PDB ID 3I6L     CHAIN D
Protein name HLA class I histocompatibility antigen, A-24 alpha chain
Uniprot Accession P05534
The number of similar proteins 320
The number of binding states 20
The number of binding partners 10

Molecule viewer

#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GSHSMRYFST   SVSRPGRGEP   RFIAVGYVDD   TQFVRFDSDA   ASQRMEPRAP   50
51   WIEQEGPEYW   DEETGKVKAH   SQTDRENLRI   ALRYYNQSEA   GSHTLQMMFG   100
101   CDVGSDGRFL   RGYHQYAYDG   KDYIALKEDL   RSWTAADMAA   QITKRKWEAA   150
151   HVAEQQRAYL   EGTCVDGLRR   YLENGKETLQ   RTDPPKTHMT   HHPISDHEAT   200
201   LRCWALGFYP   AEITLTWQRD   GEDQTQDTEL   VETRPAGDGT   FQKWAAVVVP   250
251   SGEEQRYTCH   VQHEGLPKPL   TLRW       300

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
3_HIS GLN VAR_004355 rs41541319
Polymorphism - -
3_HIS GLN 4.7kJPN
chr6:29910541
rs41541319
- 0.0079 -
6_ARG LYS 4.7kJPN
chr6:31239630
rs1131151
- 0.164 -
7_TYR ASP 4.7kJPN
chr6:29691452
-
- 0.0017 -
9_PHE ILE 4.7kJPN
chr6:29910557
rs1136659
- 0.144 -
9_ASP TYR 4.7kJPN
chr6:31239622
rs9264668
- 0.8512 -
9_TYR HIS 4.7kJPN
chr6:31324711
rs2596492
- 0.2058 -
10_ALA THR 4.7kJPN
chr6:29795850
rs201957061
- 0.0012 -
11_ALA SER 4.7kJPN
chr6:31239616
rs1050445
- 0.331 -
11_SER ALA 4.7kJPN
chr6:31324705
rs1131170
- 0.7055 -
12_VAL MET 4.7kJPN
chr6:31239613
rs2308538
- 0.036 -
12_VAL MET 4.7kJPN
chr6:31324702
rs1050486
- 0.7057 -
13_SER CYS 4.7kJPN
chr6:29795860
-
- 0.0001 -
14_ARG TRP 4.7kJPN
chr6:29910572
rs45569434
- 0.0006 -
14_ARG TRP 4.7kJPN
chr6:31239607
rs41542423
- 0.0421 -
16_GLY SER 4.7kJPN
chr6:31239601
rs151341100
- 0.0003 -
17_ARG SER 4.7kJPN
chr6:29910581
rs1059423
- 0.145 -
17_ARG SER 4.7kJPN
chr6:31239598
rs41555420
- 0.0016 -
18_GLY GLU 4.7kJPN
chr6:29910585
rs41560112
- 0.0002 -
19_GLU LYS 4.7kJPN
chr6:29910587
rs41549014
- 0.0009 -
21_ARG HIS 4.7kJPN
chr6:29910594
rs199474366
- 0.0005 -
21_ARG HIS 4.7kJPN
chr6:31239585
rs1050437
- 0.3729 -
21_ARG GLY 4.7kJPN
chr6:31324675
rs45509993
- 0.0001 -
22_TYR CYS 4.7kJPN
chr6:29691498
-
- 0.0001 -
23_ILE SER 4.7kJPN
chr6:29910600
rs199474369
- 0.008 -
24_ALA SER 4.7kJPN
chr6:29910602
rs41552219
- 0.0015 -
24_SER ALA 4.7kJPN
chr6:31239577
rs707911
- 0.6959 -
30_ASP GLY 4.7kJPN
chr6:31324647
rs9266183
- 0.0001 -
31_THR SER 4.7kJPN
chr6:29795913
rs41551813
- 0.0107 -
32_GLN LEU 4.7kJPN
chr6:31324641
rs1050518
- 0.2665 -
35_ARG GLN 4.7kJPN
chr6:31239543
rs1050428
- 0.0945 -
41_ALA THR 4.7kJPN
chr6:31324615
rs1050529
- 0.2758 -
44_ARG LYS 4.7kJPN
chr6:29910663
rs707910
- 0.0041 -
45_GLU GLY 4.7kJPN
chr6:31324602
rs41562914
- 0.1092 -
45_GLU LYS 4.7kJPN
chr6:31324603
rs9266178
- 0.2635 -
46_GLU ALA 4.7kJPN
chr6:31239510
rs281860371
- 0.0096 -
46_GLU ALA 4.7kJPN
chr6:31324599
rs1050538
- 0.1643 -
48_ARG PRO 4.7kJPN
chr6:29691576
rs77329802
- 0.0038 -
49_ALA GLU 4.7kJPN
chr6:31239501
rs1050409
- 0.0428 -
52_ILE MET 4.7kJPN
chr6:29910688
rs41544012
- 0.1249 -
52_VAL MET 4.7kJPN
chr6:31239493
rs1065382
- 0.0119 -
52_ILE MET 4.7kJPN
chr6:31324580
rs143961508
- 0.0671 -
52_ILE VAL 4.7kJPN
chr6:31324582
rs145974360
- 0.0671 -
54_GLN ARG 4.7kJPN
chr6:29910693
rs41559716
- 0.0017 -
56_GLY ARG 4.7kJPN
chr6:29910698
rs1059449
- 0.0917 -
56_GLY GLU 4.7kJPN
chr6:29910699
rs1059451
- 0.1227 -
62_GLU GLY VAR_004356 -
Polymorphism - -
62_GLU GLN 4.7kJPN
chr6:29796006
-
- 0.0001 -
62_GLN GLU 4.7kJPN
chr6:29910716
rs1059455
- 0.6046 -
62_ARG GLY 4.7kJPN
chr6:31324552
rs141484466
- 0.0047 -
63_GLU ASP 4.7kJPN
chr6:29910721
rs199474424
- 0.1936 -
63_ASN LYS 4.7kJPN
chr6:31324547
rs1065386
- 0.5696 -
63_ASN ASP 4.7kJPN
chr6:31324549
rs1050570
- 0.5695 -
64_THR ILE 4.7kJPN
chr6:31324545
rs151341182
- 0.0002 -
65_GLY ARG VAR_004357 -
Polymorphism - -
65_ARG GLY 4.7kJPN
chr6:29910725
rs199474430
- 0.3587 -
65_GLN ARG 4.7kJPN
chr6:31324542
rs1131201
- 0.0047 -
66_ASN LYS 4.7kJPN
chr6:29910730
rs199474436
- 0.6058 -
66_LYS ASN 4.7kJPN
chr6:31239449
rs28626310
- 0.0287 -
66_ILE MET 4.7kJPN
chr6:31324538
rs707909
- 0.0446 -
66_ILE ASN 4.7kJPN
chr6:31324539
rs1131202
- 0.0446 -
68_LYS GLU 4.7kJPN
chr6:31239445
rs281860401
- 0.0001 -
69_ALA THR 4.7kJPN
chr6:29910737
rs199474443
- 0.1067 -
69_ALA GLY 4.7kJPN
chr6:31324530
rs41546313
- 0.045 -
70_GLN LYS 4.7kJPN
chr6:29910740
rs554470055
- 0.107 -
70_GLN HIS 4.7kJPN
chr6:29910742
rs78306866
- 0.9065 -
70_GLN LYS 4.7kJPN
chr6:31324528
rs1071817
- 0.0021 -
71_SER ALA 4.7kJPN
chr6:29910743
rs1059467
- 0.1068 -
73_THR ILE 4.7kJPN
chr6:29910750
rs199474457
- 0.1688 -
73_ALA THR 4.7kJPN
chr6:31239430
rs41543814
- 0.704 -
74_ASP HIS 4.7kJPN
chr6:29910752
rs1136683
- 0.2755 -
74_ASP TYR 4.7kJPN
chr6:31324516
rs1131215
- 0.7357 -
76_GLU VAL 4.7kJPN
chr6:31324509
rs41553715
- 0.0468 -
77_ASP ASN 4.7kJPN
chr6:29910761
rs1136688
- 0.4636 -
77_SER ASN 4.7kJPN
chr6:31239417
rs2308557
- 0.0843 -
77_SER ASN 4.7kJPN
chr6:31324506
rs1050388
- 0.3032 -
77_SER GLY 4.7kJPN
chr6:31324507
rs1131217
- 0.0065 -
79_GLY ARG 4.7kJPN
chr6:29910767
rs1136689
- 0.4193 -
79_ARG TRP 4.7kJPN
chr6:31324501
rs72558110
- 0.0001 -
80_ASN LYS 4.7kJPN
chr6:31239407
rs17408553
- 0.0847 -
80_ASN THR 4.7kJPN
chr6:31324497
rs1131223
- 0.0083 -
82_LEU PRO 4.7kJPN
chr6:29691678
rs751837865
- 0.0003 -
82_ARG LEU 4.7kJPN
chr6:31324491
rs3180379
- 0.0123 -
84_TYR TER 4.7kJPN
chr6:29910784
rs41562119
- 0.0002 -
85_TYR CYS 4.7kJPN
chr6:31324482
rs151341200
- 0.0001 -
90_ALA ASP 4.7kJPN
chr6:29910801
rs1136692
- 0.3021 -
90_ASP ALA 4.7kJPN
chr6:31239378
rs1131123
- 0.8099 -
91_GLY ARG 4.7kJPN
chr6:31239376
rs1131122
- 0.1418 -
94_THR ALA 4.7kJPN
chr6:29796328
-
- 0.0001 -
94_THR ILE 4.7kJPN
chr6:31239116
rs1131119
- 0.3077 -
94_THR ILE 4.7kJPN
chr6:31324210
rs12721827
- 0.1614 -
95_LEU VAL VAR_015765 -
Polymorphism - -
95_LEU ILE 4.7kJPN
chr6:31324208
rs12721829
- 0.1679 -
96_GLN GLU 4.7kJPN
chr6:31324205
-
- 0.0001 -
97_MET ARG VAR_015766 -
Polymorphism - -
97_ILE ARG 4.7kJPN
chr6:29911063
rs199474485
- 0.3712 -
97_ILE MET 4.7kJPN
chr6:29911064
rs1136695
- 0.9018 -
97_ARG THR 4.7kJPN
chr6:31239107
rs2308567
- 0.0123 -
97_ARG TRP 4.7kJPN
chr6:31239108
rs1131118
- 0.3078 -
97_SER CYS 4.7kJPN
chr6:31324202
rs41556417
- 0.0001 -
99_PHE TYR VAR_015767 -
Polymorphism - -
100_GLY CYS 4.7kJPN
chr6:31324193
rs1476918609
- 0.0001 -
103_VAL LEU 4.7kJPN
chr6:31324184
rs1131112
- 0.2079 -
105_SER PRO 4.7kJPN
chr6:29911086
rs1136700
- 0.2181 -
107_GLY TRP VAR_015768 -
Polymorphism - -
107_GLY TRP 4.7kJPN
chr6:29911092
rs1136702
- 0.2419 -
110_LEU ILE 4.7kJPN
chr6:29796376
rs12722477
- 0.4222 -
112_GLY GLU 4.7kJPN
chr6:29911108
rs199474502
- 0.0001 -
112_GLY ARG 4.7kJPN
chr6:31239063
rs41562320
- 0.0002 -
113_HIS TYR 4.7kJPN
chr6:31324154
rs1050379
- 0.0865 -
114_ASP ASN 4.7kJPN
chr6:31239057
rs2308575
- 0.1588 -
115_GLN ARG 4.7kJPN
chr6:29911117
rs41560122
- 0.0001 -
116_SER ALA 4.7kJPN
chr6:31239051
rs41553719
- 0.0007 -
116_TYR TER 4.7kJPN
chr6:31324143
rs12697944
- 0.1262 -
116_TYR ASP 4.7kJPN
chr6:31324145
rs9266150
- 0.0702 -
118_TYR TER 4.7kJPN
chr6:29692032
rs3087327
- 0.0058 -
127_ASN LYS 4.7kJPN
chr6:29911154
rs1059509
- 0.6069 -
128_GLU GLY 4.7kJPN
chr6:29796431
-
- 0.0001 -
131_ARG SER 4.7kJPN
chr6:31239006
rs76907552
- 0.1291 -
131_ARG SER 4.7kJPN
chr6:31324100
rs1050654
- 0.6952 -
138_MET LYS 4.7kJPN
chr6:29911186
rs41549316
- 0.0007 -
138_THR ASN 4.7kJPN
chr6:31238984
rs2308584
- 0.0043 -
138_THR LYS 4.7kJPN
chr6:31324078
rs1050368
- 0.0002 -
142_ILE THR 4.7kJPN
chr6:29911198
rs1059516
- 0.2488 -
143_THR SER 4.7kJPN
chr6:31324064
rs41541519
- 0.0866 -
144_LYS ARG 4.7kJPN
chr6:29796479
-
- 0.0001 -
144_LYS GLN 4.7kJPN
chr6:29911203
rs1059517
- 0.2978 -
144_GLN ARG 4.7kJPN
chr6:31238966
rs281860502
- 0.0003 -
144_GLN ARG 4.7kJPN
chr6:31324060
rs151341283
- 0.0001 -
145_ARG HIS 4.7kJPN
chr6:29911207
rs1059520
- 0.2444 -
145_ARG LEU 4.7kJPN
chr6:31324057
rs12697943
- 0.0128 -
147_LEU TRP 4.7kJPN
chr6:31238957
rs1050366
- 0.8635 -
147_TRP LEU 4.7kJPN
chr6:31324051
rs41551018
- 0.0869 -
149_ALA THR 4.7kJPN
chr6:29911218
rs1059526
- 0.1256 -
150_ALA VAL 4.7kJPN
chr6:29911222
rs1059535
- 0.0038 -
151_HIS TYR 4.7kJPN
chr6:29911224
rs41562118
- 0.0002 -
151_HIS ARG 4.7kJPN
chr6:29911225
rs1059536
- 0.1659 -
152_GLU TER 4.7kJPN
chr6:29911227
rs1059537
- 0.0023 -
152_ALA THR 4.7kJPN
chr6:31238943
rs41552817
- 0.0897 -
152_GLU VAL 4.7kJPN
chr6:31324036
rs151341293
- 0.5359 -
156_GLN TRP VAR_004358 -
Polymorphism - -
156_GLN LEU VAR_015769 -
Polymorphism - -
156_LEU ARG 4.7kJPN
chr6:31238930
rs2308592
- 0.4048 -
156_ARG LEU 4.7kJPN
chr6:31324024
rs697742
- 0.7588 -
156_ARG TRP 4.7kJPN
chr6:31324025
rs9266144
- 0.165 -
157_ARG THR 4.7kJPN
chr6:29911243
rs41551921
- 0.0017 -
158_ALA VAL 4.7kJPN
chr6:29911246
rs9260157
- 0.0038 -
158_ALA THR 4.7kJPN
chr6:31238925
rs141142418
- 0.0379 -
158_ALA VAL 4.7kJPN
chr6:31324018
rs41542712
- 0.0001 -
158_ALA THR 4.7kJPN
chr6:31324019
rs1050683
- 0.0348 -
160_LEU MET 4.7kJPN
chr6:31238919
rs41561720
- 0.0001 -
161_ASP GLU 4.7kJPN
chr6:29911256
rs1059542
- 0.9937 -
162_GLY SER 4.7kJPN
chr6:29796532
-
- 0.0001 -
163_THR ARG VAR_015770 -
Polymorphism - -
163_THR PRO 4.7kJPN
chr6:29911260
rs543623321
- 0.2021 -
163_THR ARG 4.7kJPN
chr6:29911261
rs3129017
- 0.2346 -
166_GLU ASP 4.7kJPN
chr6:29911271
rs879577815
- 0.3594 -
167_TRP SER 4.7kJPN
chr6:31238897
rs150127748
- 0.0211 -
167_TRP SER 4.7kJPN
chr6:31323991
rs1050692
- 0.0687 -
169_ARG SER 4.7kJPN
chr6:31323986
rs41558514
- 0.0004 -
171_TYR HIS 4.7kJPN
chr6:31238886
rs77935220
- 0.0052 -
171_TYR HIS 4.7kJPN
chr6:31323980
rs1050696
- 0.193 -
173_GLU LYS 4.7kJPN
chr6:31238880
rs1050357
- 0.2662 -
173_GLU LYS 4.7kJPN
chr6:31323974
rs41545114
- 0.0017 -
175_GLY ARG 4.7kJPN
chr6:29911296
rs41559916
- 0.1974 -
175_GLY ARG 4.7kJPN
chr6:31238874
rs41552417
- 0.0147 -
177_GLU LYS 4.7kJPN
chr6:31238868
rs1131103
- 0.1057 -
177_ASP GLU 4.7kJPN
chr6:31323960
rs1131275
- 0.8643 -
178_THR MET 4.7kJPN
chr6:29911306
rs9391665
- 0.1996 -
178_LYS THR 4.7kJPN
chr6:31323958
rs1131279
- 0.8646 -
180_GLU GLN 4.7kJPN
chr6:31323953
rs1131285
- 0.8651 -
181_ARG HIS VAR_056263 rs17185861
Polymorphism - -
181_ARG HIS 4.7kJPN
chr6:29911315
rs17185861
- 0.0001 -
182_THR ALA VAR_004360 -
Polymorphism - -
183_ASP GLU 4.7kJPN
chr6:29797196
rs756079304
- 0.0001 -
183_ASP GLU 4.7kJPN
chr6:31323368
rs746030903
- 0.0062 -
184_PRO HIS 4.7kJPN
chr6:31238259
rs1131096
- 0.8629 -
184_PRO HIS 4.7kJPN
chr6:31323366
rs199875334
- 0.0063 -
185_PRO SER 4.7kJPN
chr6:29797200
-
- 0.0001 -
193_PRO ALA 4.7kJPN
chr6:29911928
rs1059563
- 0.4373 -
194_ILE VAL 4.7kJPN
chr6:29911931
rs9260179
- 0.4376 -
194_LEU VAL 4.7kJPN
chr6:31238230
rs1050716
- 0.8632 -
194_ILE VAL 4.7kJPN
chr6:31323337
rs1050341
- 0.2877 -
199_ALA VAL 4.7kJPN
chr6:31323321
rs1050723
- 0.0676 -
200_THR SER 4.7kJPN
chr6:29911950
-
- 0.0002 -
207_GLY ALA 4.7kJPN
chr6:29692880
-
- 0.0003 -
207_GLY SER 4.7kJPN
chr6:29911970
rs9260180
- 0.5131 -
209_TYR CYS 4.7kJPN
chr6:31323291
-
- 0.0001 -
211_ALA THR 4.7kJPN
chr6:31238179
rs41562012
- 0.0003 -
219_ARG GLN 4.7kJPN
chr6:29797303
rs79984266
- 0.0001 -
219_ARG TRP 4.7kJPN
chr6:31238155
rs1050328
- 0.6245 -
219_ARG TRP 4.7kJPN
chr6:31323262
rs77665001
- 0.0272 -
222_GLU GLY 4.7kJPN
chr6:31238145
-
- 0.0001 -
226_GLN TER 4.7kJPN
chr6:29797323
rs144753960
- 0.0034 -
227_ASP HIS 4.7kJPN
chr6:29912030
rs145046067
- 0.0404 -
231_VAL MET 4.7kJPN
chr6:29912042
rs150028516
- 0.0238 -
236_ALA VAL 4.7kJPN
chr6:31323210
rs41543613
- 0.0015 -
239_ARG GLY 4.7kJPN
chr6:31323202
rs41545916
- 0.0434 -
240_THR ILE 4.7kJPN
chr6:29912070
rs41548917
- 0.0001 -
240_THR ASN 4.7kJPN
chr6:31323198
-
- 0.0001 -
244_TRP ARG 4.7kJPN
chr6:29797377
-
- 0.0001 -
245_ALA VAL 4.7kJPN
chr6:29912085
rs148794540
- 0.0004 -
245_ALA THR 4.7kJPN
chr6:31323184
rs2308488
- 0.0306 -
246_ALA PRO 4.7kJPN
chr6:29797383
rs1231277366
- 0.0002 -
246_ALA SER 4.7kJPN
chr6:29912087
rs1059632
- 0.2944 -
248_VAL MET 4.7kJPN
chr6:31238068
rs1050276
- 0.1679 -
248_VAL MET 4.7kJPN
chr6:31323175
rs41558116
- 0.0063 -
250_PRO LEU 4.7kJPN
chr6:29912100
rs770552939
- 0.0001 -
251_PRO SER 4.7kJPN
chr6:29693011
rs1736924
- 0.9955 -
253_GLU GLN 4.7kJPN
chr6:29912108
rs2231095
- 0.529 -
253_GLN GLU 4.7kJPN
chr6:31238053
rs707908
- 0.8598 -
257_TYR ASN 4.7kJPN
chr6:29693029
-
- 0.0001 -
257_TYR TER 4.7kJPN
chr6:29912122
rs41555316
- 0.0002 -
258_THR MET 4.7kJPN
chr6:29797420
rs12722482
- 0.004 -
261_MET ILE 4.7kJPN
chr6:31238027
rs41540117
- 0.0413 -
261_MET VAL 4.7kJPN
chr6:31238029
rs2308622
- 0.8599 -
264_GLU LYS 4.7kJPN
chr6:29693050
-
- 0.0001 -
265_GLY VAL 4.7kJPN
chr6:29797441
-
- 0.0001 -
267_GLN PRO 4.7kJPN
chr6:31238010
rs1131015
- 0.8601 -
268_LYS GLU 4.7kJPN
chr6:29912153
rs1136835
- 0.0096 -
268_LYS GLU 4.7kJPN
chr6:31323115
rs41541515
- 0.0492 -
269_PRO LEU 4.7kJPN
chr6:29912157
rs550984689
- 0.002 -
273_SER ARG 4.7kJPN
chr6:31237991
rs2308628
- 0.8605 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.