PDB ID 1KLA     CHAIN A
Protein name TRANSFORMING GROWTH FACTOR-BETA 1
Uniprot Accession P01137
The number of similar proteins 12
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1KLA (CHAIN: A)
1 P01137  
2 P01137   P36897   P36897   P37173  
3 P01137   Q14392   P01137   P01137  
4 P01137   6GFF   Q14392   P01137   P01137  

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Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   ALDTNYCFSS   TEKNCCVRQL   YIDFRKDLGW   KWIHEPKGYH   ANFCLGPCPY   50
51   IWSLDTQYSK   VLALYNQHNP   GASAAPCCVP   QALEPLPIVY   YVGRKPKVEQ   100
101   LSNMIVRSCK   CS         150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
3_ASP HIS 4.7kJPN
chr19:41847807
-
- 0.0001 -
10_SER PHE 4.7kJPN
chr19:41838184
-
- 0.0001 -
21_TYR TER ClinVar
chr19:41838150
rs1057521741
Likely pathogenic - not provided [MedGen:CN517202]
29_GLY SER 4.7kJPN
chr19:41838128
-
- 0.0001 -
75_ALA VAL 4.7kJPN
chr19:41837072
-
- 0.0003 -
109_CYS ARG ClinVar
chr19:41836971
rs1336387628
Pathogenic - Encephalopathy [Human Phenotype Ontology:HP:0001298,MedGen:C1963101]; INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY [MedGen:CN257492,OMIM:618213]; Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome [MedGen:CN744913,Orphanet:ORPHA238569]
110_LYS ASN 4.7kJPN
chr19:41836966
rs943475580
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.