PDB ID 1K8K     CHAIN C
Protein name ARP2/3 COMPLEX 41 KDA SUBUNIT
Uniprot Accession Q58CQ2
The number of similar proteins 20
The number of binding states 4
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1K8K (CHAIN: C)
1 Q3SYX9   Q148J6   A7MB62  
2 Q3SYX9   Q148J6  
3 Q3SYX9   Q148J6   Q3MHR7   A7MB62  
4 Q3SYX9   Q148J6   Q3MHR7   A7MB62   Q9ERL7  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MAYHSFLVEP   ISCHAWNKDR   TQIAICPNNH   EVHIYEKSGN   KWVQVHELKE   50
51   HNGQVTGVDW   APDSNRIVTC   GTDRNAYVWT   LKGRTWKPTL   VILRINRAAR   100
101   CVRWAPNEKK   FAVGSGSRVI   SICYFEQEND   WWVCKHIKKP   IRSTVLSLDW   150
151   HPNSVLLAAG   SCDFKCRIFS   AYIKEVEERP   APTPWGSKMP   FGELMFESSS   200
201   SCGWVHGVCF   SANGSRVAWV   SHDSTVCLAD   ADKKMAVATL   ASETLPLLAV   250
251   TFITESSLVA   AGHDCFPVLF   TYDSAAGKLS   FGGRLDVPKQ   SSQRGLTARE   300
301   RFQNLDKKAS   SEGSAAAGAG   LDSLHKNSVS   QISVLSGGKA   KCSQFCTTGM   350
351   DGGMSIWDVR   SLESALKDLK   IV       400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
14_HIS ASP 8.3kJPN
chr7:98983377 		-
- 0.0002 -
17_ASN LYS gnomAD
chr7:98983388 		rs142972568
- 0.000247999 -
20_ARG CYS gnomAD
chr7:98983395 		rs750614736
- 0.000108304 -
33_HIS ARG gnomAD
chr7:98984341 		rs200838883
- 0.00172455 -
37_LYS ASN gnomAD
chr7:98984354 		rs1045012
- 0.0557211 -
37_LYS ASN 8.3kJPN
chr7:98984354 		rs1045012
- 0.0155 -
66_ARG GLY 8.3kJPN
chr7:98985688 		-
- 0.0001 -
77_TYR TER ClinVar
chr7:98985723 		rs116204707
Pathogenic - not provided [MedGen:C3661900]
96_ASN SER gnomAD
chr7:98985779 		rs201019693
- 0.000417777 -
103_ARG HIS 8.3kJPN
chr7:98985800 		rs11556758
- 0.0001 -
104_TRP SER ClinVar
chr7:98985803 		rs2150894118
Likely pathogenic - not provided [MedGen:C3661900]
105_ALA VAL ClinVar
chr7:98985806 		rs1186149065
Pathogenic - Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease [MONDO:MONDO:0060583,MedGen:C4540232,OMIM:617718]
113_VAL MET 8.3kJPN
chr7:98985829 		-
- 0.0001 -
144_THR ILE 8.3kJPN
chr7:98987566 		rs1346643217
- 0.0001 -
145_VAL ILE 8.3kJPN
chr7:98987568 		rs1192417300
- 0.0001 -
149_ASP TYR gnomAD
chr7:98987580 		rs143427534
- 0.000787615 -
167_ARG LEU 8.3kJPN
chr7:98987635 		rs772757150
- 0.0001 -
168_ILE LEU 8.3kJPN
chr7:98988517 		-
- 0.0001 -
180_PRO LEU 8.3kJPN
chr7:98988554 		rs759537436
- 0.0001 -
196_PHE LEU 8.3kJPN
chr7:98988603 		-
- 0.0001 -
208_VAL PHE ClinVar
chr7:98988637 		rs371760619
Pathogenic - Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease [MONDO:MONDO:0060583,MedGen:C4540232,OMIM:617718]
208_VAL ILE 8.3kJPN
chr7:98988637 		rs371760619
- 0.0002 -
216_ARG HIS 8.3kJPN
chr7:98988662 		rs760543643
- 0.0002 -
226_VAL ILE gnomAD
chr7:98988691 		rs756502444
- 0.000255902 -
226_VAL ILE 8.3kJPN
chr7:98988691 		rs756502444
- 0.0002 -
232_ASP ASN gnomAD
chr7:98988709 		rs149569034
- 0.000100397 -
237_VAL ILE 8.3kJPN
chr7:98988802 		rs776539765
- 0.0001 -
238_ALA THR gnomAD
chr7:98988805 		rs147238850
- 0.000135494 -
261_ALA ALA ClinVar
chr7:98988876 		rs779597975
Pathogenic - Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease|not provided [MONDO:MONDO:0060583,MedGen:C4540232,OMIM:617718|MedGen:C3661900]
275_ALA THR gnomAD
chr7:98990333 		rs780469495
- 0.000146319 -
276_ALA THR gnomAD
chr7:98990336 		rs780914634
- 0.000145845 -
278_MET ILE gnomAD
chr7:98990344 		rs200163199
- 0.000296241 -
280_SER THR 8.3kJPN
chr7:98990349 		-
- 0.0001 -
350_MET ARG gnomAD
chr7:98991711 		rs151225927
- 0.000708937 -
359_VAL MET 8.3kJPN
chr7:98991737 		rs765193066
- 0.0005 -
364_SER LEU gnomAD
chr7:98992084 		rs144187782
- 0.00155214 -
370_LYS ARG gnomAD
chr7:98992102 		rs761120674
- 0.000139433 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.