PDB ID 2EWY     CHAIN A
Protein name Beta-secretase 2
Uniprot Accession Q9Y5Z0
The number of similar proteins 13
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2EWY (CHAIN: A)
1 Monomeric state
2 3ZKQ  
3 3ZL7  
4 3ZKN   3ZKN  
5 3ZKX   3ZKX  
6 Q9Y5Z0   3ZLQ  

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Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   LAMVDNLQGD   SGRGYYLEML   IGTPPQKLQI   LVDTGSSNFA   VAGTPHSYID   50
51   TYFDTERSST   YRSKGFDVTV   KYTQGSWTGF   VGEDLVTIPK   GFNTSFLVNI   100
101   ATIFESENFF   LPGIKWNGIL   GLAYATLAKP   SSSLETFFDS   LVTQANIPNV   150
151   FSMQMCGAGL   PVAGSGTNGG   SLVLGGIEPS   LYKGDIWYTP   IKEEWYYQIE   200
201   ILKLEIGGQS   LNLDCREYNA   DKAIVDSGTT   LLRLPQKVFD   AVVEAVARAS   250
251   LIPEFSDGFW   TGSQLACWTN   SETPWSYFPK   ISIYLRDENS   SRSFRITILP   300
301   QLYIQPMMGA   GLNYECYRFG   ISPSTNALVI   GATVMEGFYV   IFDRAQKRVG   350
351   FAASPCAEIA   GAAVSEISGP   FSTEDVASNC   VPA     400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
40_PRO SER 4.7kJPN
chr21:42540494
rs780184860
- 0.0002 -
77_ARG CYS 4.7kJPN
chr21:42609453
rs766433535
- 0.0001 -
96_VAL ILE 4.7kJPN
chr21:42609510
rs781596817
- 0.0004 -
101_VAL ILE 4.7kJPN
chr21:42609525
rs778102614
- 0.0001 -
207_LYS ARG 4.7kJPN
chr21:42615361
-
- 0.0001 -
252_LYS THR 4.7kJPN
chr21:42617947
-
- 0.0001 -
289_PRO ARG 4.7kJPN
chr21:42622746
rs768959890
- 0.0001 -
290_TRP SER 4.7kJPN
chr21:42622749
rs781629087
- 0.0002 -
310_ARG CYS 4.7kJPN
chr21:42622808
rs139556900
- 0.0001 -
355_VAL ILE 4.7kJPN
chr21:42629199
rs146761165
- 0.0001 -
356_ILE VAL 4.7kJPN
chr21:42629202
rs1418222703
- 0.0001 -
356_ILE MET 4.7kJPN
chr21:42629204
-
- 0.0001 -
359_ARG SER 4.7kJPN
chr21:42629213
-
- 0.0001 -
368_ALA VAL 4.7kJPN
chr21:42629239
rs1322689391
- 0.0001 -
370_PRO THR 4.7kJPN
chr21:42629244
-
- 0.0001 -
371_CYS PHE 4.7kJPN
chr21:42629248
rs1206170769
- 0.0001 -
385_PRO LEU 4.7kJPN
chr21:42647334
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.