PDB ID 1GG2     CHAIN B
Protein name G PROTEIN GI BETA 1
Uniprot Accession P62871
The number of similar proteins 42
The number of binding states 9
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1GG2 (CHAIN: B)
1 P63212   P63096  
2 P63212  
3 P63212   P21146  
4 P02698   P20942  
5 P02698   6B20  
6 P04901   P04901   P02698  
7 P59768   Q8C4T8   Q8C4T8  
8 6CRK   P59768   P63096  
9 P63212   P04896   P00720   3SN6  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MSELDQLRQE   AEQLKNQIRD   ARKACADATL   SQITNNIDPV   GRIQMRTRRT   50
51   LRGHLAKIYA   MHWGTDSRLL   VSASQDGKLI   IWDSYTTNKV   HAIPLRSSWV   100
101   MTCAYAPSGN   YVACGGLDNI   CSIYNLKTRE   GNVRVSRELA   GHTGYLSCCR   150
151   FLDDNQIVTS   SGDTTCALWD   IETGQQTTTF   TGHTGDVMSL   SLAPDTRLFV   200
201   SGACDASAKL   WDVREGMCRQ   TFTGHESDIN   AICFFPNGNA   FATGSDDATC   250
251   RLFDLRADQE   LMTYSHDNII   CGITSVSFSK   SGRLLLAGYD   DFNCNVWDAL   300
301   KADRAGVLAG   HDNRVSCLGV   TDDGMAVATG   SWDSFLKIWN     350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_GLU LYS 8.3kJPN
chr3:179143982 		rs955229785
- 0.0001 -
8_ARG HIS 8.3kJPN
chr12:6950474 		rs199531660
- 0.0004 -
11_ALA VAL 8.3kJPN
chr12:6950483 		rs782550076
- 0.0001 -
19_ARG GLN 8.3kJPN
chr7:100273944 		-
- 0.0001 -
21_ALA VAL 8.3kJPN
chr7:100274162 		-
- 0.0001 -
22_ARG GLN 8.3kJPN
chr3:179138708 		rs1318528118
- 0.0001 -
24_ALA VAL 8.3kJPN
chr12:6950763 		-
- 0.0001 -
29_THR ALA 8.3kJPN
chr1:1749287 		rs758197716
- 0.0001 -
29_THR MET 8.3kJPN
chr3:179138687 		rs762114369
- 0.0002 -
30_LEU VAL 8.3kJPN
chr12:6950780 		rs1429928202
- 0.0001 -
31_THR SER 8.3kJPN
chr7:100274192 		-
- 0.0002 -
37_ILE MET gnomAD
chr1:1747287 		rs754777749
- 0.000151198 -
43_ILE MET 8.3kJPN
chr3:179137261 		rs1187523844
- 0.0002 -
47_THR MET gnomAD
chr12:6952177 		rs116400596
- 0.000141787 -
47_THR MET 8.3kJPN
chr12:6952177 		rs116400596
- 0.0001 -
49_ARG GLN 8.3kJPN
chr12:6952183 		rs782393502
- 0.0001 -
53_GLY ASP ClinVar
chr3:179137232 		rs387907340
Pathogenic - Charcot-Marie-Tooth disease, dominant intermediate F [MedGen:C3554654,OMIM:615185,Orphanet:ORPHA352670]
57_LYS GLU 8.3kJPN
chr1:1747229 		rs141326438
- 0.0002 -
59_TYR ASP 8.3kJPN
chr12:6952212 		-
- 0.0001 -
60_ALA THR 8.3kJPN
chr12:6952215 		rs782554195
- 0.0001 -
63_TRP CYS 8.3kJPN
chr7:100274408 		-
- 0.0001 -
66_ASP HIS 8.3kJPN
chr7:100274415 		-
- 0.0001 -
67_SER PHE ClinVar
chr12:6952237 		rs140263599
Pathogenic - Night blindness, congenital stationary, type 1h [MedGen:C4310758,OMIM:617024]
76_ASP GLU ClinVar
chr1:1737953 		rs869312822
Pathogenic - Failure to thrive [Human Phenotype Ontology:HP:0001508,MedGen:C2315100]; Focal seizures with impairment of consciousness or awareness [Human Phenotype Ontology:HP:0002384,MedGen:C0270834]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Limb hypertonia [Human Phenotype Ontology:HP:0002509,MedGen:C1838391]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]; Strabismus [Human Phenotype Ontology:HP:0000486,MedGen:C0038379]
76_ASP GLY ClinVar
chr1:1737954 		rs869312821
Pathogenic - Acute lymphoid leukemia [MedGen:C0023449,OMIM:613065,Orphanet:ORPHA513,SNOMED CT:91857003]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Infantile muscular hypotonia [Human Phenotype Ontology:HP:0008947,MedGen:C1860834]; Intellectual disability [Human Phenotype Ontology:HP:0001249,MedGen:C1843367]; Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]
76_ASP TYR 8.3kJPN
chr12:6952360 		rs2234756
- 0.0094 -
77_GLY SER ClinVar
chr1:1737952 		rs758432471
Likely pathogenic - Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]
77_GLY ALA ClinVar
chr1:1737951 		rs1135401746
Likely pathogenic - Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]
78_LYS ARG ClinVar
chr1:1737948 		rs869312823
Pathogenic - EEG with generalized epileptiform discharges [Human Phenotype Ontology:HP:0011198,MedGen:C4023476]; Feeding difficulties [Human Phenotype Ontology:HP:0011968,MedGen:C0232466]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Growth delay [Human Phenotype Ontology:HP:0001510,MedGen:C0456070]; Infantile muscular hypotonia [Human Phenotype Ontology:HP:0008947,MedGen:C1860834]; Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]; Strabismus [Human Phenotype Ontology:HP:0000486,MedGen:C0038379]; not provided [MedGen:CN517202]
80_ILE THR ClinVar
chr1:1737942 		rs752746786
Pathogenic - Cleft palate [Human Phenotype Ontology:HP:0000175,MedGen:C0008925,Orphanet:ORPHA2014]; Developmental regression [Human Phenotype Ontology:HP:0002376,MedGen:C1836830]; Dystonia [Human Phenotype Ontology:HP:0001332,MedGen:C0013421]; EEG with generalized epileptiform discharges [Human Phenotype Ontology:HP:0011198,MedGen:C4023476]; Expressive language delay [Human Phenotype Ontology:HP:0002474,MedGen:C0454641]; Failure to thrive [Human Phenotype Ontology:HP:0001508,MedGen:C2315100]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Growth delay [Human Phenotype Ontology:HP:0001510,MedGen:C0456070]; Growth delay [Human Phenotype Ontology:HP:0001510,MedGen:C0456070]; Hypothyroidism [Human Phenotype Ontology:HP:0000821,MedGen:C0020676,Orphanet:ORPHA181396]; Inability to walk [Human Phenotype Ontology:HP:0002540,MedGen:C0560046]; Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Infantile axial hypotonia [Human Phenotype Ontology:HP:0009062,MedGen:C3806604]; Intellectual disability [Human Phenotype Ontology:HP:0001249,MedGen:C1843367]; Limb hypertonia [Human Phenotype Ontology:HP:0002509,MedGen:C1838391]; Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]; Multifocal epileptiform discharges [Human Phenotype Ontology:HP:0010841,MedGen:C4021219]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Myelodysplastic syndrome [MeSH:D009190,MedGen:C3463824,OMIM:614286,Orphanet:ORPHA52688]; Nystagmus [Human Phenotype Ontology:HP:0000639,MedGen:C0028738]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]; Strabismus [Human Phenotype Ontology:HP:0000486,MedGen:C0038379]; Upper limb hypertonia [Human Phenotype Ontology:HP:0200049,MedGen:C4021898]; not provided [MedGen:CN517202]
80_ILE ASN ClinVar
chr1:1737942 		rs752746786
Pathogenic - Acute lymphoid leukemia [MedGen:C0023449,OMIM:613065,Orphanet:ORPHA513,SNOMED CT:91857003]; Cortical visual impairment [Human Phenotype Ontology:HP:0100704,MedGen:C4048268]; Failure to thrive [Human Phenotype Ontology:HP:0001508,MedGen:C2315100]; Feeding difficulties [Human Phenotype Ontology:HP:0011968,MedGen:C0232466]; Focal seizures with impairment of consciousness or awareness [Human Phenotype Ontology:HP:0002384,MedGen:C0270834]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Growth delay [Human Phenotype Ontology:HP:0001510,MedGen:C0456070]; Infantile muscular hypotonia [Human Phenotype Ontology:HP:0008947,MedGen:C1860834]; Limb hypertonia [Human Phenotype Ontology:HP:0002509,MedGen:C1838391]; Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]; Multifocal epileptiform discharges [Human Phenotype Ontology:HP:0010841,MedGen:C4021219]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]
80_ILE SER ClinVar
chr1:1737942 		rs752746786
Pathogenic - not provided [MedGen:CN517202]
81_VAL MET 8.3kJPN
chr12:6952375 		rs45616032
- 0.0001 -
87_THR ALA gnomAD
chr3:179134289 		rs780046027
- 0.000244076 -
89_LYS GLU ClinVar
chr3:179134283 		rs387907341
Pathogenic - Charcot-Marie-Tooth disease, dominant intermediate F [MedGen:C3554654,OMIM:615185,Orphanet:ORPHA352670]
89_LYS ARG ClinVar
chr1:1737915 		rs1064795844
Likely pathogenic - not provided [MedGen:CN517202]
94_PRO LEU 8.3kJPN
chr12:6952540 		rs999189577
- 0.0001 -
95_LEU PRO ClinVar
chr1:1736004 		rs869312824
Pathogenic - Cortical visual impairment [Human Phenotype Ontology:HP:0100704,MedGen:C4048268]; Expressive language delay [Human Phenotype Ontology:HP:0002474,MedGen:C0454641]; Failure to thrive [Human Phenotype Ontology:HP:0001508,MedGen:C2315100]; Feeding difficulties [Human Phenotype Ontology:HP:0011968,MedGen:C0232466]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Growth delay [Human Phenotype Ontology:HP:0001510,MedGen:C0456070]; Inability to walk [Human Phenotype Ontology:HP:0002540,MedGen:C0560046]; Intellectual disability [Human Phenotype Ontology:HP:0001249,MedGen:C1843367]; Limb hypertonia [Human Phenotype Ontology:HP:0002509,MedGen:C1838391]; Multifocal epileptiform discharges [Human Phenotype Ontology:HP:0010841,MedGen:C4021219]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Nystagmus [Human Phenotype Ontology:HP:0000639,MedGen:C0028738]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]; Strabismus [Human Phenotype Ontology:HP:0000486,MedGen:C0038379]
101_MET VAL ClinVar
chr1:1735987 		rs869312825
Pathogenic/Likely pathogenic - Developmental regression [Human Phenotype Ontology:HP:0002376,MedGen:C1836830]; EEG with generalized epileptiform discharges [Human Phenotype Ontology:HP:0011198,MedGen:C4023476]; Expressive language delay [Human Phenotype Ontology:HP:0002474,MedGen:C0454641]; Focal seizures with impairment of consciousness or awareness [Human Phenotype Ontology:HP:0002384,MedGen:C0270834]; Generalized tonic-clonic seizures [Human Phenotype Ontology:HP:0002069,MedGen:C0494475]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Intellectual disability [Human Phenotype Ontology:HP:0001249,MedGen:C1843367]; Mental retardation, autosomal dominant 42 [MedGen:C4310774,OMIM:616973]; Multifocal epileptiform discharges [Human Phenotype Ontology:HP:0010841,MedGen:C4021219]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]; not provided [MedGen:CN517202]
106_ALA THR 8.3kJPN
chr7:100275169 		-
- 0.0001 -
107_PRO SER 8.3kJPN
chr3:179132784 		-
- 0.0001 -
108_SER PHE 8.3kJPN
chr3:179132780 		-
- 0.0003 -
115_GLY ARG 8.3kJPN
chr12:6952602 		rs201963490
- 0.0002 -
118_ASP GLY ClinVar
chr1:1735935 		rs1553194162
Pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
123_ILE VAL 8.3kJPN
chr12:6952626 		rs782780703
- 0.0001 -
125_ASN SER 8.3kJPN
chr1:1735914 		rs150628410
- 0.0002 -
127_LYS ARG 8.3kJPN
chr12:6952639 		rs1555123844
- 0.0005 -
129_ARG HIS 8.3kJPN
chr12:6952645 		rs201797921
- 0.0002 -
130_GLU LYS ClinVar
chr1:1735900 		rs1553194155
Likely pathogenic - not provided [MedGen:CN517202]
133_VAL MET 8.3kJPN
chr3:179132706 		-
- 0.0001 -
134_LYS ARG gnomAD
chr12:6952660 		rs61747607
- 0.000560783 -
143_THR ILE 8.3kJPN
chr3:179132675 		-
- 0.0001 -
175_GLN HIS 8.3kJPN
chr7:100275748 		rs1187109793
- 0.0002 -
177_THR ASN 8.3kJPN
chr3:179131369 		rs1274879698
- 0.0003 -
178_THR ILE 8.3kJPN
chr12:6952976 		-
- 0.0001 -
187_VAL ALA 8.3kJPN
chr7:100275783 		-
- 0.0001 -
195_ASP ASN gnomAD
chr7:100275806 		rs79631023
- 0.000751575 -
200_VAL LEU 8.3kJPN
chr7:100275821 		-
- 0.0001 -
208_ILE VAL 8.3kJPN
chr7:100275845 		rs752126417
- 0.0003 -
214_ARG TER 8.3kJPN
chr12:6953083 		rs367934996
- 0.0001 -
219_ARG CYS 8.3kJPN
chr12:6953098 		rs782266619
- 0.0002 -
220_GLN ARG 8.3kJPN
chr3:179131240 		rs199615251
- 0.0001 -
223_THR MET gnomAD
chr3:179131231 		rs144385061
- 0.000131316 -
226_GLU GLN gnomAD
chr12:6953119 		rs371744474
- 0.000333483 -
226_GLU LYS 8.3kJPN
chr1:1721857 		-
- 0.0001 -
239_ASN SER 8.3kJPN
chr1:1720692 		rs760166038
- 0.0001 -
240_ALA THR 8.3kJPN
chr7:100276039 		-
- 0.0001 -
245_SER LEU 8.3kJPN
chr12:6954784 		rs782597916
- 0.0004 -
251_ARG HIS 8.3kJPN
chr12:6954802 		rs782467023
- 0.0001 -
256_ARG GLN 8.3kJPN
chr12:6954817 		rs781879948
- 0.0001 -
267_GLU LYS gnomAD
chr12:6954849 		rs150593798
- 0.000139228 -
267_ASP ASN 8.3kJPN
chr3:179123095 		rs752762550
- 0.0001 -
268_ASN SER 8.3kJPN
chr1:1720605 		rs757342463
- 0.0002 -
268_ASN ILE 8.3kJPN
chr7:100276124 		rs147810006
- 0.0001 -
268_SER ARG 8.3kJPN
chr12:6954854 		-
- 0.0003 -
271_CYS TYR 8.3kJPN
chr3:179123082 		-
- 0.0001 -
272_GLY SER gnomAD
chr12:6954864 		rs5442
- 0.0484364 -
287_ALA SER 8.3kJPN
chr12:6954909 		rs782090563
- 0.0001 -
289_TYR CYS 8.3kJPN
chr3:179123028 		-
- 0.0001 -
294_CYS ARG 8.3kJPN
chr3:179123014 		-
- 0.0001 -
299_ALA VAL 8.3kJPN
chr1:1720512 		-
- 0.0001 -
304_ARG CYS 8.3kJPN
chr3:179122984 		rs201776673
- 0.0001 -
309_ALA THR 8.3kJPN
chr7:100276326 		rs1554371972
- 0.0001 -
313_ASN SER 8.3kJPN
chr3:179119086 		-
- 0.0001 -
320_VAL ILE gnomAD
chr3:179119066 		rs61750380
- 0.00419188 -
326_ALA THR ClinVar
chr1:1718817 		rs869312826
Pathogenic - Generalized tonic-clonic seizures [Human Phenotype Ontology:HP:0002069,MedGen:C0494475]; Global developmental delay [Human Phenotype Ontology:HP:0001263,MedGen:C0557874]; Intellectual disability [Human Phenotype Ontology:HP:0001249,MedGen:C1843367]; Muscular hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Seizures [Human Phenotype Ontology:HP:0001250,MedGen:C0036572]
330_GLY ASP 8.3kJPN
chr12:6956028 		-
- 0.0001 -
339_TRP TER ClinVar
chr12:6956056 		rs879253773
Pathogenic - Night blindness, congenital stationary, type 1h [MedGen:C4310758,OMIM:617024]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.