PDB ID 3KWQ     CHAIN B
Protein name Histone H4
Uniprot Accession P62799
The number of similar proteins 228
The number of binding states 22
The number of binding partners 19

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   KVLRDNIQGI   TKPAIRRLAR   RGGVKRISGL   IYEETRGVLK   VFLENVIRDA   50
51   VTYTEHAKRK   TVTAMDVVYA   LKRQGRTLYG   FGG     100

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
26_ILE SER gnomAD
chr6:26189225
rs750884941
- 0.000111404 -
31_LYS GLN 8.3kJPN
chr6:26027387
-
- 0.0001 -
33_ALA VAL 8.3kJPN
chr6:26022007
rs776166186
- 0.0001 -
33_ALA THR 8.3kJPN
chr6:26027381
-
- 0.0001 -
34_ILE LEU 8.3kJPN
chr6:26189202
rs1011647555
- 0.0001 -
34_ILE THR 8.3kJPN
chr6:26204976
rs768482468
- 0.0001 -
37_LEU PHE 8.3kJPN
chr6:27107199
-
- 0.0001 -
45_ARG TER 8.3kJPN
chr6:26027345
rs767025164
- 0.0001 -
47_SER TER 8.3kJPN
chr6:26240796
-
- 0.0001 -
50_ILE VAL gnomAD
chr6:26247055
rs370289402
- 0.000115357 -
50_ILE LEU 8.3kJPN
chr6:26205023
rs756223901
- 0.0001 -
50_ILE VAL 8.3kJPN
chr6:26240804
rs1367180593
- 0.0001 -
51_TYR PHE 8.3kJPN
chr6:27799151
-
- 0.0001 -
52_GLU ALA 8.3kJPN
chr6:26027323
-
- 0.0001 -
52_GLU GLY 8.3kJPN
chr6:26240811
rs773141004
- 0.0001 -
54_THR ILE gnomAD
chr6:26247042
rs573072581
- 0.000167058 -
54_THR SER 8.3kJPN
chr6:26240817
rs1046492095
- 0.0001 -
55_ARG HIS 8.3kJPN
chr6:26027314
rs1195708639
- 0.0002 -
55_ARG GLN 8.3kJPN
chr12:14923852
rs534031465
- 0.0001 -
55_ARG TRP 8.3kJPN
chr12:14923853
rs762150713
- 0.0001 -
57_VAL GLY 8.3kJPN
chr6:26027308
rs1031808362
- 0.0001 -
57_VAL LEU 8.3kJPN
chr6:26189133
-
- 0.0001 -
57_VAL ILE 8.3kJPN
chr6:26205044
-
- 0.0001 -
57_VAL LEU 8.3kJPN
chr6:26247034
rs200377159
- 0.0082 -
57_VAL MET 8.3kJPN
chr6:27107259
rs1013949364
- 0.0001 -
60_VAL ALA 8.3kJPN
chr6:26027299
rs780045847
- 0.0001 -
61_PHE LEU 8.3kJPN
chr6:27799120
rs746877857
- 0.0002 -
64_ASN ASP 8.3kJPN
chr6:26240846
-
- 0.0001 -
65_VAL ILE 8.3kJPN
chr6:26104371
-
- 0.0001 -
66_ILE VAL gnomAD
chr6:26027282
rs777598662
- 0.000131219 -
67_ARG TRP 8.3kJPN
chr6:27107289
rs1291040170
- 0.0005 -
67_ARG HIS 8.3kJPN
chr12:14923816
-
- 0.0001 -
68_ASP GLY 8.3kJPN
chr6:26027275
-
- 0.0001 -
70_VAL MET 8.3kJPN
chr6:26246995
rs140916075
- 0.0001 -
73_THR PRO 8.3kJPN
chr12:14923799
rs1171400276
- 0.0002 -
74_GLU ASP 8.3kJPN
chr6:27107312
-
- 0.0001 -
77_LYS ASN 8.3kJPN
chr6:26240887
-
- 0.0001 -
78_ARG PRO gnomAD
chr6:26022142
rs143300286
- 0.000374421 -
78_ARG CYS gnomAD
chr6:26027246
rs777473620
- 0.000151114 -
78_ARG PRO gnomAD
chr6:26240889
rs747684677
- 0.000132062 -
80_THR ALA 8.3kJPN
chr12:14923778
rs760388462
- 0.0001 -
81_VAL ALA gnomAD
chr6:26022151
rs199857326
- 0.000227104 -
82_THR ILE gnomAD
chr6:26022154
rs776076104
- 0.000299053 -
82_THR ILE 8.3kJPN
chr6:26027233
rs150504596
- 0.0001 -
82_THR ILE 8.3kJPN
chr6:26189057
rs144742137
- 0.005 -
82_THR SER 8.3kJPN
chr6:26246958
-
- 0.0001 -
82_THR ILE 8.3kJPN
chr6:27799058
rs372460457
- 0.0001 -
83_ALA VAL gnomAD
chr6:26022157
rs147105535
- 0.00173549 -
83_ALA SER 8.3kJPN
chr6:26240903
-
- 0.0001 -
84_MET ILE 8.3kJPN
chr6:26027226
-
- 0.0001 -
84_MET ILE 8.3kJPN
chr6:27792157
-
- - -
85_ASP GLY gnomAD
chr6:27841032
rs201833445
- 0.000127245 -
85_ASP GLU 8.3kJPN
chr6:26022164
-
- 0.0001 -
85_ASP ASN 8.3kJPN
chr6:26240909
-
- 0.0004 -
86_VAL LEU 8.3kJPN
chr6:26027222
-
- 0.0001 -
87_VAL ILE 8.3kJPN
chr6:26104437
-
- 0.0001 -
88_TYR HIS 8.3kJPN
chr12:14923754
-
- 0.0001 -
89_ALA SER gnomAD
chr6:26104443
rs144469714
- 0.000318441 -
89_ALA THR 8.3kJPN
chr6:26104443
rs144469714
- 0.0001 -
89_ALA VAL 8.3kJPN
chr6:26104444
-
- 0.0001 -
89_ALA THR 8.3kJPN
chr12:14923751
rs776707867
- 0.0001 -
90_LEU PRO 8.3kJPN
chr6:26205144
-
- 0.0001 -
92_ARG CYS 8.3kJPN
chr6:26104452
-
- 0.0001 -
95_ARG GLY 8.3kJPN
chr6:27792188
-
- 0.0001 -
99_GLY VAL 8.3kJPN
chr6:26027182
-
- 0.0001 -
99_GLY ASP 8.3kJPN
chr6:27840990
-
- 0.0001 -
102_GLY SER gnomAD
chr6:27840982
rs45526033
- 0.00601938 -
102_GLY ASP 8.3kJPN
chr6:26240961
rs151068394
- 0.0075 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.