PiSITE

PDB ID	1HVV	CHAIN	A
Protein name	SYNTAXIN 1A
Uniprot Accession	P32851
The number of similar proteins	21
The number of binding states	9
The number of binding partners	7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1HVV (CHAIN: A)
1	P32851 P32851 P32851
2	P32851 P60881 P60881
3	P60881 P60881 P63045
4	1URQ 1URQ 1URQ
5	P21579 P60880 P60880 P63045
6	O14810 P60880 P60880 P63027
7	P21707 P21707 P60881 P60881 P63045
8	P21707 P63041 P60881 P60881 P63045
9	P21707 P21707 P21707 P60881 P60881 P63045

Downdload

Molecule viewer

Only interaction residues

#binding
partners

	4
	3
	2
	1
	0

Sequence information

1

QALSEIETRH

SEIIKLENSI

RELHDMFMDM

AMLVESQGEM

IDRIEYNVEH

50

51

AVDYVERAVS

DTKKAVKYQS

KARRK

100

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
	200_SER	GLY	8.3kJPN chr7:73117255	-	-	0.0001	-
	217_VAL	GLU	ClinVar chr16:31004696	rs724159974	Pathogenic	-	Generalized epilepsy with febrile seizures plus, type 9 [MedGen:C4015395,OMIM:616172]
	221_MET	ARG	8.3kJPN chr7:73117191	-	-	0.0001	-
	221_MET	VAL	8.3kJPN chr16:31004685	rs1567376776	-	0.0001	-
	227_GLY	ARG	ClinVar chr16:31004561	rs727502806	Pathogenic	-	Generalized epilepsy with febrile seizures plus, type 9 [MedGen:C4015395,OMIM:616172]
	240_SER	PRO	ClinVar chr16:31004522	rs1555493906	Likely pathogenic	-	not provided [MedGen:CN517202]
	246_ARG	TER	ClinVar chr16:31004504	-	Pathogenic	-	Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364