PDB ID 2IAE     CHAIN B
Protein name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Uniprot Accession Q13362
The number of similar proteins 10
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2IAE (CHAIN: B)
1 P67775   Q96DH3  
2 Monomeric state
3 O60566  
4 Q5FBB7   P67775   Q76MZ3  

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Molecule viewer

#binding
partners
  1
  0

Sequence information

1   IRDVPPADQE   KLFIQKLRQC   CVLFDFVSDP   LSDLKWKEVK   RAALSEMVEY   50
51   ITHNRNVITE   PIYPEVVHMF   AVNMFRTLPP   SSNPTGAEFD   PEEDEPTLEA   100
101   AWPHLQLVYE   FFLRFLESPD   FQPNIAKKYI   DQKFVLQLLE   LFDSEDPRER   150
151   DFLKTTLHRI   YGKFLGLRAY   IRKQINNIFY   RFIYETEHHN   GIAELLEILG   200
201   SIINGFALPL   KEEHKIFLLK   VLLPLHKVKS   LSVYHPQLAY   CVVQFLEKDS   250
251   TLTEPVVMAL   LKYWPKTHSP   KEVMFLNELE   EILDVIEPSE   FVKIMEPLFR   300
301   QLAKCVSSPH   FQVAERALYY   WNNEYIMSLI   SDNAAKILPI   MFPSLYRNSK   350
351   THWNKTIHGL   IYNALKLFME   MNQKLFDDCT   QQFKAEKLKE   KLKMKEREEA   400
401   WVKIENL           450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
31_ARG THR 4.7kJPN
chr14:102285420
-
- 0.0001 -
121_GLU LYS ClinVar
chr6:42975000
rs863225081
Pathogenic - not provided [MedGen:CN517202]
122_GLU LYS ClinVar
chr6:42975003
rs863225082
Pathogenic/Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
124_GLU LYS ClinVar
chr6:42975009
rs863225079
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
125_PRO ARG ClinVar
chr6:42975013
rs876657383
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
131_TRP ARG ClinVar
chr6:42975030
rs869320691
Pathogenic - Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]
131_TRP ARG ClinVar
chr6:42975030
rs869320691
Pathogenic - not provided [MedGen:CN517202]
133_HIS GLN 4.7kJPN
chr6:42975038
-
- 0.0001 -
155_ALA VAL 4.7kJPN
chr14:102349652
rs748009220
- 0.0001 -
175_ASP VAL ClinVar
chr6:42975698
rs1064794719
Likely pathogenic - not provided [MedGen:CN517202]
263_TYR CYS 4.7kJPN
chr6:42976203
-
- 0.0001 -
272_VAL MET 4.7kJPN
chr14:102360859
-
- 0.0001 -
305_LEU PHE 4.7kJPN
chr6:42976857
-
- 0.0001 -
321_SER GLY 4.7kJPN
chr6:42976903
rs778608571
- 0.0001 -
321_SER ILE 4.7kJPN
chr6:42976904
-
- 0.0001 -
324_MET LEU 4.7kJPN
chr6:42976912
-
- 0.0001 -
324_MET LYS 4.7kJPN
chr6:42976913
-
- 0.0001 -
341_GLN TER 4.7kJPN
chr6:42976963
-
- 0.0001 -
344_GLU LYS ClinVar
chr6:42977066
rs863225080
Pathogenic/Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; not provided [MedGen:CN517202]
370_MET ILE 4.7kJPN
chr14:102372825
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.