PDB ID 1M63     CHAIN A
Protein name SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM
Uniprot Accession Q08209
The number of similar proteins 10
The number of binding states 8
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1M63 (CHAIN: A)
1 P63098   P63098   P62937   P62937  
2 Monomeric state
3 P63098  
4 Q08209   P63098  
5 P63098   O36972  
6 P63099   P62942  
7 P63098   P62937  
8 P63098   P62937   P62937  

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Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MSEPKAIDPK   LSTTDRVVKA   VPFPPSHRLT   AKEVFDNDGK   PRVDILKAHL   50
51   MKEGRLEESV   ALRIITEGAS   ILRQEKNLLD   IDAPVTVCGD   IHGQFFDLMK   100
101   LFEVGGSPAN   TRYLFLGDYV   DRGYFSIECV   LYLWALKILY   PKTLFLLRGN   150
151   HECRHLTEYF   TFKQECKIKY   SERVYDACMD   AFDCLPLAAL   MNQQFLCVHG   200
201   GLSPEINTLD   DIRKLDRFKE   PPAYGPMCDI   LWSDPLEDFG   NEKTQEHFTH   250
251   NTVRGCSYFY   SYPAVCEFLQ   HNNLLSILRA   HEAQDAGYRM   YRKSQTTGFP   300
301   SLITIFSAPN   YLDVYNNKAA   VLKYENNVMN   IRQFNCSPHP   YWLPNFMDVF   350
351   TWSLPFVGEK   VTEMLVNVLN   IC       400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
5_LYS THR 4.7kJPN
chr4:102267940
-
- 0.0002 -
9_PRO THR 4.7kJPN
chr4:102267929
rs746412506
- 0.0002 -
10_PRO LEU 4.7kJPN
chr10:75255592
-
- 0.0001 -
30_THR ALA 4.7kJPN
chr4:102117244
-
- 0.0001 -
66_ASN SER 4.7kJPN
chr8:22332602
-
- 0.0001 -
66_ASN SER 4.7kJPN
chr10:75239137
rs772163544
- 0.0001 -
78_MET VAL 4.7kJPN
chr10:75239102
rs1194657674
- 0.0001 -
92_HIS ARG VAR_080348 -
Unclassified - Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1) [MIM:617711]
92_HIS ARG ClinVar
chr4:102030220
rs1553925558
Pathogenic - EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 [MedGen:C4540199,OMIM:617711]
104_VAL ILE 4.7kJPN
chr4:102030185
-
- 0.0001 -
109_ALA VAL 4.7kJPN
chr10:75238315
-
- 0.0001 -
138_ILE THR 4.7kJPN
chr8:22355542
-
- 0.0001 -
173_ARG CYS 4.7kJPN
chr4:102019649
rs777415869
- 0.0002 -
207_THR SER 4.7kJPN
chr8:22368722
-
- 0.0001 -
224_TYR CYS 4.7kJPN
chr4:102015044
-
- 0.0001 -
242_GLU GLY 4.7kJPN
chr4:102014990
-
- 0.0001 -
263_PRO ARG 4.7kJPN
chr8:22380009
-
- 0.0001 -
281_HIS GLN VAR_080349 -
Unclassified - Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1) [MIM:617711]
281_HIS GLN ClinVar
chr4:102004360
rs199706529
Pathogenic - EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 [MedGen:C4540199,OMIM:617711]
282_GLU LYS VAR_080350 -
Unclassified - Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1) [MIM:617711]
282_GLU LYS ClinVar
chr4:102004359
rs1553923787
Likely pathogenic - EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 [MedGen:C4540199,OMIM:617711]; Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
292_ARG SER 4.7kJPN
chr8:22380183
-
- 0.0001 -
297_THR ILE 4.7kJPN
chr8:22380197
rs912550463
- 0.0004 -
313_ASP GLY 4.7kJPN
chr4:102001706
-
- 0.0001 -
341_TYR CYS 4.7kJPN
chr8:22384971
rs369427673
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.