PDB ID 1HVV     CHAIN A
Protein name SYNTAXIN 1A
Uniprot Accession P32851
The number of similar proteins 21
The number of binding states 9
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   QALSEIETRH   SEIIKLENSI   RELHDMFMDM   AMLVESQGEM   IDRIEYNVEH   50
51   AVDYVERAVS   DTKKAVKYQS   KARRK       100

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
200_SER GLY 4.7kJPN
chr7:73117255
-
- 0.0001 -
217_VAL GLU ClinVar
chr16:31004696
rs724159974
Pathogenic - Generalized epilepsy with febrile seizures plus, type 9 [MedGen:C4015395,OMIM:616172]
227_GLY ARG ClinVar
chr16:31004561
rs727502806
Pathogenic - Generalized epilepsy with febrile seizures plus, type 9 [MedGen:C4015395,OMIM:616172]
240_SER PRO ClinVar
chr16:31004522
rs1555493906
Likely pathogenic - not provided [MedGen:CN517202]
246_ARG TER ClinVar
chr16:31004504
-
Pathogenic - Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.