PDB ID 3E7A     CHAIN A
Protein name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Uniprot Accession P62136
The number of similar proteins 34
The number of binding states 12
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3E7A (CHAIN: A)
1 Monomeric state
2 O35274  
3 O55000  
4 O75807  
5 Q69YH5  
6 Q12972  
7 P62136  
8 Q9DCL8  
9 Q5SWA1  
10 Q90624  
11 P62136   O35867  
12 P62136   O35867   O35867  

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Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GHMGSLNLDS   IIGRLLEVQG   SRPGKNVQLT   ENEIRGLCLK   SREIFLSQPI   50
51   LLELEAPLKI   CGDIHGQYYD   LLRLFEYGGF   PPESNYLFLG   DYVDRGKQSL   100
101   ETICLLLAYK   IKYPENFFLL   RGNHECASIN   RIYGFYDECK   RRYNIKLWKT   150
151   FTDCFNCLPI   AAIVDEKIFC   CHGGLSPDLQ   SMEQIRRIMR   PTDVPDQGLL   200
201   CDLLWSDPDK   DVQGWGENDR   GVSFTFGAEV   VAKFLHKHDL   DLICRAHQVV   250
251   EDGYEFFAKR   QLVTLFSAPN   YCGEFDNAGA   MMSVDETLMC   SFQILKPAD   300

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
10_ASP GLY 4.7kJPN
chr11:67169225
rs766387418
- 0.0001 -
12_ILE THR 4.7kJPN
chr11:67169219
-
- 0.0003 -
43_ARG CYS 4.7kJPN
chr12:111169635
-
- 0.0001 -
50_PRO ARG ClinVar
chr2:28999810
rs886037952
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
50_PRO ARG 4.7kJPN
chr11:67168577
-
- 0.0001 -
57_ALA PRO ClinVar
chr2:28999830
rs1114167429
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]
74_ARG GLN 4.7kJPN
chr12:111168531
rs1212732502
- 0.0001 -
86_ASN LYS ClinVar
chr2:29001745
rs1553310744
Likely pathogenic - not provided [MedGen:CN517202]
100_SER ALA 4.7kJPN
chr11:67168280
-
- 0.0001 -
111_LYS GLU 4.7kJPN
chr11:67168247
-
- 0.0001 -
112_ILE VAL 4.7kJPN
chr11:67168244
rs1298016292
- 0.0001 -
129_SER THR 4.7kJPN
chr11:67168192
-
- 0.0001 -
184_GLU ALA ClinVar
chr2:29006800
rs886037954
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
184_GLU VAL ClinVar
chr2:29006800
rs886037954
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
221_ARG CYS ClinVar
chr2:29011589
rs1553311527
Likely pathogenic - not provided [MedGen:CN517202]
230_GLU LYS 4.7kJPN
chr11:67166470
rs1204847934
- 0.0001 -
245_CYS TYR 4.7kJPN
chr12:111160290
rs1260548492
- 0.0001 -
253_ASP TYR ClinVar
chr2:29016738
rs886037953
Likely pathogenic - not provided [MedGen:CN517202]
257_PHE ILE 4.7kJPN
chr11:67166306
rs1284030697
- 0.0071 -
275_GLU LYS ClinVar
chr2:29016804
rs886037955
Likely pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.