PDB ID 2WII     CHAIN A
Protein name COMPLEMENT C3 BETA CHAIN
Uniprot Accession P01024
The number of similar proteins 25
The number of binding states 10
The number of binding partners 11

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer

#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   SPMYSIITPN   ILRLESEETM   VLEAHDAQGD   VPVTVTVHDF   PGKKLVLSSE   50
51   KTVLTPATNH   MGNVTFTIPA   NREFKSEKGR   NKFVTVQATF   GTQVVEKVVL   100
101   VSLQSGYLFI   QTDKTIYTPG   STVLYRIFTV   NHKLLPVGRT   VMVNIENPEG   150
151   IPVKQDSLSS   QNQLGVLPLS   WDIPELVNMG   QWKIRAYYEN   SPQQVFSTEF   200
201   EVKEYVLPSF   EVIVEPTEKF   YYIYNEKGLE   VTITARFLYG   KKVEGTAFVI   250
251   FGIQDGEQRI   SLPESLKRIP   IEDGSGEVVL   SRKVLLDGVQ   NPRAEDLVGK   300
301   SLYVSATVIL   HSGSDMVQAE   RSGIPIVTSP   YQIHFTKTPK   YFKPGMPFDL   350
351   MVFVTNPDGS   PAYRVPVAVQ   GEDTVQSLTQ   GDGVAKLSIN   THPSQKPLSI   400
401   TVRTKKQELS   EAEQATRTMQ   ALPYSTVGNS   NNYLHLSVLR   TELRPGETLN   450
451   VNFLLRMDRA   HEAKIRYYTY   LIMNKGRLLK   AGRQVREPGQ   DLVVLPLSIT   500
501   TDFIPSFRLV   AYYTLIGASG   QREVVADSVW   VDVKDSCVGS   LVVKSGQSED   550
551   RQPVPGQQMT   LKIEGDHGAR   VVLVAVDKGV   FVLNKKNKLT   QSKIWDVVEK   600
601   ADIGCTPGSG   KDYAGVFSDA   GLTFTSSSGQ   QTAQRAELQC   PQPAA   650

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
1_SER CYS 4.7kJPN
chr19:6720534
-
- 0.0002 -
36_THR ILE 4.7kJPN
chr19:6719316
-
- 0.0001 -
43_LYS GLN ClinVar
chr19:6719296
rs539992721
Likely pathogenic - not provided [MedGen:CN517202]
66_PHE LEU 4.7kJPN
chr19:6719225
-
- 0.0001 -
80_ARG GLY VAR_001983 rs2230199
Polymorphism - -
80_ARG CYS 4.7kJPN
chr19:6718387
-
- 0.0001 -
90_PHE VAL 4.7kJPN
chr19:6718357
-
- 0.0001 -
100_LEU PRO 4.7kJPN
chr19:6718326
rs768598098
- 0.0002 -
133_LYS GLN VAR_070941 rs147859257
Disease - Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]
177_VAL ILE 4.7kJPN
chr19:6714367
rs147549358
- 0.0001 -
192_PRO SER ClinVar
chr19:6714219
rs794729228
Likely pathogenic - Atypical hemolytic-uremic syndrome 5 [MedGen:C2752037,OMIM:612925,Orphanet:ORPHA93575]
200_PHE LEU 4.7kJPN
chr19:6714193
-
- 0.0001 -
209_SER ASN 4.7kJPN
chr19:6714084
rs1397744538
- 0.0001 -
292_PRO LEU VAR_001984 rs1047286
Polymorphism - -
381_GLY ARG 4.7kJPN
chr19:6712330
-
- 0.0001 -
403_ARG CYS 4.7kJPN
chr19:6711204
rs200967589
- 0.0012 -
427_VAL MET 4.7kJPN
chr19:6711132
rs778633133
- 0.0003 -
429_ASN SER 4.7kJPN
chr19:6711125
rs749155541
- 0.0001 -
432_ASN LYS 4.7kJPN
chr19:6711115
-
- 0.0001 -
440_ARG CYS 4.7kJPN
chr19:6711093
rs1406717691
- 0.0001 -
447_GLU ASP VAR_020262 rs11569422
Polymorphism - -
479_LEU MET 4.7kJPN
chr19:6710835
-
- 0.0001 -
481_ALA VAL 4.7kJPN
chr19:6710828
rs781417846
- 0.0002 -
527_ASP ASN VAR_001985 rs1449441916
Disease - Complement component 3 deficiency (C3D) [MIM:613779]
527_ASP ASN 4.7kJPN
chr19:6710691
rs1449441916
- 0.0001 -
540_SER LEU 4.7kJPN
chr19:6710651
rs200541526
- 0.0042 -
551_ARG GLN 4.7kJPN
chr19:6709822
rs780877533
- 0.0001 -
570_ARG GLN VAR_063213 rs121909583
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
570_ARG TRP VAR_063214 rs771353792
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
581_PHE VAL VAR_063654 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
614_ALA SER 4.7kJPN
chr19:6707880
rs145886287
- 0.0021 -
625_THR MET 4.7kJPN
chr19:6707846
rs1447175740
- 0.0008 -
630_GLN PRO 4.7kJPN
chr19:6707831
rs748054406
- 0.0004 -
633_ALA THR 4.7kJPN
chr19:6707823
rs1220580146
- 0.0012 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.