PDB ID 1GFW     CHAIN A
Protein name CASPASE-3 (APOPAIN, P20)
Uniprot Accession P42574
The number of similar proteins 64
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1GFW (CHAIN: A)
1 P42574  
2 P42574   2XZT  
3 P42574   P42574   P42574  
4 P42574   P42574   P42574   P98170  
5 P42574   P42574   2CDR   2CDR   2CDR  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   SGISLDNSYK   MDYPEMGLCI   IINNKNFHKS   TGMTSRSGTD   VDAANLRETF   50
51   RNLKYEVRNK   NDLTREEIVE   LMRDVSKEDH   SKRSSFVCVL   LSHGEEGIIF   100
101   GTNGPVDLKK   ITNFFRGDRC   RSLTGKPKLF   IIQACRGTEL   DCGIETD   150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
38_LYS ARG 8.3kJPN
chr4:185556513 		-
- 0.0001 -
101_ARG HIS gnomAD
chr4:185553427 		rs146285839
- 0.000219689 -
101_ARG CYS 8.3kJPN
chr4:185553428 		rs567223280
- 0.0001 -
105_LYS GLU 8.3kJPN
chr4:185553089 		rs1280426773
- 0.0002 -
108_HIS GLN 8.3kJPN
chr4:185553078 		-
- 0.0001 -
135_ASP HIS 8.3kJPN
chr4:185552999 		-
- 0.0001 -
164_ARG CYS 8.3kJPN
chr4:185552305 		rs770145611
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.