PDB ID 2ZVO     CHAIN B
Protein name NF-kappa-B essential modulator
Uniprot Accession O88522
The number of similar proteins 12
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   GSGMQLEDLR   QQLQQAEEAL   VAKQELIDKL   KEEAAQHAIV   METVPVLKAQ   50
51   ADIYKADFQA   ERHAREKLVE   KKEYLQEQLE   QLQREFNKLK   VG   100

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
281_ALA GLY ClinVar
chrX:153791119
rs137853330
Pathogenic - Hypohidrotic ectodermal dysplasia with immune deficiency [MedGen:C1846006,OMIM:300291,Orphanet:ORPHA98813]
283_GLN TER ClinVar
chrX:153791124
rs1156900338
Pathogenic - not provided [MedGen:CN517202]
304_ASP ASN ClinVar
chrX:153791792
rs179363867
Likely pathogenic - Hypohidrotic ectodermal dysplasia with immune deficiency [MedGen:C1846006,OMIM:300291,Orphanet:ORPHA98813]; not provided [MedGen:CN517202]
308_GLU ALA ClinVar
chrX:153791805
rs137853331
Pathogenic - Familial atypical mycobacteriosis, type 1, X-linked [MedGen:C1970879,OMIM:300636,Orphanet:ORPHA319612]
312_ARG GLN ClinVar
chrX:153791817
rs137853332
Pathogenic - Familial atypical mycobacteriosis, type 1, X-linked [MedGen:C1970879,OMIM:300636,Orphanet:ORPHA319612]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.