PiSITE

PDB ID	2JKR	CHAIN	S
Protein name	AP-2 COMPLEX SUBUNIT SIGMA-1
Uniprot Accession	P62743
The number of similar proteins	6
The number of binding states	4
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2JKR (CHAIN: S)
1	P84092 P17427
2	P63010 Q66HM2
3	Q66HM2 Q90VU7
4	P84092 P63010 Q66HM2

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Molecule viewer

Only interaction residues

#binding
partners

	2
	1
	0

Sequence information

1

MIRFILIQNR

AGKTRLAKWY

MQFDDDEKQK

LIEEVHAVVT

VRDAKHTNFV

50

51

EFRNFKIIYR

RYAGLYFCIC

VDVNDNNLAY

LEAIHNFVEV

LNEYFHNVCE

100

101

LDLVFNFYKV

YTVVDEMFLA

GEIRETSQTK

VLKQLLMLQS

LE

150

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
	15_ARG	CYS	ClinVar chr19:47349360	rs397514498	Pathogenic	-	Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]
	15_ARG	LEU	ClinVar chr19:47349359	rs397514499	Pathogenic	-	Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]
	15_ARG	HIS	ClinVar chr19:47349359	rs397514499	Pathogenic	-	Hypocalciuric hypercalcemia, familial, type III [MedGen:C1833372,OMIM:600740,Orphanet:ORPHA101050]; not provided [MedGen:CN517202]
	44_ALA	THR	8.3kJPN chr19:47349273	rs539480372	-	0.0001	-
	77_ASN	HIS	8.3kJPN chr19:47342760	-	-	0.0001	-
	129_THR	MET	8.3kJPN chr19:47341747	-	-	0.0001	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364