PDB ID 1RKC     CHAIN A
Protein name Vinculin
Uniprot Accession P18206
The number of similar proteins 25
The number of binding states 8
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1RKC (CHAIN: A)
1 Monomeric state
2 P18206  
3 32307018  
4 Q7Z5R6  
5 Q8AWI0  
6 P26231  
7 P26231  
8 P26039  

Downdload

Format:

Molecule viewer

#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   HHHHMPVFHT   RTIESILEPV   AQQISHLVIM   HEEGEVDGKA   IPDLTAPVAA   50
51   VQAAVSNLVR   VGKETVQTTE   DQILKRDMPP   AFIKVENACT   KLVQAAQMLQ   100
101   SDPYSVPARD   YLIDGSRGIL   SGTSDLLLTF   DEAEVRKIIR   VCKGILEYLT   150
151   VAEVVETMED   LVTYTKNLGP   GMTKMAKMID   ERQQELTHQE   HRVMLVNSMN   200
201   TVKELLPVLI   SAMKIFVTTK   NSKNQGIEEA   LKNRNFTVEK   MSAEINEIIR   250
251   VLQLTSWDED   AW         300

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
94_MET ILE 4.7kJPN
chr10:75830470
rs774870551
- 0.0001 -
105_ARG TER 4.7kJPN
chr10:75830501
rs397517239
- 0.0001 -
188_ARG GLN 4.7kJPN
chr10:75832551
rs770173689
- 0.0001 -
209_MET LEU 4.7kJPN
chr10:75834503
rs144683137
- 0.0009 -
215_THR ILE 4.7kJPN
chr10:75834522
rs1287472049
- 0.0001 -
230_ARG HIS 4.7kJPN
chr10:75834567
rs749628307
- 0.0001 -
234_VAL LEU VAR_037667 rs17853882
Polymorphism - -
237_MET ILE 4.7kJPN
chr10:75834589
-
- 0.0001 -
238_SER ARG 4.7kJPN
chr10:75834592
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.