PDB ID 3E4Z     CHAIN A
Protein name Insulin-degrading enzyme
Uniprot Accession Q5T5N2
The number of similar proteins 53
The number of binding states 14
The number of binding partners 11

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3E4Z (CHAIN: A)
1 P01344  
2 Monomeric state
3 P01308  
4 P10147  
5 P16860  
6 P14735  
7 P0CG48  
8 P10997  
9 P01135  
10 2G47  
11 4M1C   P05067  
12 P14735   5WOB  
13 5UOE   5UOE  
14 P14735   5CJO   5CJO  

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Molecule viewer

#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MHHHHHHAAG   IPMNNPAIKR   IGNHITKSPE   DKREYRGLEL   ANGIKVLLIS   50
51   DPTTDKSSAA   LDVHIGSLSD   PPNIAGLSHF   LQHMLFLGTK   KYPKENEYSQ   100
101   FLSEHAGSSN   AFTSGEHTNY   YFDVSHEHLE   GALDRFAQFF   LSPLFDESAK   150
151   DREVNAVDSE   HEKNVMNDAW   RLFQLEKATG   NPKHPFSKFG   TGNKYTLETR   200
201   PNQEGIDVRQ   ELLKFHSAYY   SSNLMAVVVL   GRESLDDLTN   LVVKLFSEVE   250
251   NKNVPLPEFP   EHPFQEEHLK   QLYKIVPIKD   IRNLYVTFPI   PDLQKYYKSN   300
301   PGHYLGHLIG   HEGPGSLLSE   LKSKGWVNTL   VGGQKEGARG   FMFFIINVDL   350
351   TEEGLLHVED   IILHMFQYIQ   KLRAEGPQEW   VFQELKDLNA   VAFRFKDKER   400
401   PRGYTSKIAG   ILHYYPLEEV   LTAEYLLEEF   RPDLIEMVLD   KLRPENVRVA   450
451   IVSKSFEGKT   DRTEEWYGTQ   YKQEAIPDEV   IKKWQNADLN   GKFKLPTKNE   500
501   FIPTNFEILP   LEKEATPYPA   LIKDTAMSKL   WFKQDDKFFL   PKANLNFEFF   550
551   SPFAYVDPLH   SNMAYLYLEL   LKDSLNEYAY   AAELAGLSYD   LQNTIYGMYL   600
601   SVKGYNDKQP   ILLKKIIEKM   ATFEIDEKRF   EIIKEAYMRS   LNNFRAEQPH   650
651   QHAMYYLRLL   MTEVAWTKDE   LKEALDDVTL   PRLKAFIPQL   LSRLHIEALL   700
701   HGNITKQAAL   GIMQMVEDTL   IEHAHTKPLL   PSQLVRYREV   QLPDRGWFVY   750
751   QQRNEVHNNS   GIEIYYQTDM   QSTSENMFLE   LFAQIISEPA   FNTLRTKEQL   800
801   GYIVFSGPRR   ANGIQGLRFI   IQSEKPPHYL   ESRVEAFLIT   MEKSIEDMTE   850
851   EAFQKHIQAL   AIRRLDKPKK   LSAESAKYYG   EIISQQYNFD   RDNTEVAYLK   900
901   TLTKEDIIKF   YKEMLAVDAP   RRHKVSVHVL   AREMDSCPVV   GEFPCQNDIN   950
951   LSQAPALPQP   EVIQNMTEFK   RGLPLFPLVK   PHINFMAAKL     1000

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
50_ILE THR 4.7kJPN
chr10:94297257
rs780598235
- 0.0012 -
51_GLY ARG 4.7kJPN
chr10:94297255
-
- 0.0001 -
181_ARG LYS 4.7kJPN
chr10:94291624
rs1346925336
- 0.0001 -
191_GLU LYS 4.7kJPN
chr10:94291595
-
- 0.0001 -
202_PHE LEU 4.7kJPN
chr10:94291562
-
- 0.0001 -
260_GLY SER 4.7kJPN
chr10:94274683
rs192563243
- 0.0005 -
402_ARG LEU 4.7kJPN
chr10:94267372
rs775329426
- 0.0007 -
443_TYR HIS 4.7kJPN
chr10:94264654
rs1275159763
- 0.0001 -
477_ARG TRP 4.7kJPN
chr10:94264552
rs759169186
- 0.0002 -
484_SER CYS 4.7kJPN
chr10:94250332
rs117251230
- 0.0131 -
490_ASP ASN 4.7kJPN
chr10:94250315
-
- 0.0001 -
498_THR ILE 4.7kJPN
chr10:94250290
-
- 0.0003 -
524_LEU PHE 4.7kJPN
chr10:94247039
rs1471469075
- 0.0002 -
539_PRO LEU 4.7kJPN
chr10:94246993
rs147012131
- 0.0002 -
617_SER ASN 4.7kJPN
chr10:94239068
-
- 0.0001 -
644_LYS ASN 4.7kJPN
chr10:94235704
-
- 0.0001 -
722_ARG GLN 4.7kJPN
chr10:94230054
rs1212879700
- 0.0002 -
765_ARG TRP 4.7kJPN
chr10:94228663
rs760053435
- 0.0003 -
778_VAL LEU 4.7kJPN
chr10:94225589
-
- 0.0001 -
865_ALA THR 4.7kJPN
chr10:94223656
rs761870451
- 0.0002 -
891_ILE VAL 4.7kJPN
chr10:94223578
rs753087364
- 0.0001 -
956_VAL ILE 4.7kJPN
chr10:94216146
rs375559999
- 0.0018 -
1010_PRO LEU 4.7kJPN
chr10:94214232
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.