PDB ID 1K8K     CHAIN C
Protein name ARP2/3 COMPLEX 41 KDA SUBUNIT
Uniprot Accession Q58CQ2
The number of similar proteins 20
The number of binding states 4
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1K8K (CHAIN: C)
1 Q3SYX9   Q148J6   A7MB62  
2 Q3SYX9   Q148J6  
3 Q3SYX9   Q148J6   Q3MHR7   A7MB62  
4 Q3SYX9   Q148J6   Q3MHR7   A7MB62   Q9ERL7  

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Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MAYHSFLVEP   ISCHAWNKDR   TQIAICPNNH   EVHIYEKSGN   KWVQVHELKE   50
51   HNGQVTGVDW   APDSNRIVTC   GTDRNAYVWT   LKGRTWKPTL   VILRINRAAR   100
101   CVRWAPNEKK   FAVGSGSRVI   SICYFEQEND   WWVCKHIKKP   IRSTVLSLDW   150
151   HPNSVLLAAG   SCDFKCRIFS   AYIKEVEERP   APTPWGSKMP   FGELMFESSS   200
201   SCGWVHGVCF   SANGSRVAWV   SHDSTVCLAD   ADKKMAVATL   ASETLPLLAV   250
251   TFITESSLVA   AGHDCFPVLF   TYDSAAGKLS   FGGRLDVPKQ   SSQRGLTARE   300
301   RFQNLDKKAS   SEGSAAAGAG   LDSLHKNSVS   QISVLSGGKA   KCSQFCTTGM   350
351   DGGMSIWDVR   SLESALKDLK   IV       400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
8_VAL LEU 4.7kJPN
chr7:98983359
-
- 0.0001 -
14_HIS ASP 4.7kJPN
chr7:98983377
-
- 0.0002 -
37_LYS ASN 4.7kJPN
chr7:98984354
rs1045012
- 0.0158 -
66_ARG GLY 4.7kJPN
chr7:98985688
-
- 0.0001 -
103_ARG HIS 4.7kJPN
chr7:98985800
rs11556758
- 0.0001 -
105_ALA VAL ClinVar
chr7:98985806
rs1186149065
Pathogenic - PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASE [MedGen:C4540232,OMIM:617718]
113_VAL MET 4.7kJPN
chr7:98985829
-
- 0.0001 -
144_THR ILE 4.7kJPN
chr7:98987566
rs1346643217
- 0.0001 -
145_VAL ILE 4.7kJPN
chr7:98987568
rs1192417300
- 0.0001 -
180_PRO LEU 4.7kJPN
chr7:98988554
rs759537436
- 0.0001 -
208_VAL ILE 4.7kJPN
chr7:98988637
rs371760619
- 0.0003 -
226_VAL ILE 4.7kJPN
chr7:98988691
rs756502444
- 0.0002 -
359_VAL MET 4.7kJPN
chr7:98991737
rs765193066
- 0.0003 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.