PDB ID 2LR1     CHAIN A
Protein name Apoptosis regulator BAX
Uniprot Accession Q07812
The number of similar proteins 23
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2LR1 (CHAIN: A)
1 Monomeric state
2 Q07812  
3 P55957  
4 5W5X   5W5X  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   MDGSGEQPRG   GGPTSSEQIM   KTGALLLQGF   IQDRAGRMGG   EAPELALDPV   50
51   PQDASTKKLS   ECLKRIGDEL   DSNMELQRMI   AAVDTDSPRE   VFFRVAADMF   100
101   SDGNFNWGRV   VALFYFASKL   VLKALCTKVP   ELIRTIMGWT   LDFLRERLLG   150
151   WIQDQGGWDG   LLSYFGTPTW   QTVTIFVAGV   LTASLTIWKK   MG   200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_GLY ARG 8.3kJPN
chr19:49458192 		-
- 0.0001 -
11_GLY GLU VAR_013575 rs555248599
LB/B - -
11_GLY GLU 8.3kJPN
chr19:49458217 		rs555248599
- 0.0023 -
31_ILE VAL 8.3kJPN
chr19:49458948 		-
- 0.0001 -
37_ARG GLN gnomAD
chr19:49458967 		rs751678403
- 0.000128152 -
39_GLY ARG VAR_047053 rs36017265
LB/B - -
39_GLY ARG gnomAD
chr19:49458972 		rs36017265
- 0.0002558 -
39_GLY ALA gnomAD
chr19:49458973 		rs147630961
- 0.000104002 -
39_GLY VAL gnomAD
chr19:49458973 		rs147630961
- 0.000304005 -
39_GLY ARG 8.3kJPN
chr19:49458972 		rs36017265
- 0.0001 -
39_GLY VAL 8.3kJPN
chr19:49458973 		rs147630961
- - -
44_GLU LYS 8.3kJPN
chr19:49458987 		-
- 0.0001 -
67_GLY ARG VAR_007809 rs398122513
US - A T-cell acute lymphoblastic leukemia cell line
67_GLY ARG ClinVar
chr19:49459056 		rs398122513
Pathogenic - T-cell acute lymphoblastic leukemia [Human Phenotype Ontology:HP:0006727,MONDO:MONDO:0004963,MedGen:C1961099]
72_SER GLY 8.3kJPN
chr19:49459071 		-
- 0.0001 -
83_VAL MET 8.3kJPN
chr19:49459468 		rs777326329
- 0.0002 -
88_PRO HIS 8.3kJPN
chr19:49459484 		-
- 0.0001 -
89_ARG GLN 8.3kJPN
chr19:49459487 		rs202190487
- 0.0001 -
96_ALA VAL 8.3kJPN
chr19:49459508 		-
- 0.0001 -
108_GLY VAL VAR_013576 -
US - A Burkitt lymphoma
133_ILE MET 8.3kJPN
chr19:49464096 		-
- 0.0001 -
147_ARG TRP 8.3kJPN
chr19:49464136 		rs375752615
- 0.0001 -
151_TRP CYS 8.3kJPN
chr19:49464150 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.