PDB ID 1IAR     CHAIN B
Protein name PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN)
Uniprot Accession P24394
The number of similar proteins 5
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1IAR (CHAIN: B)
1 P05112  
2 P78552   P35225  
3 P05112   P78552  
4 P05112   P31785  

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Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   FKVLQEPTCV   SDYMSISTCE   WKMNGPTNCS   TELRLLYQLV   FLLSEAHTCI   50
51   PENNGGAGCV   CHLLMDDVVS   ADNYTLDLWA   GQQLLWKGSF   KPSEHVKPRA   100
101   PGNLTVHTNV   SDTLLLTWSN   PYPPDNYLYN   HLTYAVNIWS   ENDPADFRIY   150
151   NVTYLEPSLR   IAASTLKSGI   SYRARVRAWA   QAYNTTWSEW   SPSTKWHNSY   200
201   REPFEQH           250

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
18_THR ALA 4.7kJPN
chr16:27353498
rs749110570
- 0.0004 -
34_ARG CYS 4.7kJPN
chr16:27353546
rs191774649
- 0.0012 -
50_ILE VAL VAR_008034 rs1805010
Polymorphism - -
50_ILE PHE VAR_059302 rs1805010
Polymorphism - -
50_ILE LEU VAR_059303 rs1805010
Polymorphism - -
50_ILE VAL ClinVar
chr16:27356203
rs1805010
Pathogenic, protective - Acquired immunodeficiency syndrome, slow progression to [MedGen:C1840084]; Atopy, resistance to [MedGen:C4016232]
50_ILE VAL 4.7kJPN
chr16:27356203
rs1805010
- 0.6173 -
57_ALA THR 4.7kJPN
chr16:27356224
rs144651842
- 0.0696 -
95_HIS ARG 4.7kJPN
chr16:27356339
-
- 0.0001 -
143_ASP ASN 4.7kJPN
chr16:27357928
rs568385218
- 0.0015 -
160_ARG HIS 4.7kJPN
chr16:27363901
rs150955128
- 0.003 -
175_ARG TRP 4.7kJPN
chr16:27363945
rs370524692
- 0.0002 -
175_ARG GLN 4.7kJPN
chr16:27363946
rs147547377
- 0.0042 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.