PDB ID 2QTS     CHAIN A
Protein name Acid-sensing ion channel
Uniprot Accession Q1XA76
The number of similar proteins 31
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2QTS (CHAIN: A)
1 Q1XA76   Q1XA76  
2 G9I930   G9I929  
3 Q1XA76   Q1XA76   P60514   P60514  
4 Q1XA76   Q1XA76   G9I930   G9I929   G9I929  

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Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   STLHGISHIF   SYERLSLKRV   VWALCFMGSL   ALLALVCTNR   IQYYFLYPHV   50
51   TKLDEVAATR   LTFPAVTFCN   LNEFRFSRVT   KNDLYHAGEL   LALLNNRYEI   100
101   PDTQTADEKQ   LEILQDKANF   RNFKPKPFNM   LEFYDRAGHD   IREMLLSCFF   150
151   RGEQCSPEDF   KVVFTRYGKC   YTFNAGQDGK   PRLITMKGGT   GNGLEIMLDI   200
201   QQDEYLPVWG   ETDETSFEAG   IKVQIHSQDE   PPLIDQLGFG   VAPGFQTFVS   250
251   CQEQRLIYLP   PPWGDCKATT   GDSEFYDTYS   ITACRIDCET   RYLVENCNCR   300
301   MVHMPGDAPY   CTPEQYKECA   DPALDFLVEK   DNEYCVCEMP   CNVTRYGKEL   350
351   SMVKIPSKAS   AKYLAKKYNK   SEQYIGENIL   VLDIFFEALN   YETIEQKKAY   400
401   EVAGLLGDIG   GQMGLFIGAS   ILTVLELFDY   AYEVIKHR     450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
79_ASP ASN 4.7kJPN
chr12:50452781
rs780194390
- 0.0001 -
91_VAL ILE 4.7kJPN
chr12:50452817
rs1306904297
- 0.0001 -
156_ARG HIS 4.7kJPN
chr12:50453643
rs766103987
- 0.0001 -
201_GLY SER 4.7kJPN
chr12:50471035
rs746113466
- 0.0001 -
215_THR MET 4.7kJPN
chr12:50471078
rs373616682
- 0.0001 -
290_THR ALA 4.7kJPN
chr12:50472231
-
- 0.0001 -
290_THR ASN 4.7kJPN
chr12:50472232
-
- 0.0001 -
302_ASP ASN 4.7kJPN
chr12:50472273
rs774054780
- 0.0002 -
303_SER THR 4.7kJPN
chr12:50472276
rs1256624873
- 0.0001 -
306_ILE LEU 4.7kJPN
chr12:50472285
-
- 0.0001 -
315_THR MET 4.7kJPN
chr12:50472313
rs200645931
- 0.0003 -
320_GLU ASP 4.7kJPN
chr12:50472329
-
- 0.0001 -
325_ARG SER 4.7kJPN
chr12:50472342
-
- 0.0001 -
357_GLN LYS 4.7kJPN
chr12:50473705
rs200653479
- 0.0001 -
357_GLN HIS 4.7kJPN
chr12:50473707
-
- 0.0001 -
358_GLU ASP 4.7kJPN
chr12:50473710
-
- 0.0001 -
359_TYR PHE 4.7kJPN
chr12:50473712
-
- 0.0001 -
364_MET THR 4.7kJPN
chr12:50473727
-
- 0.0001 -
364_MET ILE 4.7kJPN
chr12:50473728
-
- 0.0001 -
377_MET LEU 4.7kJPN
chr12:50473765
-
- 0.0001 -
377_MET ILE 4.7kJPN
chr12:50473767
-
- 0.0001 -
379_LYS ARG 4.7kJPN
chr12:50473772
-
- 0.0001 -
410_PHE VAL 4.7kJPN
chr12:50474306
-
- 0.0001 -
449_VAL MET 4.7kJPN
chr12:50474935
rs766297074
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.