PDB ID 1KLA     CHAIN A
Protein name TRANSFORMING GROWTH FACTOR-BETA 1
Uniprot Accession P01137
The number of similar proteins 12
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1KLA (CHAIN: A)
1 P01137  
2 P01137   P36897   P36897   P37173  
3 P01137   Q14392   P01137   P01137  
4 P01137   6GFF   Q14392   P01137   P01137  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   ALDTNYCFSS   TEKNCCVRQL   YIDFRKDLGW   KWIHEPKGYH   ANFCLGPCPY   50
51   IWSLDTQYSK   VLALYNQHNP   GASAAPCCVP   QALEPLPIVY   YVGRKPKVEQ   100
101   LSNMIVRSCK   CS         150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_ASP HIS 8.3kJPN
chr19:41847807 		-
- 0.0001 -
10_SER PHE 8.3kJPN
chr19:41838184 		-
- 0.0001 -
18_ARG GLN gnomAD
chr19:41838160 		rs200164212
- 0.00041832 -
18_ARG GLN 8.3kJPN
chr19:41838160 		rs200164212
- 0.0001 -
21_TYR TER ClinVar
chr19:41838150 		rs1057521741
Likely pathogenic - not provided [MedGen:CN517202]
29_GLY SER 8.3kJPN
chr19:41838128 		-
- 0.0001 -
59_SER THR gnomAD
chr19:41838037 		rs199699574
- 0.000608805 -
75_ALA VAL 8.3kJPN
chr19:41837072 		-
- 0.0002 -
107_ARG GLY 8.3kJPN
chr19:41836977 		rs981119783
- 0.0001 -
109_CYS ARG VAR_081586 -
LP/P - Inflammatory bowel disease, immunodeficiency, and encephalopathy (IBDIMDE) [MIM:618213]
109_CYS ARG ClinVar
chr19:41836971 		rs1336387628
Likely pathogenic - Encephalopathy [Human Phenotype Ontology:HP:0001298,MedGen:C0085584]; Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome|Inflammatory bowel disease, immunodeficiency, and encephalopathy [MONDO:MONDO:0016542,MedGen:C4749850,Orphanet:238569|MONDO:MONDO:0032601,MedGen:C4748708,OMIM:618213,Orphanet:565788]
110_LYS ASN 8.3kJPN
chr19:41836966 		rs943475580
- 0.0002 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.