PDB ID 2IAE     CHAIN B
Protein name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Uniprot Accession Q13362
The number of similar proteins 10
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2IAE (CHAIN: B)
1 P67775   Q96DH3  
2 Monomeric state
3 O60566  
4 Q5FBB7   P67775   Q76MZ3  

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Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   IRDVPPADQE   KLFIQKLRQC   CVLFDFVSDP   LSDLKWKEVK   RAALSEMVEY   50
51   ITHNRNVITE   PIYPEVVHMF   AVNMFRTLPP   SSNPTGAEFD   PEEDEPTLEA   100
101   AWPHLQLVYE   FFLRFLESPD   FQPNIAKKYI   DQKFVLQLLE   LFDSEDPRER   150
151   DFLKTTLHRI   YGKFLGLRAY   IRKQINNIFY   RFIYETEHHN   GIAELLEILG   200
201   SIINGFALPL   KEEHKIFLLK   VLLPLHKVKS   LSVYHPQLAY   CVVQFLEKDS   250
251   TLTEPVVMAL   LKYWPKTHSP   KEVMFLNELE   EILDVIEPSE   FVKIMEPLFR   300
301   QLAKCVSSPH   FQVAERALYY   WNNEYIMSLI   SDNAAKILPI   MFPSLYRNSK   350
351   THWNKTIHGL   IYNALKLFME   MNQKLFDDCT   QQFKAEKLKE   KLKMKEREEA   400
401   WVKIENL           450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
31_ARG THR 8.3kJPN
chr14:102285420 		-
- 0.0001 -
51_VAL ILE 8.3kJPN
chr14:102323079 		rs114821166
- 0.0001 -
74_ASN ASP 8.3kJPN
chr6:42974774 		-
- 0.0001 -
121_GLU LYS ClinVar
chr6:42975000 		rs863225081
Pathogenic - not provided [MedGen:CN517202]
121_GLU GLN 8.3kJPN
chr6:42975000 		-
- 0.0001 -
122_GLU LYS ClinVar
chr6:42975003 		rs863225082
Pathogenic/Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
124_GLU LYS ClinVar
chr6:42975009 		rs863225079
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
125_PRO ARG ClinVar
chr6:42975013 		rs876657383
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
131_TRP ARG ClinVar
chr6:42975030 		rs869320691
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]
131_TRP ARG ClinVar
chr6:42975030 		rs869320691
Pathogenic - not provided [MedGen:CN517202]
133_HIS GLN 8.3kJPN
chr6:42975038 		-
- 0.0001 -
155_ALA VAL 8.3kJPN
chr14:102349652 		rs748009220
- 0.0002 -
175_ASP VAL ClinVar
chr6:42975698 		rs1064794719
Likely pathogenic - not provided [MedGen:CN517202]
261_SER ASN 8.3kJPN
chr14:102359429 		-
- 0.0001 -
263_TYR CYS 8.3kJPN
chr6:42976203 		-
- 0.0001 -
272_VAL MET 8.3kJPN
chr14:102360859 		-
- 0.0001 -
325_GLU GLY 8.3kJPN
chr14:102368177 		-
- 0.0001 -
344_GLU LYS ClinVar
chr6:42977066 		rs863225080
Pathogenic/Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; not provided [MedGen:CN517202]
359_ILE VAL 8.3kJPN
chr6:42977111 		rs755300874
- 0.0001 -
370_MET ILE 8.3kJPN
chr14:102372825 		-
- 0.0001 -
386_ILE VAL 8.3kJPN
chr14:102375930 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.