PDB ID 2LR1     CHAIN A
Protein name Apoptosis regulator BAX
Uniprot Accession Q07812
The number of similar proteins 20
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2LR1 (CHAIN: A)
1 Monomeric state
2 Q07812  
3 5W5X   5W5X  
4 Q07812   Q07812   Q07812  
5 Q07812   P55957   P55957  

Downdload

Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MDGSGEQPRG   GGPTSSEQIM   KTGALLLQGF   IQDRAGRMGG   EAPELALDPV   50
51   PQDASTKKLS   ECLKRIGDEL   DSNMELQRMI   AAVDTDSPRE   VFFRVAADMF   100
101   SDGNFNWGRV   VALFYFASKL   VLKALCTKVP   ELIRTIMGWT   LDFLRERLLG   150
151   WIQDQGGWDG   LLSYFGTPTW   QTVTIFVAGV   LTASLTIWKK   MG   200

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
3_GLY ARG 4.7kJPN
chr19:49458192
-
- 0.0001 -
11_GLY GLU VAR_013575 rs555248599
Polymorphism - -
11_GLY GLU 4.7kJPN
chr19:49458217
rs555248599
- 0.0022 -
39_GLY ARG VAR_047053 rs36017265
Polymorphism - -
39_GLY ALA 4.7kJPN
chr19:49458973
rs147630961
- 0.0007 -
44_GLU LYS 4.7kJPN
chr19:49458987
-
- 0.0001 -
67_GLY ARG VAR_007809 rs398122513
Unclassified - A T-cell acute lymphoblastic leukemia cell line
67_GLY ARG ClinVar
chr19:49459056
rs398122513
Pathogenic - T-cell acute lymphoblastic leukemia [Human Phenotype Ontology:HP:0006727,MedGen:C1961099,Orphanet:ORPHA99861,SNOMED CT:277575008]
72_SER GLY 4.7kJPN
chr19:49459071
-
- 0.0001 -
83_VAL MET 4.7kJPN
chr19:49459468
rs777326329
- 0.0001 -
88_PRO HIS 4.7kJPN
chr19:49459484
-
- 0.0001 -
108_GLY VAL VAR_013576 -
Unclassified - A Burkitt lymphoma
147_ARG TRP 4.7kJPN
chr19:49464136
rs375752615
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.