PDB ID 2QXV     CHAIN A
Protein name Embryonic ectoderm development
Uniprot Accession Q921E6
The number of similar proteins 40
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2QXV (CHAIN: A)
1 Q15910  
2 Monomeric state
3 Q15910  
4 5WP3  
5 Q15022   G1KPH4  

Downdload

Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   SFKCVNSLKE   DHNQPLFGVQ   FNWHSKEGDP   LVFATVGSNR   VTLYECHSQG   50
51   EIRLLQSYVD   ADADENFYTC   AWTYDSNTSH   PLLAVAGSRG   IIRIINPITM   100
101   QCIKHYVGHG   NAINELKFHP   RDPNLLLSVS   KDHALRLWNI   QTDTLVAIFG   150
151   GVEGHRDEVL   SADYDLLGEK   IMSCGMDHSL   KLWRINSKRM   MNAIKESYDY   200
201   NPNKTNRPFI   SQKIHFPDFS   TRDIHRNYVD   CVRWLGDLIL   SKSCENAIVC   250
251   WKPGKMEDDI   DKIKPSESNV   TILGRFDYSQ   CDIWYMRFSM   DFWQKMLALG   300
301   NQVGKLYVWD   LEVEDPHKAK   CTTLTHHKCG   AAIRQTSFSR   DSSILIAVCD   350
351   DASIWRWDRL   R         400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
170_ILE THR 4.7kJPN
chr11:85967514
-
- 0.0003 -
235_ARG THR ClinVar
chr11:85975286
rs1131692176
Pathogenic - Cohen-Gibson syndrome [MedGen:C4479654,OMIM:617561]
257_HIS TYR ClinVar
chr11:85977170
rs1131692174
Pathogenic - Cohen-Gibson syndrome [MedGen:C4479654,OMIM:617561]
278_ASP ASN 4.7kJPN
chr11:85977233
rs1487912547
- 0.0004 -
294_ARG SER ClinVar
chr11:85979543
rs1131692173
Pathogenic - Cohen-Gibson syndrome [MedGen:C4479654,OMIM:617561]
294_ARG GLY ClinVar
chr11:85979541
rs1131692175
Pathogenic - Cohen-Gibson syndrome [MedGen:C4479654,OMIM:617561]
306_TRP ARG 4.7kJPN
chr11:85979577
-
- 0.0001 -
349_ASP GLU 4.7kJPN
chr11:85988126
-
- 0.0001 -
358_MET THR ClinVar
chr11:85988152
-
Likely pathogenic - Cohen-Gibson syndrome [MedGen:C4479654,OMIM:617561]
368_MET LEU 4.7kJPN
chr11:85988960
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.