PDB ID 1IAR     CHAIN B
Protein name PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN)
Uniprot Accession P24394
The number of similar proteins 5
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1IAR (CHAIN: B)
1 P05112  
2 P78552   P35225  
3 P05112   P78552  
4 P05112   P31785  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   FKVLQEPTCV   SDYMSISTCE   WKMNGPTNCS   TELRLLYQLV   FLLSEAHTCI   50
51   PENNGGAGCV   CHLLMDDVVS   ADNYTLDLWA   GQQLLWKGSF   KPSEHVKPRA   100
101   PGNLTVHTNV   SDTLLLTWSN   PYPPDNYLYN   HLTYAVNIWS   ENDPADFRIY   150
151   NVTYLEPSLR   IAASTLKSGI   SYRARVRAWA   QAYNTTWSEW   SPSTKWHNSY   200
201   REPFEQH           250

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
10_VAL ILE 8.3kJPN
chr16:27353474
rs372988882
- 0.0001 -
18_THR ALA 8.3kJPN
chr16:27353498
rs749110570
- 0.0005 -
28_ASN SER gnomAD
chr16:27353529
rs201852059
- 0.000163047 -
28_ASN ILE 8.3kJPN
chr16:27353529
rs201852059
- - -
34_ARG CYS 8.3kJPN
chr16:27353546
rs191774649
- 0.0013 -
40_VAL PHE gnomAD
chr16:27353564
rs555743307
- 0.000286353 -
44_SER PHE 8.3kJPN
chr16:27353577
-
- 0.0001 -
50_ILE VAL VAR_008034 rs1805010
Polymorphism - -
50_ILE PHE VAR_059302 rs1805010
Polymorphism - -
50_ILE LEU VAR_059303 rs1805010
Polymorphism - -
50_ILE VAL ClinVar
chr16:27356203
rs1805010
Pathogenic, protective - Acquired immunodeficiency syndrome, slow progression to [MedGen:C1840084]; Atopy, resistance to [MedGen:C4016232]
50_ILE VAL gnomAD
chr16:27356203
rs1805010
- 0.447775 -
50_ILE VAL 8.3kJPN
chr16:27356203
rs1805010
- 0.6196 -
57_ALA THR gnomAD
chr16:27356224
rs144651842
- 0.0127006 -
57_ALA THR 8.3kJPN
chr16:27356224
rs144651842
- 0.0652 -
60_VAL MET gnomAD
chr16:27356233
rs141983833
- 0.000202953 -
89_SER PHE gnomAD
chr16:27356321
rs543167942
- 0.000171399 -
90_PHE ILE gnomAD
chr16:27356323
rs199703000
- 0.000685652 -
91_LYS ASN 8.3kJPN
chr16:27356328
-
- 0.0001 -
94_GLU LYS gnomAD
chr16:27356335
rs141903283
- 0.000299578 -
95_HIS ARG 8.3kJPN
chr16:27356339
-
- 0.0001 -
133_THR SER 8.3kJPN
chr16:27357898
-
- 0.0001 -
143_ASP ASN 8.3kJPN
chr16:27357928
rs568385218
- 0.001 -
143_ASP GLU 8.3kJPN
chr16:27357930
rs775265328
- 0.0001 -
144_PRO LEU gnomAD
chr16:27357932
rs145473866
- 0.000107464 -
160_ARG HIS gnomAD
chr16:27363901
rs150955128
- 0.0149458 -
160_ARG HIS 8.3kJPN
chr16:27363901
rs150955128
- 0.0035 -
175_ARG TRP 8.3kJPN
chr16:27363945
rs370524692
- 0.0001 -
175_ARG GLN 8.3kJPN
chr16:27363946
rs147547377
- 0.0047 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.