PDB ID 2JJV     CHAIN A
Protein name SIGNAL-REGULATORY PROTEIN BETA 1.
Uniprot Accession Q5TFQ8
The number of similar proteins 8
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2JJV (CHAIN: A)
1 Monomeric state
2 Q08722  
3 P78324  
4 6BIT   6BIT  

Downdload

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Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   EEELQVIQPD   KSISVAAGES   ATLHCTVTSL   IPVGPIQWFR   GAGPGRELIY   50
51   NQKEGHFPRV   TTVSDLTKRN   NMDFSIRISN   ITPADAGTYY   CVKFRKGSPD   100
101   HVEFKSGAGT   ELSVRAKPST   RHHHHHH       150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
13_ILE VAL 4.7kJPN
chr20:1592312
rs72484087
- 0.6387 -
14_LEU SER 4.7kJPN
chr20:1895796
rs143735290
- 0.6135 -
20_SER TRP 4.7kJPN
chr20:1559271
rs200657161
- 0.0012 -
20_THR SER 4.7kJPN
chr20:1895813
rs17855609
- 0.616 -
20_THR LYS 4.7kJPN
chr20:1895814
-
- 0.0002 -
22_THR ILE VAR_059411 rs1135196
Polymorphism - -
22_THR ILE 4.7kJPN
chr20:1592284
rs1135196
- 0.647 -
22_THR ILE 4.7kJPN
chr20:1895820
rs17855610
- 0.6147 -
24_ARG CYS 4.7kJPN
chr20:1895825
rs758642581
- 0.0001 -
24_ARG HIS 4.7kJPN
chr20:1895826
rs17855611
- 0.6166 -
27_ALA VAL 4.7kJPN
chr20:1895835
rs17855612
- 0.6186 -
31_ILE VAL 4.7kJPN
chr20:1592258
-
- 0.0001 -
35_PRO ALA 4.7kJPN
chr20:1629941
rs200917950
- 0.0005 -
36_VAL ILE 4.7kJPN
chr20:1629938
rs62641738
- 0.0002 -
43_GLY ALA 4.7kJPN
chr20:1559202
rs762669905
- 0.0004 -
45_GLY ALA 4.7kJPN
chr20:1592215
rs41289057
- 0.6408 -
45_GLY ALA 4.7kJPN
chr20:1895889
rs1057114
- 0.6287 -
47_GLU ASP 4.7kJPN
chr20:1592208
-
- 0.0002 -
59_ARG TRP 4.7kJPN
chr20:1592174
rs755774584
- 0.0001 -
61_THR LYS 4.7kJPN
chr20:1629862
-
- 0.0001 -
65_GLU ASP 4.7kJPN
chr20:1559135
rs145689140
- 0.0001 -
65_ASP VAL 4.7kJPN
chr20:1592155
rs759284621
- 0.0007 -
70_ASN LYS 4.7kJPN
chr20:1592139
rs149722469
- 0.282 -
70_ASN ASP 4.7kJPN
chr20:1592141
rs141518677
- 0.2825 -
70_ASN ASP 4.7kJPN
chr20:1895963
rs17855613
- 0.6354 -
70_ASN LYS 4.7kJPN
chr20:1895965
rs17855614
- 0.6354 -
77_SER ARG 4.7kJPN
chr20:1559101
rs41275422
- 0.551 -
77_ARG SER 4.7kJPN
chr20:1592120
rs1135201
- 0.2818 -
77_ARG SER 4.7kJPN
chr20:1895984
rs17855615
- 0.6357 -
79_SER GLY 4.7kJPN
chr20:1592114
rs1135202
- 0.0007 -
79_GLY SER 4.7kJPN
chr20:1895990
rs17855616
- 0.6446 -
81_ILE VAL 4.7kJPN
chr20:1895996
-
- 0.0001 -
83_PRO SER 4.7kJPN
chr20:1592102
-
- 0.0002 -
83_PRO SER 4.7kJPN
chr20:1896002
-
- 0.0001 -
95_ARG GLN 4.7kJPN
chr20:1559046
rs145977289
- 0.0001 -
95_ARG GLN 4.7kJPN
chr20:1896039
rs767136065
- 0.0001 -
100_ASP GLU 4.7kJPN
chr20:1559030
-
- 0.0001 -
100_ASP ASN 4.7kJPN
chr20:1592051
-
- 0.0015 -
102_VAL MET 4.7kJPN
chr20:1896059
rs115287948
- 0.6364 -
102_VAL ALA 4.7kJPN
chr20:1896060
rs114499682
- 0.6364 -
115_ARG HIS 4.7kJPN
chr20:1558986
rs201638914
- 0.0001 -
115_GLY VAL 4.7kJPN
chr20:1629700
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.