PDB ID 2H4M     CHAIN A
Protein name Transportin-1
Uniprot Accession Q92973
The number of similar proteins 19
The number of binding states 8
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2H4M (CHAIN: A)
1 Q92973   P09651  
2 Monomeric state
3 P35637  
4 Q9UBU9  
5 Q8TBR3  
6 P32505  
7 P52272  
8 P62826  

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#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MEYEWKPDEQ   GLQQILQLLK   ESQSPDTTIQ   RTVQQKLEQL   NQYPDFNNYL   50
51   IFVLTKLKSE   DEPTRSLSGL   ILKNNVKAHF   QNFPNGVTDF   IKSECLNNIG   100
101   DSSPLIRATV   GILITTIASK   GELQNWPDLL   PKLCSLLDSE   DYNTCEGAFG   150
151   ALQKICEDSA   EILDSDVLDR   PLNIMIPKFL   QFFKHSSPKI   RSHAVACVNQ   200
201   FIISRTQALM   LHIDSFIENL   FALAGDEEPE   VRKNVCRALV   MLLEVRMDRL   250
251   LPHMHNIVEY   MLQRTQDQDE   NVALEACEFW   LTLAEQPICK   DVLVRHLPKL   300
301   IPVLVNGMKY   SDIDIILLKG   DVEEDETIPD   SEQDIGGSGG   SGDTISDWNL   350
351   RKCSAAALDV   LANVYRDELL   PHILPLLKEL   LFHHEWVVKE   SGILVLGAIA   400
401   EGCMQGMIPY   LPELIPHLIQ   CLSDKKALVR   SITCWTLSRY   AHWVVSQPPD   450
451   TYLKPLMTEL   LKRILDSNKR   VQEAACSAFA   TLEEEACTEL   VPYLAYILDT   500
501   LVFAFSKYQH   KNLLILYDAI   GTLADSVGHH   LNKPEYIQML   MPPLIQKWNM   550
551   LKDEDKDLFP   LLECLSSVAT   ALQSGFLPYC   EPVYQRCVNL   VQKTLAQAML   600
601   NNAQPDQYEA   PDKDFMIVAL   DLLSGLAEGL   GGNIEQLVAR   SNILTLMYQC   650
651   MQDKMPEVRQ   SSFALLGDLT   KACFQHVKPC   IADFMPILGT   NLNPEFISVC   700
701   NNATWAIGEI   SIQMGIEMQP   YIPMVLHQLV   EIINRPNTPK   TLLENTAITI   750
751   GRLGYVCPQE   VAPMLQQFIR   PWCTSLRNIR   DNEEKDSAFR   GICTMISVNP   800
801   SGVIQDFIFF   CDAVASWINP   KDDLRDMFCK   ILHGFKNQVG   DENWRRFSDQ   850
851   FPLPLKERLA   AFYGV         900

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
99_ILE VAL 4.7kJPN
chr5:72151714
-
- 0.0001 -
166_ASP GLU 4.7kJPN
chr19:12826293
-
- 0.0001 -
196_ALA THR 4.7kJPN
chr19:12826125
rs1295567219
- 0.0001 -
249_ARG SER 4.7kJPN
chr19:12825891
-
- 0.0001 -
268_HIS PRO 4.7kJPN
chr19:12825728
-
- 0.0001 -
285_GLU ASP 4.7kJPN
chr5:72173132
rs74481451
- 0.0006 -
298_PRO SER 4.7kJPN
chr5:72173169
rs200584417
- 0.0042 -
424_ILE VAL 4.7kJPN
chr19:12821444
-
- 0.0001 -
445_GLN ARG 4.7kJPN
chr5:72183959
rs564000608
- 0.0001 -
492_GLY SER 4.7kJPN
chr19:12817415
-
- 0.0002 -
558_LYS GLU 4.7kJPN
chr5:72185779
-
- 0.0001 -
632_GLN ARG 4.7kJPN
chr5:72189226
-
- 0.0001 -
705_CYS SER 4.7kJPN
chr5:72189525
-
- 0.0001 -
821_ILE THR 4.7kJPN
chr5:72196872
rs201701131
- 0.0001 -
839_VAL ILE 4.7kJPN
chr5:72199560
rs113153605
- 0.0001 -
854_TYR PHE 4.7kJPN
chr19:12812416
-
- 0.0001 -
878_PRO LEU 4.7kJPN
chr19:12812200
rs201711242
- 0.0003 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.