PDB ID 1IZN     CHAIN A
Protein name CapZ alpha-1 subunit
Uniprot Accession P13127
The number of similar proteins 12
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1IZN (CHAIN: A)
1 P14315  
2 P14315   Q6EDY6  
3 P14315   Q6EDY6  
4 P14315   P62774  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MADFEDRVSD   EEKVRIAAKF   ITHAPPGEFN   EVFNDVRLLL   NNDNLLREGA   50
51   AHAFAQYNMD   QFTPVKIEGY   DDQVLITEHG   DLGNGRFLDP   RNKISFKFDH   100
101   LRKEASDPQP   EDTESALKQW   RDACDSALRA   YVKDHYPNGF   CTVYGKSIDG   150
151   QQTIIACIES   HQFQPKNFWN   GRWRSEWKFT   ITPPTAQVAA   VLKIQVHYYE   200
201   DGNVQLVSHK   DIQDSVQVSS   DVQTAKEFIK   IIENAENEYQ   TAISENYQTM   250
251   SDTTFKALRR   QLPVTRTKID   WNKILSYKIG   KEMQNA     300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
10_ASP ASN gnomAD
chr1:113162494 		rs41283062
- 0.0122157 -
12_GLU LYS gnomAD
chr1:113162500 		rs149653791
- 0.00192834 -
18_ALA THR gnomAD
chr7:116528193 		rs201789411
- 0.000299664 -
18_ALA VAL 8.3kJPN
chr7:116528194 		-
- 0.0002 -
23_HIS ARG 8.3kJPN
chr7:116528209 		-
- 0.0001 -
34_ASN SER 8.3kJPN
chr1:113189893 		rs202216073
- 0.0001 -
34_ASN SER 8.3kJPN
chr7:116528242 		-
- 0.0001 -
36_VAL PHE 8.3kJPN
chr1:113192042 		rs753793163
- 0.0001 -
44_ASN SER gnomAD
chr1:113192067 		rs76726860
- 0.000286821 -
44_ASN SER 8.3kJPN
chr1:113192067 		rs76726860
- 0.0088 -
60_ASP ASN 8.3kJPN
chr1:113196242 		rs776501930
- 0.0001 -
81_ASP ASN gnomAD
chr7:116544252 		rs370326853
- 0.000497754 -
90_PRO SER 8.3kJPN
chr1:113197135 		-
- 0.0001 -
92_ASN LYS gnomAD
chr1:113197143 		rs371346893
- 0.000406151 -
94_ILE MET gnomAD
chr7:116544293 		rs144500777
- 0.000202893 -
100_HIS GLN 8.3kJPN
chr7:116544311 		-
- 0.0002 -
103_LYS GLU 8.3kJPN
chr7:116544318 		-
- 0.0001 -
112_GLU LYS gnomAD
chr1:113197201 		rs201525157
- 0.000263145 -
120_TRP CYS 8.3kJPN
chr1:113197227 		-
- 0.0001 -
126_SER ASN 8.3kJPN
chr1:113197244 		-
- 0.0001 -
135_HIS TYR gnomAD
chr1:113197270 		rs201509858
- 0.000264247 -
143_VAL ILE 8.3kJPN
chr1:113201644 		rs766629648
- 0.0001 -
148_ILE THR 8.3kJPN
chr1:113201660 		-
- 0.0002 -
154_ILE THR gnomAD
chr1:113201678 		rs552715621
- 0.000139359 -
157_CYS TYR 8.3kJPN
chr1:113201687 		-
- 0.0001 -
181_ILE VAL gnomAD
chr7:116550321 		rs141641730
- 0.000417907 -
181_ILE VAL 8.3kJPN
chr7:116550321 		rs141641730
- 0.0001 -
211_ASP GLU gnomAD
chr1:113209743 		rs199731043
- 0.00013179 -
215_SER CYS gnomAD
chr7:116552181 		rs140848019
- 0.000657334 -
226_LYS ARG gnomAD
chr1:113212184 		rs147970114
- 0.000155925 -
232_VAL ILE 8.3kJPN
chr7:116556150 		rs1347428109
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.