PDB ID 3KWQ     CHAIN C
Protein name Histone H2A
Uniprot Accession Q6AZJ8
The number of similar proteins 292
The number of binding states 16
The number of binding partners 8

Molecule viewer

#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   AKTRSSRAGL   QFPVGRVHRL   LRKGNYAERV   GAGAPVYLAA   VLEYLTAEIL   50
51   ELAGNAARDN   KKTRIIPRHL   QLAVRNDEEL   NKLLGRVTIA   QGGVLPNIQS   100
101   VLLPKKT           150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
14_ALA VAL 4.7kJPN
chr1:228645475
rs942855
- 0.0001 -
14_ALA VAL 4.7kJPN
chr6:26199428
rs773531178
- 0.0001 -
14_ALA THR 4.7kJPN
chr6:27100893
rs200399044
- 0.0005 -
14_ALA THR 4.7kJPN
chr6:27806075
rs1006888623
- 0.0014 -
15_LYS ARG 4.7kJPN
chr1:149859420
rs1553760178
- 0.0002 -
15_LYS ARG 4.7kJPN
chr6:27806071
-
- 0.0004 -
16_THR PRO 4.7kJPN
chr6:26217251
-
- 0.0001 -
18_SER TER 4.7kJPN
chr1:228645463
rs754510222
- 0.0001 -
19_SER ALA 4.7kJPN
chr6:25726698
rs761780090
- 0.0001 -
19_SER PRO 4.7kJPN
chr6:27100908
-
- 0.0001 -
19_SER PHE 4.7kJPN
chr6:27833191
rs184589037
- 0.0014 -
20_ARG TRP 4.7kJPN
chr6:26199411
rs763562699
- 0.0001 -
24_GLN TER 4.7kJPN
chr6:26199399
rs140533379
- 0.0001 -
25_PHE LEU 4.7kJPN
chr6:26217278
-
- 0.0002 -
25_PHE LEU 4.7kJPN
chr6:27114985
-
- 0.0001 -
26_PRO SER 4.7kJPN
chr6:26033718
rs767532920
- 0.0001 -
32_ARG TER 4.7kJPN
chr6:27806021
-
- 0.0001 -
35_ARG HIS 4.7kJPN
chr6:25726649
rs371440858
- 0.0001 -
35_ARG PRO 4.7kJPN
chr6:27833239
-
- 0.0003 -
36_LYS MET 4.7kJPN
chr6:27833242
-
- 0.0002 -
37_GLY SER 4.7kJPN
chr1:149858636
rs782788423
- 0.0001 -
37_GLY ARG 4.7kJPN
chr6:25726644
rs189327307
- 0.0002 -
37_GLY SER 4.7kJPN
chr6:27860816
rs201009000
- 0.0001 -
38_ASN SER 4.7kJPN
chr6:27115023
rs988081913
- 0.0001 -
40_ALA SER 4.7kJPN
chr1:149859346
-
- 0.0001 -
41_GLU LYS 4.7kJPN
chr6:27100974
-
- 0.0001 -
43_VAL LEU 4.7kJPN
chr6:27860798
rs549660103
- 0.0002 -
47_ALA VAL 4.7kJPN
chr6:27782376
rs200522974
- 0.0001 -
47_ALA SER 4.7kJPN
chr6:27782377
rs1250781403
- 0.0001 -
47_ALA GLU 4.7kJPN
chr6:27805975
rs149494377
- 0.06 -
48_PRO LEU 4.7kJPN
chr6:25726610
rs1417126640
- 0.0001 -
48_PRO SER 4.7kJPN
chr6:27776132
-
- 0.0001 -
49_VAL LEU 4.7kJPN
chr1:149859319
rs782428337
- 0.0001 -
50_TYR CYS 4.7kJPN
chr6:26199320
rs776773287
- 0.0001 -
50_TYR PHE 4.7kJPN
chr6:27115059
-
- 0.0001 -
50_TYR CYS 4.7kJPN
chr6:27805966
rs544484889
- 0.0001 -
52_ALA GLY 4.7kJPN
chr6:25726598
rs375336327
- 0.0001 -
53_ALA VAL 4.7kJPN
chr1:228645358
rs564487637
- 0.0001 -
53_ALA GLY 4.7kJPN
chr6:26199311
-
- 0.0013 -
53_ALA GLY 4.7kJPN
chr6:27782358
-
- 0.0001 -
55_LEU PHE 4.7kJPN
chr6:26199304
-
- 0.0001 -
55_LEU VAL 4.7kJPN
chr6:26199306
rs755825653
- 0.0029 -
57_TYR SER 4.7kJPN
chr6:26033624
-
- 0.0008 -
57_TYR SER 4.7kJPN
chr6:26124633
-
- 0.0003 -
59_THR ILE 4.7kJPN
chr6:26033618
rs545768553
- 0.0001 -
59_THR ALA 4.7kJPN
chr6:27805940
-
- 0.0003 -
61_GLU ASP 4.7kJPN
chr6:27833318
-
- 0.0001 -
62_ILE VAL 4.7kJPN
chr1:149859280
-
- 0.0001 -
71_ARG HIS 4.7kJPN
chr6:25726541
rs771578160
- 0.0001 -
73_ASN LYS 4.7kJPN
chr6:27805896
rs371861857
- 0.0026 -
80_PRO SER 4.7kJPN
chr1:228645278
-
- 0.0003 -
80_PRO THR 4.7kJPN
chr12:14927645
-
- 0.0001 -
84_GLN TER 4.7kJPN
chr6:26199219
rs770480882
- 0.0001 -
84_GLN TER 4.7kJPN
chr6:27115160
rs143700242
- 0.0001 -
86_ALA SER 4.7kJPN
chr1:149858783
-
- 0.0001 -
87_ILE VAL 4.7kJPN
chr6:27115169
rs767886879
- 0.0001 -
87_ILE VAL 4.7kJPN
chr6:27805856
rs551039045
- 0.0001 -
87_ILE VAL 4.7kJPN
chr6:27833394
-
- 0.0001 -
88_ARG HIS 4.7kJPN
chr6:27805852
-
- 0.0001 -
96_LEU PHE 4.7kJPN
chr6:25726467
rs1219098411
- 0.0001 -
97_LEU PRO 4.7kJPN
chr6:27860635
-
- 0.0001 -
100_VAL ALA 4.7kJPN
chr6:25726454
-
- 0.0001 -
100_VAL ILE 4.7kJPN
chr6:27782218
rs1431545616
- 0.0002 -
112_GLN GLU 4.7kJPN
chr6:27805781
-
- 0.0004 -
113_ALA VAL 4.7kJPN
chr12:14927745
-
- 0.0001 -
114_VAL MET 4.7kJPN
chr6:27115250
rs768852602
- 0.0008 -
920_THR ALA 4.7kJPN
chr6:26124821
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.