PDB ID 3CAF     CHAIN A
Protein name Fibroblast growth factor receptor 2
Uniprot Accession P21802
The number of similar proteins 6
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3CAF (CHAIN: A)
1 P21802  
2 Monomeric state
3 4WV1   4WV1  
4 P21802   P05230   P05230  

Downdload

Format:

Molecule viewer

#binding
partners
  2
  1
  0

Sequence information

1   NKRAPYWTNT   EKMEKRLHAV   PAANTVKFRC   PAGGNPMPTM   RWLKNGKEFK   50
51   QEHRIGGYKV   RNQHWSLIME   SVVPSDKGNY   TCVVENEYGS   INHTYHLDVV   100

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
166_LEU SER ClinVar
chr8:38285566
rs397515481
Pathogenic - Hartsfield syndrome [MedGen:C1845146,OMIM:615465,Orphanet:ORPHA2117]
168_ALA SER ClinVar
chr8:38285561
rs121909630
Pathogenic - Hypogonadotropic hypogonadism 2 with anosmia [MedGen:C4016104]
172_ALA PHE VAR_017259 -
Disease - Pfeiffer syndrome (PS) [MIM:101600]
178_ARG HIS 4.7kJPN
chr10:123310895
rs141796960
- 0.0001 -
178_ARG CYS 4.7kJPN
chr10:123310896
rs974173968
- 0.0001 -
186_MET THR VAR_017260 rs755793
Polymorphism - -
186_MET THR 4.7kJPN
chr10:123310871
rs755793
- 0.0652 -
186_MET VAL 4.7kJPN
chr10:123310872
rs55977237
- 0.0002 -
190_ARG CYS ClinVar
chr8:38285495
rs863223331
Pathogenic - Kallmann syndrome 2 [MedGen:C1563720,OMIM:147950]
192_LEU SER ClinVar
chr8:38285488
rs869025669
Pathogenic - Hartsfield syndrome [MedGen:C1845146,OMIM:615465,Orphanet:ORPHA2117]
203_ARG CYS VAR_036380 -
Unclassified - Breast cancer samples
210_ARG CYS ClinVar
chr8:38283760
rs1554564353
Likely pathogenic - Kallmann syndrome 2 [MedGen:C1563720,OMIM:147950]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.