PDB ID 2JKR     CHAIN S
Protein name AP-2 COMPLEX SUBUNIT SIGMA-1
Uniprot Accession P62743
The number of similar proteins 6
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2JKR (CHAIN: S)
1 P84092   P17427  
2 P63010   Q66HM2  
3 Q66HM2   Q90VU7  
4 P84092   P63010   Q66HM2  

Downdload

Format:

Molecule viewer

#binding
partners
  2
  1
  0

Sequence information

1   MIRFILIQNR   AGKTRLAKWY   MQFDDDEKQK   LIEEVHAVVT   VRDAKHTNFV   50
51   EFRNFKIIYR   RYAGLYFCIC   VDVNDNNLAY   LEAIHNFVEV   LNEYFHNVCE   100
101   LDLVFNFYKV   YTVVDEMFLA   GEIRETSQTK   VLKQLLMLQS   LE   150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
15_ARG CYS ClinVar
chr19:47349360
rs397514498
Pathogenic - Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]
15_ARG LEU ClinVar
chr19:47349359
rs397514499
Pathogenic - Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]
15_ARG HIS ClinVar
chr19:47349359
rs397514499
Pathogenic - Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]; not provided [MedGen:CN517202]
44_ALA THR 4.7kJPN
chr19:47349273
rs539480372
- 0.0001 -
77_ASN HIS 4.7kJPN
chr19:47342760
-
- 0.0001 -
129_THR MET 4.7kJPN
chr19:47341747
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.