PDB ID 2JJV     CHAIN A
Protein name SIGNAL-REGULATORY PROTEIN BETA 1.
Uniprot Accession Q5TFQ8
The number of similar proteins 8
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2JJV (CHAIN: A)
1 Monomeric state
2 Q08722  
3 P78324  
4 6BIT   6BIT  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   EEELQVIQPD   KSISVAAGES   ATLHCTVTSL   IPVGPIQWFR   GAGPGRELIY   50
51   NQKEGHFPRV   TTVSDLTKRN   NMDFSIRISN   ITPADAGTYY   CVKFRKGSPD   100
101   HVEFKSGAGT   ELSVRAKPST   RHHHHHH       150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
13_ILE VAL gnomAD
chr20:1592312
rs72484087
- 0.376733 -
13_ILE VAL 8.3kJPN
chr20:1592312
rs72484087
- 0.6712 -
14_LEU SER gnomAD
chr20:1895796
rs143735290
- 0.0599336 -
14_LEU SER 8.3kJPN
chr20:1895796
rs143735290
- 0.6253 -
20_THR SER gnomAD
chr20:1895813
rs17855609
- 0.0448665 -
20_SER TRP 8.3kJPN
chr20:1559271
rs200657161
- 0.0011 -
20_THR SER 8.3kJPN
chr20:1895813
rs17855609
- 0.6261 -
22_THR ILE VAR_059411 rs1135196
Polymorphism - -
22_THR ILE gnomAD
chr20:1592284
rs1135196
- 0.463184 -
22_THR ILE gnomAD
chr20:1895820
rs17855610
- 0.0628446 -
22_THR ILE 8.3kJPN
chr20:1592284
rs1135196
- - -
22_THR ILE 8.3kJPN
chr20:1895820
rs17855610
- - -
24_ARG HIS gnomAD
chr20:1559259
rs2746603
- 0.0699548 -
24_ARG CYS gnomAD
chr20:1559260
rs143134459
- 0.000197796 -
24_ARG HIS gnomAD
chr20:1895826
rs17855611
- 0.0701003 -
24_ARG HIS 8.3kJPN
chr20:1559259
rs2746603
- 0.0001 -
24_ARG CYS 8.3kJPN
chr20:1895825
rs758642581
- 0.0001 -
24_ARG HIS 8.3kJPN
chr20:1895826
rs17855611
- 0.6265 -
26_THR ILE gnomAD
chr20:1629967
rs143978848
- 0.000298325 -
27_ALA VAL gnomAD
chr20:1895835
rs17855612
- 0.0780698 -
27_ALA VAL 8.3kJPN
chr20:1895835
rs17855612
- 0.6275 -
31_ILE VAL 8.3kJPN
chr20:1592258
-
- 0.0001 -
32_PRO ALA gnomAD
chr20:1592255
rs191373314
- 0.000897313 -
33_VAL LEU gnomAD
chr20:1559233
rs41275424
- 0.00880613 -
33_VAL MET 8.3kJPN
chr20:1629947
rs138452343
- 0.0001 -
35_PRO ALA 8.3kJPN
chr20:1629941
rs200917950
- 0.0004 -
36_VAL ILE gnomAD
chr20:1629938
rs62641738
- 0.000214761 -
36_VAL ILE 8.3kJPN
chr20:1629938
rs62641738
- 0.0002 -
38_TRP LEU gnomAD
chr20:1629931
rs143474967
- 0.000266467 -
42_ALA GLY 8.3kJPN
chr20:1895880
rs143351148
- 0.0001 -
43_GLY ALA 8.3kJPN
chr20:1559202
rs762669905
- 0.0005 -
45_GLY ALA gnomAD
chr20:1592215
rs41289057
- 0.26699 -
45_GLY ALA gnomAD
chr20:1895889
rs1057114
- 0.347307 -
45_GLY ALA 8.3kJPN
chr20:1592215
rs41289057
- 0.6674 -
45_GLY ALA 8.3kJPN
chr20:1895889
rs1057114
- 0.6349 -
47_GLU ASP 8.3kJPN
chr20:1592208
-
- 0.0001 -
49_ILE PHE gnomAD
chr20:1559185
rs145222149
- 0.000843225 -
59_ARG TRP gnomAD
chr20:1559155
rs62641724
- 0.000415534 -
59_ARG TRP gnomAD
chr20:1592174
rs755774584
- 0.000206136 -
59_ARG TRP 8.3kJPN
chr20:1592174
rs755774584
- 0.0001 -
61_THR LYS 8.3kJPN
chr20:1629862
-
- 0.0001 -
65_GLU ASP gnomAD
chr20:1559135
rs145689140
- 0.00263842 -
65_ASP GLU gnomAD
chr20:1592154
rs200203262
- 0.000101353 -
65_GLU ASP 8.3kJPN
chr20:1559135
rs145689140
- 0.0001 -
65_ASP GLU 8.3kJPN
chr20:1592154
rs200203262
- 0.0018 -
65_ASP VAL 8.3kJPN
chr20:1592155
rs759284621
- 0.0006 -
66_LEU PRO 8.3kJPN
chr20:1592152
rs201646968
- 0.0014 -
70_ASN LYS gnomAD
chr20:1592139
rs149722469
- 0.105474 -
70_ASN ASP gnomAD
chr20:1592141
rs141518677
- 0.103716 -
70_ASN ASP gnomAD
chr20:1895963
rs17855613
- 0.303015 -
70_ASN LYS gnomAD
chr20:1895965
rs17855614
- 0.29706 -
70_ASN LYS 8.3kJPN
chr20:1592139
rs149722469
- 0.3875 -
70_ASN ASP 8.3kJPN
chr20:1592141
rs141518677
- 0.3878 -
70_ASN ASP 8.3kJPN
chr20:1895963
rs17855613
- 0.6403 -
70_ASN LYS 8.3kJPN
chr20:1895965
rs17855614
- 0.6403 -
77_SER ARG gnomAD
chr20:1559101
rs41275422
- 0.235934 -
77_ARG SER gnomAD
chr20:1592120
rs1135201
- 0.100228 -
77_ARG SER gnomAD
chr20:1895984
rs17855615
- 0.313565 -
77_SER ARG 8.3kJPN
chr20:1559101
rs41275422
- 0.5501 -
77_ARG SER 8.3kJPN
chr20:1592120
rs1135201
- 0.4104 -
77_ARG SER 8.3kJPN
chr20:1895984
rs17855615
- 0.6404 -
79_SER GLY gnomAD
chr20:1592114
rs1135202
- 0.000703169 -
79_GLY SER gnomAD
chr20:1895990
rs17855616
- 0.318946 -
79_SER GLY 8.3kJPN
chr20:1592114
rs1135202
- 0.0004 -
79_GLY SER 8.3kJPN
chr20:1895990
rs17855616
- 0.6496 -
80_SER ASN gnomAD
chr20:1629805
rs62641735
- 0.00109359 -
81_ILE VAL 8.3kJPN
chr20:1895996
-
- 0.0001 -
82_THR ILE 8.3kJPN
chr20:1629799
-
- 0.0001 -
83_PRO SER 8.3kJPN
chr20:1592102
-
- 0.0001 -
83_PRO SER 8.3kJPN
chr20:1896002
-
- 0.0001 -
87_GLY SER 8.3kJPN
chr20:1896014
rs377556462
- 0.0001 -
95_ARG GLN gnomAD
chr20:1559046
rs145977289
- 0.00026655 -
95_ARG GLN 8.3kJPN
chr20:1559046
rs145977289
- 0.0001 -
95_ARG GLN 8.3kJPN
chr20:1896039
rs767136065
- 0.0001 -
100_ASP GLU 8.3kJPN
chr20:1559030
-
- 0.0002 -
100_ASP ASN 8.3kJPN
chr20:1592051
-
- 0.0009 -
101_HIS ASP gnomAD
chr20:1592048
rs45545343
- 0.00284327 -
102_VAL MET gnomAD
chr20:1896059
rs115287948
- 0.286949 -
102_VAL ALA gnomAD
chr20:1896060
rs114499682
- 0.292307 -
102_VAL MET 8.3kJPN
chr20:1896059
rs115287948
- 0.6411 -
102_VAL ALA 8.3kJPN
chr20:1896060
rs114499682
- 0.6411 -
115_ARG CYS gnomAD
chr20:1558987
rs368470461
- 0.000125293 -
115_ARG HIS 8.3kJPN
chr20:1558986
rs201638914
- 0.0002 -
115_GLY VAL 8.3kJPN
chr20:1629700
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.