PDB ID 1MQ4     CHAIN A
Protein name AURORA-RELATED KINASE 1
Uniprot Accession O14965
The number of similar proteins 159
The number of binding states 11
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1MQ4 (CHAIN: A)
1 Monomeric state
2 5G15  
3 P04198  
4 Q8JJ25  
5 Q9Y6A5  
6 Q9ULW0  
7 O14965  
8 O14965   O14965  
9 O14965   6CPG   6CPG  
10 O14965   Q9ULW0   Q9ULW0  
11 O14965   O14965   O14965  

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Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   GAMGSKRQWA   LEDFEIGRPL   GKGKFGNVYL   AREKQSKFIL   ALKVLFKAQL   50
51   EKAGVEHQLR   REVEIQSHLR   HPNILRLYGY   FHDATRVYLI   LEYAPLGTVY   100
101   RELQKLSKFD   EQRTATYITE   LANALSYCHS   KRVIHRDIKP   ENLLLGSAGE   150
151   LKIADFGWSV   HAPSSRRTTL   CGTLDYLPPE   MIEGRMHDEK   VDLWSLGVLC   200
201   YEFLVGKPPF   EANTYQETYK   RISRVEFTFP   DFVTEGARDL   ISRLLKHNPS   250
251   QRPMLREVLE   HPWITANSSK   PS       300

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
155_SER ARG VAR_041128 -
Unclassified - A colorectal adenocarcinoma sample
174_VAL MET VAR_041129 -
Unclassified - A metastatic melanoma sample
189_ARG TRP 4.7kJPN
chr20:54958042
rs779964295
- 0.0001 -
223_GLN LYS 4.7kJPN
chr20:54956527
rs1217224639
- 0.0006 -
279_VAL ILE 4.7kJPN
chr20:54948483
-
- 0.0002 -
305_MET LYS 4.7kJPN
chr20:54945656
-
- 0.0001 -
309_LYS GLU 4.7kJPN
chr20:54945645
-
- 0.0001 -
343_ARG TRP 4.7kJPN
chr20:54945543
rs774552788
- 0.0001 -
373_MET VAL VAR_041130 rs33923703
Polymorphism - -
373_MET VAL 4.7kJPN
chr20:54945309
rs33923703
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.