PDB ID 2A73     CHAIN B
Protein name Complement C3
Uniprot Accession P01024
The number of similar proteins 18
The number of binding states 9
The number of binding partners 10

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer

#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   VQLTEKRMDK   VGKYPKELRK   CCEDGMRENP   MRFSCQRRTR   FISLGEACKK   50
51   VFLDCCNYIT   ELRRQHARAS   HLGLARSNLD   EDIIAEENIV   SRSEFPESWL   100
101   WNVEDLKEPP   KNGISTKLMN   IFLKDSITTW   EILAVSMSDK   KGICVADPFE   150
151   VTVMQDFFID   LRLPYSVVRN   EQVEIRAVLY   NYRQNQELKV   RVELLHNPAF   200
201   CSLATTKRRH   QQTVTIPPKS   SLSVPYVIVP   LKTGLQEVEV   KAAVYHHFIS   250
251   DGVRKSLKVV   PEGIRMNKTV   AVRTLDPERL   GREGVQKEDI   PPADLSDQVP   300
301   DTESETRILL   QGTPVAQMTE   DAVDAERLKH   LIVTPSGCGE   QNMIGMTPTV   350
351   IAVHYLDETE   QWEKFGLEKR   QGALELIKKG   YTQQLAFRQP   SSAFAAFVKR   400
401   APSTWLTAYV   VKVFSLAVNL   IAIDSQVLCG   AVKWLILEKQ   KPDGVFQEDA   450
451   PVIHQEMIGG   LRNNNEKDMA   LTAFVLISLQ   EAKDICEEQV   NSLPGSITKA   500
501   GDFLEANYMN   LQRSYTVAIA   GYALAQMGRL   KGPLLNKFLT   TAKDKNRWED   550
551   PGKQLYNVEA   TSYALLALLQ   LKDFDFVPPV   VRWLNEQRYY   GGGYGSTQAT   600
601   FMVFQALAQY   QKDAPDHQEL   NLDVSLQLPS   RSSKITHRIH   WESASLLRSE   650
651   ETKENEGFTV   TAEGKGQGTL   SVVTMYHAKA   KDQLTCNKFD   LKVTIKPAPE   700
701   TEKRPQDAKN   TMILEICTRY   RGDQDATMSI   LDISMMTGFA   PDTDDLKQLA   750
751   NGVDRYISKY   ELDKAFSDRN   TLIIYLDKVS   HSEDDCLAFK   VHQYFNVELI   800
801   QPGAVKVYAY   YNLEESCTRF   YHPEKEDGKL   NKLCRDELCR   CAEENCFIQK   850
851   SDDKVTLEER   LDKACEPGVD   YVYKTRLVKV   QLSNDFDEYI   MAIEQTIKSG   900
901   SDEVQVGQQR   TFISPIKCRE   ALKLEEKKHY   LMWGLSSDFW   GEKPNLSYII   950
951   GKDTWVEHWP   EEDECQDEEN   QKQCQDLGAF   TESMVVFGCP   N   1000

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
665_PRO THR 4.7kJPN
chr19:6707273
-
- 0.0001 -
690_ARG HIS 4.7kJPN
chr19:6707197
rs773113880
- 0.0003 -
690_ARG CYS 4.7kJPN
chr19:6707198
rs763061857
- 0.0001 -
713_ARG TRP VAR_063215 rs117793540
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
714_ARG GLN 4.7kJPN
chr19:6707125
rs578116271
- 0.0004 -
718_ARG TRP 4.7kJPN
chr19:6707114
rs945676974
- 0.0002 -
743_SER THR 4.7kJPN
chr19:6702542
-
- 0.0002 -
753_VAL ALA 4.7kJPN
chr19:6702512
-
- 0.0001 -
807_PHE LEU 4.7kJPN
chr19:6697759
-
- 0.0001 -
841_ARG LYS VAR_019206 rs11569472
Polymorphism - -
864_VAL ILE 4.7kJPN
chr19:6697495
rs149395057
- 0.0003 -
868_PRO ARG 4.7kJPN
chr19:6697482
rs753876258
- 0.0001 -
878_ILE MET 4.7kJPN
chr19:6697451
rs763155610
- 0.0021 -
890_VAL LEU 4.7kJPN
chr19:6697417
-
- 0.0001 -
908_LYS ASN 4.7kJPN
chr19:6697361
-
- 0.0002 -
991_GLN HIS 4.7kJPN
chr19:6694557
-
- 0.0001 -
995_GLY CYS 4.7kJPN
chr19:6694547
-
- 0.0003 -
1020_ARG LEU VAR_063655 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1072_ALA VAL VAR_063216 rs121909584
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1093_ASP ASN VAR_063217 rs121909585
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1122_THR ALA 4.7kJPN
chr19:6690699
-
- 0.0001 -
1136_CYS TRP VAR_063218 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1139_GLN LYS VAR_063219 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1202_GLY ASP VAR_019207 rs11569534
Polymorphism - -
1241_GLY ALA 4.7kJPN
chr19:6686157
-
- 0.0001 -
1249_ALA SER 4.7kJPN
chr19:6685157
-
- 0.0001 -
1281_ARG HIS ClinVar
chr19:6685060
rs775015499
Likely pathogenic - Atypical hemolytic-uremic syndrome 5 [MedGen:C2752037,OMIM:612925,Orphanet:ORPHA93575]
1281_ARG CYS 4.7kJPN
chr19:6685061
rs567359713
- 0.0001 -
1345_ILE THR VAR_019208 rs11569541
Polymorphism - -
1359_LYS ARG 4.7kJPN
chr19:6684429
rs1232402436
- 0.0001 -
1371_ARG GLN 4.7kJPN
chr19:6682235
rs575119407
- 0.0004 -
1371_ARG TRP 4.7kJPN
chr19:6682236
rs148227405
- 0.0002 -
1378_MET VAL 4.7kJPN
chr19:6682215
-
- 0.0001 -
1418_ASP ASN 4.7kJPN
chr19:6681984
rs772034590
- 0.0001 -
1442_HIS ASP VAR_063220 -
Disease - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1473_PRO ALA 4.7kJPN
chr19:6679481
-
- 0.0002 -
1499_GLN ARG VAR_029792 rs7256789
Polymorphism - -
1579_HIS ASN VAR_029793 rs1803225
Polymorphism - -
1582_MET THR 4.7kJPN
chr19:6678202
rs761512303
- 0.0003 -
1597_SER ARG VAR_029326 rs2230210
Polymorphism - -
1604_THR SER 4.7kJPN
chr19:6678008
rs1386293935
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.