PDB ID 1GAG     CHAIN A
Protein name INSULIN RECEPTOR, TYROSINE KINASE DOMAIN
Uniprot Accession P06213
The number of similar proteins 21
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1GAG (CHAIN: A)
1 Monomeric state
2 P06213  
3 Q14449  
4 Q9Z200   Q9Z200  
5 P06213   P18031  

Downdload

Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   VFPSSVFVPD   EWEVSREKIT   LLRELGQGSF   GMVYEGNARD   IIKGEAETRV   50
51   AVKTVNESAS   LRERIEFLNE   ASVMKGFTCH   HVVRLLGVVS   KGQPTLVVME   100
101   LMAHGDLKSY   LRSLRPEAEN   NPGRPPPTLQ   EMIQMAAEIA   DGMAYLNAKK   150
151   FVHRDLAARN   CMVAHDFTVK   IGDFGMTRDI   XETDXXRKGG   KGLLPVRWMA   200
201   PESLKDGVFT   TSSDMWSFGV   VLWEITSLAE   QPYQGLSNEQ   VLKFVMDGGY   250
251   LDQPDNCPER   VTDLMRMCWQ   FNPKMRPTFL   EIVNLLKDDL   HPSFPEVSFF   300
301   HSEENK           350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
985_VAL MET VAR_004091 rs1799816
Polymorphism - -
985_VAL MET 4.7kJPN
chr19:7125518
rs1799816
- 0.0001 -
988_GLU ALA 4.7kJPN
chr19:7125508
-
- 0.0002 -
993_ARG GLN VAR_004092 rs121913148
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
993_ARG GLN ClinVar
chr19:7125493
rs121913148
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
996_ILE PHE VAR_015922 -
Polymorphism - -
1000_ARG TER ClinVar
chr19:7125473
rs121913144
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]; Pineal hyperplasia AND diabetes mellitus syndrome [MedGen:C0271695,OMIM:262190,Orphanet:ORPHA769,SNOMED CT:33559001]
1000_ARG TER 4.7kJPN
chr19:7125473
rs121913144
- 0.0001 -
1008_GLY VAL VAR_004093 rs121913135
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1008_GLY VAL ClinVar
chr19:7125448
rs121913135
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
1021_GLY ASP 4.7kJPN
chr19:7125409
rs200921389
- 0.0065 -
1027_VAL MET VAR_079549 rs1135401741
Unclassified - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1028_ALA VAL VAR_015923 -
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1038_LEU VAL VAR_041432 rs56395521
Polymorphism - -
1038_LEU ILE 4.7kJPN
chr19:7125359
-
- 0.0001 -
1039_ARG GLN 4.7kJPN
chr19:7125355
rs372010924
- 0.0002 -
1041_ARG GLN 4.7kJPN
chr19:7125349
rs367827848
- 0.0001 -
1048_ALA ASP VAR_004094 -
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1055_ASN SER 4.7kJPN
chr15:99478269
rs780382569
- 0.0007 -
1068_LYS GLU VAR_015924 rs909008899
Polymorphism - -
1089_ARG CYS 4.7kJPN
chr19:7122913
rs749951195
- 0.0001 -
1092_ARG TRP VAR_015925 rs1229730671
Disease - Leprechaunism (LEPRCH) [MIM:246200]
1101_ARG HIS 4.7kJPN
chr19:7122771
rs202160383
- 0.0001 -
1113_ALA VAL 4.7kJPN
chr19:7122735
rs772334614
- 0.0001 -
1116_ILE THR VAR_015926 -
Disease - Rabson-Mendenhall syndrome (RMS) [MIM:262190]
1124_ASN HIS 4.7kJPN
chr15:99482511
rs1341344717
- 0.0001 -
1131_ARG GLN VAR_015927 -
Disease - Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]
1131_ARG TRP VAR_015928 rs111993466
Disease - Rabson-Mendenhall syndrome (RMS) [MIM:262190]
1134_ALA THR VAR_004095 rs121913139
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1134_ALA THR ClinVar
chr19:7122673
rs121913139
Pathogenic - Insulin resistance [Human Phenotype Ontology:HP:0000855,MedGen:C0021655]; Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
1135_ALA GLU VAR_004096 rs121913154
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1135_ALA GLU ClinVar
chr19:7122669
rs121913154
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
1141_ALA THR 4.7kJPN
chr15:99482562
-
- 0.0001 -
1142_GLU LYS 4.7kJPN
chr15:99482565
rs769418210
- 0.0001 -
1142_GLU ASP 4.7kJPN
chr15:99482567
rs775334349
- 0.0001 -
1153_MET ILE VAR_004097 rs121913157
Polymorphism - -
1153_MET ILE ClinVar
chr19:7120750
rs121913157
Pathogenic - Insulin resistance [Human Phenotype Ontology:HP:0000855,MedGen:C0021655]
1164_ARG GLN VAR_004098 rs121913150
Disease - Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]
1164_ARG GLN ClinVar
chr19:7120718
rs121913150
Pathogenic - Diabetes mellitus type 2 [Human Phenotype Ontology:HP:0005978,MedGen:C0011860,OMIM:125853,Orphanet:ORPHA181376,SNOMED CT:44054006]
1174_ARG GLN VAR_015929 rs121913156
Disease - Familial hyperinsulinemic hypoglycemia 5 (HHF5) [MIM:609968]
1174_ARG TRP VAR_015930 -
Disease - Leprechaunism (LEPRCH) [MIM:246200]
1174_ARG GLN ClinVar
chr19:7120688
rs121913156
Pathogenic - Hyperinsulinemic hypoglycemia familial 5 [MedGen:C1864952,OMIM:609968,Orphanet:ORPHA263458]; Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
1178_PRO LEU VAR_004099 rs1295645322
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1179_GLU ASP VAR_015931 -
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1179_GLU LYS VAR_015932 -
Disease - Leprechaunism (LEPRCH) [MIM:246200]
1193_TRP LEU VAR_004100 rs52800171
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1194_SER ALA 4.7kJPN
chr19:7119593
rs201979105
- 0.0005 -
1200_TRP SER VAR_004101 rs121913140
Disease - Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1200_TRP SER ClinVar
chr19:7119574
rs121913140
Pathogenic - Insulin-resistant diabetes mellitus AND acanthosis nigricans [MedGen:C0342278,OMIM:610549,SNOMED CT:9859006]
1203_THR SER 4.7kJPN
chr19:7119565
-
- 0.0001 -
1226_GLY SER 4.7kJPN
chr15:99491900
rs368518102
- 0.0004 -
1227_TYR ASP 4.7kJPN
chr19:7119494
-
- 0.0006 -
1231_PRO THR 4.7kJPN
chr15:99491915
rs751193576
- 0.0001 -
1243_ARG HIS 4.7kJPN
chr19:7117407
rs746000108
- 0.0003 -
1255_THR ALA VAR_041433 rs55875349
Polymorphism - -
1267_MET VAL 4.7kJPN
chr15:99500375
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.