
chr19:619609
rs751370183
- 0.0003 -
1034_ARG CYS 4.7kJPN
chr19:619263
-
- 0.0075 -
1041_GLN LYS 4.7kJPN
chr19:619242
-
- 0.001 -
1059_ARG CYS 4.7kJPN
chr19:619089
rs757765767
- 0.0001 -
1076_VAL ILE 4.7kJPN
chr19:619038
rs746274300
- 0.0001 -
1078_VAL ILE 4.7kJPN
chr19:619032
rs370808958
- 0.0001 -
1113_ARG GLY 4.7kJPN
chr19:618573
rs751211087
- 0.0001 -
1117_ASN SER 4.7kJPN
chr19:618560
-
- 0.0001 -
1159_ASP ALA 4.7kJPN
chr19:617796
-
- 0.0001 -
1220_GLU GLY 4.7kJPN
chr19:617308
rs905785861
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.