PDB ID 2KWF     CHAIN A
Protein name CREB-binding protein
Uniprot Accession Q92793
The number of similar proteins 12
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2KWF (CHAIN: A)
1 Monomeric state
2 2LQH  
3 P16220  
4 Q04206  
5 Q2Q067   P06876  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GVRKGWHEHV   TQDLRSHLVH   KLVQAIFPTP   DPAALKDRRM   ENLVAYAKKV   50
51   EGDMYESANS   RDEYYHLLAE   KIYKIQKELE   EKRRSRL     100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_GLY ASP 8.3kJPN
chr16:3830796 		-
- 0.0002 -
15_ARG TER ClinVar
chr22:41533772 		rs137853038
Pathogenic - Carcinoma of colon [MedGen:C0699790,OMIM:114500,SNOMED CT:269533000]
16_ASN SER 8.3kJPN
chr22:41533776 		-
- 0.0001 -
41_GLU ASP 8.3kJPN
chr22:41536201 		-
- 0.0002 -
64_TYR PHE VAR_072915 -
Disease - Rubinstein-Taybi syndrome 1 (RSTS1) [MIM:180849]
83_ARG TER ClinVar
chr22:41537115 		rs137853039
Pathogenic - Rubinstein-Taybi syndrome 2 [MedGen:C3150941,OMIM:613684,Orphanet:ORPHA353284]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.