PDB ID 1IVO     CHAIN A
Protein name Epidermal Growth Factor Receptor
Uniprot Accession P00533
The number of similar proteins 19
The number of binding states 9
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1IVO (CHAIN: A)
1 P00533   P01133  
2 Monomeric state
3 3QWQ  
4 P01133  
5 E0ACT6  
6 4UV7   4UV7  
7 5XWD   5XWD  
8 1YY9   1YY9  
9 4KRO   4KRO   4KRO  

Downdload

Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   LEEKKVCQGT   SNKLTQLGTF   EDHFLSLQRM   FNNCEVVLGN   LEITYVQRNY   50
51   DLSFLKTIQE   VAGYVLIALN   TVERIPLENL   QIIRGNMYYE   NSYALAVLSN   100
101   YDANKTGLKE   LPMRNLQEIL   HGAVRFSNNP   ALCNVESIQW   RDIVSSDFLS   150
151   NMSMDFQNHL   GSCQKCDPSC   PNGSCWGAGE   ENCQKLTKII   CAQQCSGRCR   200
201   GKSPSDCCHN   QCAAGCTGPR   ESDCLVCRKF   RDEATCKDTC   PPLMLYNPTT   250
251   YQMDVNPEGK   YSFGATCVKK   CPRNYVVTDH   GSCVRACGAD   SYEMEEDGVR   300
301   KCKKCEGPCR   KVCNGIGIGE   FKDSLSINAT   NIKHFKNCTS   ISGDLHILPV   350
351   AFRGDSFTHT   PPLDPQELDI   LKTVKEITGF   LLIQAWPENR   TDLHAFENLE   400
401   IIRGRTKQHG   QFSLAVVSLN   ITSLGLRSLK   EISDGDVIIS   GNKNLCYANT   450
451   INWKKLFGTS   GQKTKIISNR   GENSCKATGQ   VCHALCSPEG   CWGPEPRDCV   500
501   SCRNVSRGRE   CVDKCNLLEG   EPREFVENSE   CIQCHPECLP   QAMNITCTGR   550
551   GPDNCIQCAH   YIDGPHCVKT   CPAGVMGENN   TLVWKYADAG   HVCHLCHPNC   600
601   TYGCTGPGLE   GCPTNGPKIP   SI       650

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
11_SER ASN 4.7kJPN
chr7:55209994
rs1406387936
- 0.0001 -
74_ARG GLN VAR_019293 rs17289589
Polymorphism - -
84_ARG LYS ClinVar
chr7:55211080
rs1057519828
Likely pathogenic - Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
84_ARG GLY ClinVar
chr7:55211079
rs1057519888
Likely pathogenic - Brainstem glioma [Human Phenotype Ontology:HP:0010796,MedGen:C0677865]; Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
215_GLY ALA 4.7kJPN
chr7:55220326
rs1447176163
- 0.0002 -
220_ARG TRP 4.7kJPN
chr7:55220340
rs554981236
- 0.0001 -
239_THR PRO ClinVar
chr7:55221743
rs1057519829
Likely pathogenic - Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
242_PRO ARG VAR_019294 rs17336639
Polymorphism - -
258_GLU LYS 4.7kJPN
chr7:55221800
rs199796955
- 0.0001 -
265_ALA VAL ClinVar
chr7:55221822
rs149840192
Likely pathogenic - Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
265_ALA THR ClinVar
chr7:55221821
rs769696078
Likely pathogenic - Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
265_ALA ASP ClinVar
chr7:55221822
rs149840192
Likely pathogenic - Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
302_CYS PHE ClinVar
chr7:55223610
rs886037891
Pathogenic - Cowden syndrome 1 [MedGen:CN072330,OMIM:158350]
306_GLU LYS ClinVar
chr7:55223621
rs139429793
Pathogenic - Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]
404_GLY ASP VAR_072435 rs606231253
Disease - Inflammatory skin and bowel disease, neonatal, 2 (NISBD2) [MIM:616069]
404_GLY ASP ClinVar
chr7:55225431
rs606231253
Pathogenic - Inflammatory skin and bowel disease, neonatal, 2 [MedGen:C4015130,OMIM:616069]
418_SER ASN 4.7kJPN
chr7:55227858
rs765091640
- 0.0013 -
468_SER GLY ClinVar
chr7:55228007
rs1057519760
Likely pathogenic - Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]
494_PRO LEU 4.7kJPN
chr7:55229246
rs564398642
- 0.0001 -
497_ARG LYS VAR_019295 rs2227983
Polymorphism - -
497_ARG LYS 4.7kJPN
chr7:55229255
rs2227983
- 0.6168 -
504_ASN ASP 4.7kJPN
chr7:55229275
rs762336338
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.