PiSITE

PDB ID	2G47	CHAIN	C
Protein name	amyloid protein beta A4
PDB	2G47
The number of similar proteins	218
The number of binding states	17
The number of binding partners	7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2G47 (CHAIN: C)
1	P14735
2	Monomeric state
3	P05067
4	P80188
5	Q5JRX3
6	P05067 P05067
7	2OTK 2OTK
8	3IFN 3IFN
9	P05067 P05067 P05067
10	P05067 P05067 P05067 P05067
11	P05067 P05067 P05067 P05067 P05067
12	P05067 P05067 P05067 P05067 P05067 P05067
13	P05067 P05067 P05067 P05067 P05067 P05067 P05067
14	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
15	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
16	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
17	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067

Downdload

Molecule viewer

Only interaction residues

#binding
partners

	5
	4
	3
	2
	1
	0

Sequence information

1

DAEFRHDSGY

EVHHQKLVFF

AEDVGSNKGA

IIGLMVGGVV

50

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
	2_ALA	VAL	ClinVar chr21:27269931	rs193922916	Pathogenic	-	Alzheimer disease [Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]
	2_ALA	THR	gnomAD chr21:27269932	rs63750847	-	0.000445519	-
	16_LYS	ASN	ClinVar chr21:27269888	-	Likely pathogenic	-	Cerebral amyloid angiopathy, APP-related [MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458]; Alzheimer disease type 1 [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300]
	20_PHE	LEU	8.3kJPN chr21:27264174	-	-	0.0001	-
	21_ALA	GLY	ClinVar chr21:27264170	rs63750671	Pathogenic	-	Alzheimer disease type 1\|Alzheimer disease\|ABetaA21G amyloidosis\|not provided [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020\|MONDO:MONDO:0017948,MedGen:C3888307,Orphanet:324718\|MedGen:C3661900]
	22_GLU	GLN	ClinVar chr21:27264168	rs63750579	Pathogenic	-	ABeta amyloidosis, dutch type\|Cerebral amyloid angiopathy, APP-related\|Alzheimer disease [MONDO:MONDO:0015033,MedGen:C2931672,Orphanet:100006\|MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]
	22_GLU	GLY	ClinVar chr21:27264167	rs63751039	Pathogenic	-	Alzheimer disease type 1\|ABeta amyloidosis, Arctic type\|Alzheimer disease\|not provided [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300\|MONDO:MONDO:0017949,MedGen:C2751494,Orphanet:324723\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020\|MedGen:C3661900]
	22_GLU	LYS	ClinVar chr21:27264168	rs63750579	Pathogenic	-	ABeta amyloidosis, Italian type\|not provided [MONDO:MONDO:0017947,MedGen:C3888308,Orphanet:324713\|MedGen:CN517202]
	23_ASP	ASN	ClinVar chr21:27264165	rs63749810	Pathogenic	-	ABeta amyloidosis, Iowa type\|not provided\|Alzheimer disease [MONDO:MONDO:0017946,MedGen:C3888309,Orphanet:324708\|MedGen:C3661900\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364