PDB ID 3E7A     CHAIN A
Protein name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Uniprot Accession P62136
The number of similar proteins 34
The number of binding states 12
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3E7A (CHAIN: A)
1 Monomeric state
2 O35274  
3 O55000  
4 O75807  
5 Q69YH5  
6 Q12972  
7 P62136  
8 Q9DCL8  
9 Q5SWA1  
10 Q90624  
11 P62136   O35867  
12 P62136   O35867   O35867  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GHMGSLNLDS   IIGRLLEVQG   SRPGKNVQLT   ENEIRGLCLK   SREIFLSQPI   50
51   LLELEAPLKI   CGDIHGQYYD   LLRLFEYGGF   PPESNYLFLG   DYVDRGKQSL   100
101   ETICLLLAYK   IKYPENFFLL   RGNHECASIN   RIYGFYDECK   RRYNIKLWKT   150
151   FTDCFNCLPI   AAIVDEKIFC   CHGGLSPDLQ   SMEQIRRIMR   PTDVPDQGLL   200
201   CDLLWSDPDK   DVQGWGENDR   GVSFTFGAEV   VAKFLHKHDL   DLICRAHQVV   250
251   EDGYEFFAKR   QLVTLFSAPN   YCGEFDNAGA   MMSVDETLMC   SFQILKPAD   300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
10_ASP GLY 8.3kJPN
chr11:67169225 		rs766387418
- 0.0001 -
12_ILE THR 8.3kJPN
chr11:67169219 		-
- 0.0002 -
43_ARG CYS 8.3kJPN
chr12:111169635 		-
- 0.0001 -
50_PRO ARG ClinVar
chr2:28999810 		rs886037952
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
50_PRO ARG 8.3kJPN
chr11:67168577 		-
- 0.0001 -
57_ALA PRO ClinVar
chr2:28999830 		rs1114167429
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]
74_ARG GLN 8.3kJPN
chr12:111168531 		rs1212732502
- 0.0001 -
86_ASN LYS ClinVar
chr2:29001745 		rs1553310744
Likely pathogenic - not provided [MedGen:CN517202]
100_SER ALA 8.3kJPN
chr11:67168280 		-
- 0.0001 -
111_LYS GLU 8.3kJPN
chr11:67168247 		-
- 0.0001 -
118_PHE LEU 8.3kJPN
chr2:29001839 		-
- 0.0001 -
162_ALA THR 8.3kJPN
chr12:111162504 		rs1377289520
- 0.0001 -
184_GLU ALA ClinVar
chr2:29006800 		rs886037954
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
184_GLU VAL ClinVar
chr2:29006800 		rs886037954
Pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
187_ARG GLN 8.3kJPN
chr12:111160464 		rs1276219223
- 0.0001 -
221_ARG CYS ClinVar
chr2:29011589 		rs1553311527
Likely pathogenic - not provided [MedGen:CN517202]
230_GLU LYS 8.3kJPN
chr11:67166470 		rs1204847934
- 0.0001 -
245_CYS TYR 8.3kJPN
chr12:111160290 		rs1260548492
- 0.0001 -
253_ASP TYR ClinVar
chr2:29016738 		rs886037953
Likely pathogenic - not provided [MedGen:CN517202]
257_PHE ILE 8.3kJPN
chr11:67166306 		rs1284030697
- 0.0042 -
275_GLU LYS ClinVar
chr2:29016804 		rs886037955
Likely pathogenic - Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.