PDB ID 2WII     CHAIN A
Protein name COMPLEMENT C3 BETA CHAIN
Uniprot Accession P01024
The number of similar proteins 25
The number of binding states 10
The number of binding partners 11

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2WII (CHAIN: A)
1 Q76U65   P01024  
2 P01024  
3 P01024   P00751  
4 P01024   P01024  
5 P01024   Q9Y279  
6 P01024   P01024   2WIN  
7 Q931M7   P01024   P01024  
8 P01024   3G6J   3G6J  
9 P01024   P01024   Q9Y279  
10 P08603   P08603   P01024   P05156  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   SPMYSIITPN   ILRLESEETM   VLEAHDAQGD   VPVTVTVHDF   PGKKLVLSSE   50
51   KTVLTPATNH   MGNVTFTIPA   NREFKSEKGR   NKFVTVQATF   GTQVVEKVVL   100
101   VSLQSGYLFI   QTDKTIYTPG   STVLYRIFTV   NHKLLPVGRT   VMVNIENPEG   150
151   IPVKQDSLSS   QNQLGVLPLS   WDIPELVNMG   QWKIRAYYEN   SPQQVFSTEF   200
201   EVKEYVLPSF   EVIVEPTEKF   YYIYNEKGLE   VTITARFLYG   KKVEGTAFVI   250
251   FGIQDGEQRI   SLPESLKRIP   IEDGSGEVVL   SRKVLLDGVQ   NPRAEDLVGK   300
301   SLYVSATVIL   HSGSDMVQAE   RSGIPIVTSP   YQIHFTKTPK   YFKPGMPFDL   350
351   MVFVTNPDGS   PAYRVPVAVQ   GEDTVQSLTQ   GDGVAKLSIN   THPSQKPLSI   400
401   TVRTKKQELS   EAEQATRTMQ   ALPYSTVGNS   NNYLHLSVLR   TELRPGETLN   450
451   VNFLLRMDRA   HEAKIRYYTY   LIMNKGRLLK   AGRQVREPGQ   DLVVLPLSIT   500
501   TDFIPSFRLV   AYYTLIGASG   QREVVADSVW   VDVKDSCVGS   LVVKSGQSED   550
551   RQPVPGQQMT   LKIEGDHGAR   VVLVAVDKGV   FVLNKKNKLT   QSKIWDVVEK   600
601   ADIGCTPGSG   KDYAGVFSDA   GLTFTSSSGQ   QTAQRAELQC   PQPAA   650

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_SER CYS 8.3kJPN
chr19:6720534 		-
- 0.0001 -
36_THR ILE 8.3kJPN
chr19:6719316 		-
- 0.0001 -
38_HIS GLN 8.3kJPN
chr19:6719309 		-
- 0.0001 -
43_LYS GLN ClinVar
chr19:6719296 		rs539992721
Likely pathogenic - not provided [MedGen:CN517202]
66_PHE LEU 8.3kJPN
chr19:6719225 		-
- 0.0001 -
72_ARG LYS 8.3kJPN
chr19:6718410 		-
- 0.0001 -
80_ARG GLY VAR_001983 rs2230199
Polymorphism - -
80_ARG GLY gnomAD
chr19:6718387 		rs2230199
- 0.15049 -
80_ARG CYS 8.3kJPN
chr19:6718387 		-
- 0.0001 -
90_PHE VAL 8.3kJPN
chr19:6718357 		-
- 0.0001 -
100_LEU PRO 8.3kJPN
chr19:6718326 		rs768598098
- 0.0004 -
133_LYS GLN VAR_070941 rs147859257
Disease - Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]
133_LYS GLN gnomAD
chr19:6718146 		rs147859257
- 0.00279176 -
175_GLU GLN 8.3kJPN
chr19:6714373 		-
- 0.0001 -
177_VAL ILE 8.3kJPN
chr19:6714367 		rs147549358
- 0.0001 -
192_PRO SER ClinVar
chr19:6714219 		rs794729228
Likely pathogenic - Atypical hemolytic-uremic syndrome 5 [MedGen:C2752037,OMIM:612925,Orphanet:ORPHA93575]
200_PHE LEU 8.3kJPN
chr19:6714193 		-
- 0.0001 -
209_SER ASN 8.3kJPN
chr19:6714084 		rs1397744538
- 0.0002 -
227_LYS ARG 8.3kJPN
chr19:6714030 		-
- 0.001 -
250_ILE VAL 8.3kJPN
chr19:6713480 		-
- 0.0001 -
253_ILE THR 8.3kJPN
chr19:6713470 		-
- 0.0001 -
292_PRO LEU VAR_001984 rs1047286
Polymorphism - -
292_PRO LEU gnomAD
chr19:6713262 		rs1047286
- 0.141462 -
304_VAL MET 8.3kJPN
chr19:6713227 		rs375264020
- 0.0001 -
381_GLY ARG 8.3kJPN
chr19:6712330 		-
- 0.0002 -
403_ARG CYS gnomAD
chr19:6711204 		rs200967589
- 0.000222577 -
403_ARG CYS 8.3kJPN
chr19:6711204 		rs200967589
- 0.0011 -
404_THR MET 8.3kJPN
chr19:6711200 		rs750670528
- 0.0001 -
427_VAL MET 8.3kJPN
chr19:6711132 		rs778633133
- 0.0002 -
429_ASN SER 8.3kJPN
chr19:6711125 		rs749155541
- 0.0002 -
432_ASN LYS 8.3kJPN
chr19:6711115 		-
- 0.0001 -
440_ARG CYS 8.3kJPN
chr19:6711093 		rs1406717691
- 0.0001 -
446_GLY ARG 8.3kJPN
chr19:6711075 		rs148820222
- 0.0001 -
447_GLU ASP VAR_020262 rs11569422
Polymorphism - -
447_GLU ASP gnomAD
chr19:6711070 		rs11569422
- 0.00333222 -
481_ALA VAL 8.3kJPN
chr19:6710828 		rs781417846
- 0.0004 -
527_ASP ASN VAR_001985 rs1449441916
Disease - Complement component 3 deficiency (C3D) [MIM:613779]
527_ASP ASN 8.3kJPN
chr19:6710691 		rs1449441916
- 0.0001 -
535_ASP ASN 8.3kJPN
chr19:6710667 		-
- 0.0001 -
540_SER LEU 8.3kJPN
chr19:6710651 		rs200541526
- 0.0048 -
551_ARG GLN 8.3kJPN
chr19:6709822 		rs780877533
- 0.0001 -
570_ARG GLN VAR_063213 rs121909583
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
570_ARG TRP VAR_063214 rs771353792
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
581_PHE VAL VAR_063654 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
597_VAL MET gnomAD
chr19:6707931 		rs146613648
- 0.000299069 -
603_ILE PHE gnomAD
chr19:6707913 		rs144432231
- 0.000430118 -
611_LYS ARG gnomAD
chr19:6707888 		rs140655115
- 0.000441858 -
614_ALA SER 8.3kJPN
chr19:6707880 		rs145886287
- 0.0016 -
615_GLY ARG gnomAD
chr19:6707877 		rs149850773
- 0.000238911 -
620_ALA SER 8.3kJPN
chr19:6707862 		rs774155819
- 0.0001 -
625_THR MET 8.3kJPN
chr19:6707846 		rs1447175740
- 0.0007 -
630_GLN PRO 8.3kJPN
chr19:6707831 		rs748054406
- 0.0002 -
633_ALA THR 8.3kJPN
chr19:6707823 		rs1220580146
- 0.0014 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.