PDB ID 1G0X     CHAIN A
Protein name LEUCOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR-1
Uniprot Accession Q8NHL6
The number of similar proteins 11
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1G0X (CHAIN: A)
1 Monomeric state
2 Q8NHL6  
3 P61769   P01892  
4 P61769   Q4A1U8  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   HLPKPTLWAE   PGSVITQGSP   VTLRCQGGQE   TQEYRLYREK   KTAPWITRIP   50
51   QELVKKGQFP   IPSITWEHAG   RYRCYYGSDT   AGRSESSDPL   ELVVTGAYIK   100
101   PTLSAQPSPV   VNSGGNVTLQ   CDSQVAFDGF   ILCKEGEDEH   PQCLNSQPHA   150
151   RGSSRAIFSV   GPVSPSRRWW   YRCYAYDSNS   PYEWSLPSDL   LELLVLG   200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
2_HIS LEU gnomAD
chr19:55085771 		rs1834697
- 0.00542106 -
3_LEU ILE gnomAD
chr19:54803748 		rs139099303
- 0.00355955 -
3_LEU HIS gnomAD
chr19:55142957 		rs201224544
- 0.00103901 -
3_LEU ILE 8.3kJPN
chr19:54803748 		rs139099303
- 0.3846 -
13_GLY ASP 8.3kJPN
chr19:55085804 		rs535758926
- 0.0001 -
14_SER ALA 8.3kJPN
chr19:54783892 		-
- 0.0001 -
17_THR ILE gnomAD
chr19:54783882 		rs75728057
- 0.000159131 -
17_THR PRO gnomAD
chr19:55106177 		rs142517538
- 0.000617766 -
17_THR ILE 8.3kJPN
chr19:54783882 		rs75728057
- 0.0112 -
17_THR PRO 8.3kJPN
chr19:55106177 		rs142517538
- 0.0206 -
19_GLY ARG 8.3kJPN
chr19:55106183 		-
- 0.0001 -
20_SER ILE 8.3kJPN
chr19:54783873 		-
- 0.0001 -
27_GLN TER 8.3kJPN
chr19:55143028 		-
- 0.0001 -
28_GLY ARG 8.3kJPN
chr19:55085848 		rs1290067922
- 0.0004 -
36_ARG HIS gnomAD
chr19:54783825 		rs141797988
- 0.000155165 -
36_ARG HIS gnomAD
chr19:55143056 		rs774715846
- 0.000115357 -
36_HIS ARG 8.3kJPN
chr19:55085873 		rs578056886
- 0.0001 -
36_ARG GLY 8.3kJPN
chr19:55143055 		rs749592435
- 0.0004 -
36_ARG HIS 8.3kJPN
chr19:55143056 		rs774715846
- 0.0001 -
38_TYR HIS 8.3kJPN
chr19:54783820 		-
- 0.0001 -
39_ARG LYS gnomAD
chr19:55085882 		rs543523193
- 0.000302235 -
40_GLU GLY gnomAD
chr19:55085885 		rs146935882
- 0.00133615 -
40_GLU GLN 8.3kJPN
chr19:55106246 		-
- 0.0001 -
45_LEU PRO gnomAD
chr19:54803621 		rs144909639
- 0.0215344 -
45_LEU PRO gnomAD
chr19:55143083 		rs1061679
- 0.393352 -
45_LEU PRO 8.3kJPN
chr19:54803621 		rs144909639
- 0.6753 -
46_TRP CYS gnomAD
chr19:55106266 		rs200632994
- 0.000318142 -
47_ILE PHE 8.3kJPN
chr19:54783793 		-
- 0.0001 -
49_ARG TRP gnomAD
chr19:55143094 		rs148931844
- 0.000839073 -
49_ARG GLN gnomAD
chr19:55143095 		rs202132279
- 0.00198433 -
50_ILE MET gnomAD
chr19:55085916 		rs543220734
- 0.000274398 -
50_ILE MET 8.3kJPN
chr19:55085916 		rs543220734
- 0.0001 -
51_ARG TER 8.3kJPN
chr19:54783781 		rs1366546333
- 0.0002 -
53_GLU LYS 8.3kJPN
chr19:55085920 		rs189159031
- 0.0001 -
54_ILE LEU 8.3kJPN
chr19:55106288 		rs147848714
- 0.0002 -
54_LEU ILE 8.3kJPN
chr19:55143109 		rs750501464
- 0.0003 -
60_PHE LEU 8.3kJPN
chr19:54803577 		rs200659644
- 0.003 -
61_PRO HIS gnomAD
chr19:55106310 		rs780771279
- 0.000107372 -
62_ILE THR gnomAD
chr19:55106313 		rs572192724
- 0.000349945 -
63_LEU PRO gnomAD
chr19:54803567 		rs142556784
- 0.0214898 -
63_PRO LEU gnomAD
chr19:55143137 		rs200880414
- 0.000178953 -
63_LEU PRO 8.3kJPN
chr19:54803567 		rs142556784
- 0.6751 -
64_SER CYS 8.3kJPN
chr19:55106319 		-
- 0.0001 -
67_TRP ARG gnomAD
chr19:55085962 		rs150302738
- 0.000250527 -
67_TRP GLY 8.3kJPN
chr19:54803556 		-
- 0.0001 -
68_GLU LYS 8.3kJPN
chr19:54783730 		rs1022457451
- 0.0004 -
70_ALA THR VAR_049888 rs12460501
Polymorphism - -
70_ALA THR gnomAD
chr19:55143157 		rs12460501
- 0.196584 -
70_THR ALA 8.3kJPN
chr19:55106336 		rs766834992
- 0.0001 -
71_GLY ALA gnomAD
chr19:55143161 		rs533376327
- 0.000222717 -
71_GLY GLU 8.3kJPN
chr19:55085975 		-
- 0.0001 -
72_ARG GLN gnomAD
chr19:54803540 		rs536143278
- 0.000175753 -
72_ARG TRP gnomAD
chr19:55143163 		rs147024305
- 0.000286337 -
72_ARG GLN gnomAD
chr19:55143164 		rs200251602
- 0.000369864 -
72_ARG TER 8.3kJPN
chr19:54783718 		rs746435174
- 0.0001 -
73_TYR CYS 8.3kJPN
chr19:55085981 		-
- 0.0004 -
74_ARG CYS 8.3kJPN
chr19:55106348 		rs780861027
- 0.0001 -
78_GLY SER gnomAD
chr19:55106360 		rs201715627
- 0.0031783 -
80_ASP HIS gnomAD
chr19:55143187 		rs61738512
- 0.00532668 -
81_ARG HIS gnomAD
chr19:54783693 		rs73055442
- 0.0296329 -
84_LEU ARG gnomAD
chr19:54803504 		rs6509862
- 0.248584 -
84_ARG CYS gnomAD
chr19:55143199 		rs138410838
- 0.00536037 -
84_LEU ARG 8.3kJPN
chr19:54803504 		rs6509862
- 0.9468 -
87_SER ARG gnomAD
chr19:55143208 		rs10418552
- 0.00536264 -
87_SER THR gnomAD
chr19:55143209 		rs10419085
- 0.00536366 -
87_SER ASN 8.3kJPN
chr19:55143209 		-
- 0.0001 -
89_ASP GLU gnomAD
chr19:55106395 		rs10417158
- 0.00523404 -
94_VAL MET 8.3kJPN
chr19:55106408 		rs1361562599
- 0.0001 -
95_VAL MET gnomAD
chr19:55086043 		rs138441532
- 0.00049387 -
98_ALA THR 8.3kJPN
chr19:55086200 		-
- 0.0001 -
100_ILE SER gnomAD
chr19:55143395 		rs370374304
- 0.000179349 -
100_SER ILE 8.3kJPN
chr19:54803309 		rs779366390
- 0.0003 -
106_ALA VAL 8.3kJPN
chr19:55086225 		-
- 0.0003 -
107_LEU GLN 8.3kJPN
chr19:54803288 		-
- 0.0003 -
107_LEU GLN 8.3kJPN
chr19:55086228 		rs780646104
- 0.0107 -
108_PRO SER 8.3kJPN
chr19:54803286 		-
- 0.002 -
110_PRO LEU 8.3kJPN
chr19:55086237 		-
- 0.0001 -
111_VAL MET 8.3kJPN
chr19:54783461 		-
- 0.0001 -
113_THR ALA 8.3kJPN
chr19:54783455 		rs768931745
- 0.005 -
113_THR ALA 8.3kJPN
chr19:54803271 		-
- 0.0003 -
113_THR ALA 8.3kJPN
chr19:55086245 		rs777235606
- 0.011 -
114_LEU SER gnomAD
chr19:55086249 		rs45523736
- 0.032222 -
114_SER LEU gnomAD
chr19:55106616 		rs138781448
- 0.00121317 -
114_SER THR 8.3kJPN
chr19:55086248 		-
- 0.0001 -
116_GLY ARG gnomAD
chr19:54803262 		rs150090129
- 0.000239905 -
116_GLY GLU 8.3kJPN
chr19:54803261 		rs751649447
- 0.0003 -
116_GLY GLU 8.3kJPN
chr19:55086255 		rs780649717
- 0.0112 -
116_GLY ARG 8.3kJPN
chr19:55106621 		-
- 0.0003 -
117_ARG THR 8.3kJPN
chr19:54783442 		rs749531977
- 0.0041 -
118_VAL MET 8.3kJPN
chr19:55106627 		rs1288597511
- 0.0001 -
119_THR ALA gnomAD
chr19:55086263 		rs75334515
- 0.000318127 -
119_ILE THR gnomAD
chr19:55143452 		rs1061680
- 0.35393 -
120_ILE LEU 8.3kJPN
chr19:54803250 		rs75159993
- 0.0003 -
123_GLU ASP 8.3kJPN
chr19:54783423 		rs758035729
- 0.0032 -
123_GLU GLY 8.3kJPN
chr19:54783424 		rs751291818
- 0.0033 -
123_ASP GLY 8.3kJPN
chr19:54803240 		-
- 0.0003 -
123_VAL GLY 8.3kJPN
chr19:55086276 		rs571423648
- 0.0112 -
125_GLN GLU 8.3kJPN
chr19:54803235 		-
- 0.0003 -
126_VAL LEU gnomAD
chr19:54803232 		rs141580607
- 0.000209601 -
126_VAL MET gnomAD
chr19:55106651 		rs150789645
- 0.000405634 -
126_VAL LEU 8.3kJPN
chr19:54803232 		rs141580607
- 0.0548 -
127_ALA PRO 8.3kJPN
chr19:54783413 		rs752410806
- 0.0027 -
127_ALA PRO 8.3kJPN
chr19:54803229 		-
- 0.0003 -
127_ALA PRO 8.3kJPN
chr19:55086287 		rs754386274
- 0.0107 -
128_PHE SER 8.3kJPN
chr19:54783409 		rs147946414
- 0.0001 -
129_GLY ASP 8.3kJPN
chr19:54783406 		rs201825609
- 0.003 -
130_GLY SER gnomAD
chr19:55086296 		rs73612414
- 0.00380153 -
130_SER GLY gnomAD
chr19:55106663 		rs10417589
- 0.106379 -
130_SER GLY 8.3kJPN
chr19:55106663 		rs10417589
- 0.0012 -
132_SER ILE gnomAD
chr19:55143491 		rs1061681
- 0.391419 -
136_GLU VAL gnomAD
chr19:54783385 		rs144777644
- 0.000636279 -
136_GLU GLN 8.3kJPN
chr19:54783386 		rs774796329
- 0.0033 -
136_GLU GLN 8.3kJPN
chr19:54803202 		-
- 0.0003 -
136_GLU GLN 8.3kJPN
chr19:55086314 		rs201199710
- 0.0087 -
137_GLY GLU 8.3kJPN
chr19:54783382 		rs763237443
- 0.0035 -
137_GLY GLU 8.3kJPN
chr19:54803198 		-
- 0.0003 -
137_GLY GLU 8.3kJPN
chr19:55086318 		rs981943540
- 0.0087 -
141_HIS GLN gnomAD
chr19:54803185 		rs201902629
- 0.000367911 -
141_HIS TYR gnomAD
chr19:55106696 		rs75416770
- 0.00308185 -
141_HIS TYR 8.3kJPN
chr19:55106696 		rs75416770
- 0.0517 -
143_GLN GLU 8.3kJPN
chr19:55143523 		rs763628392
- 0.0001 -
144_ARG CYS gnomAD
chr19:55086338 		rs149722559
- 0.0044498 -
144_ARG HIS gnomAD
chr19:55086339 		rs112235102
- 0.000850962 -
144_CYS ARG gnomAD
chr19:55143526 		rs528992461
- 0.000381743 -
144_ARG CYS 8.3kJPN
chr19:55086338 		rs149722559
- 0.007 -
145_LEU ARG gnomAD
chr19:55106709 		rs548810299
- 0.000198829 -
148_HIS GLN 8.3kJPN
chr19:55086352 		rs759834040
- 0.008 -
148_GLN HIS 8.3kJPN
chr19:55143540 		rs749158954
- 0.0003 -
149_SER PRO 8.3kJPN
chr19:55086353 		rs765734952
- 0.008 -
149_PRO SER 8.3kJPN
chr19:55143541 		rs768734027
- 0.0003 -
152_ARG HIS 8.3kJPN
chr19:54803153 		rs771007024
- 0.0003 -
154_SER TRP gnomAD
chr19:54783331 		rs576220286
- 0.000127629 -
154_SER TRP 8.3kJPN
chr19:54783331 		rs576220286
- 0.0016 -
154_SER ALA 8.3kJPN
chr19:54783332 		rs765998984
- 0.0011 -
154_TRP GLY 8.3kJPN
chr19:55086368 		rs780051526
- 0.0079 -
155_SER PRO 8.3kJPN
chr19:54783329 		rs555983101
- 0.0001 -
156_ARG GLN gnomAD
chr19:54803141 		rs147561158
- 0.000496601 -
156_ARG HIS 8.3kJPN
chr19:54783325 		rs765314039
- 0.0001 -
156_ARG CYS 8.3kJPN
chr19:54783326 		rs775954639
- 0.0011 -
156_TRP LEU 8.3kJPN
chr19:55086375 		rs1480552730
- 0.0001 -
156_ARG TRP 8.3kJPN
chr19:55106741 		rs201483250
- 0.0003 -
156_ARG GLN 8.3kJPN
chr19:55106742 		rs922288206
- 0.0001 -
161_VAL LEU 8.3kJPN
chr19:54783311 		-
- 0.0001 -
164_VAL MET gnomAD
chr19:55086398 		rs137946359
- 0.000314148 -
164_VAL MET gnomAD
chr19:55106765 		rs566667645
- 0.000560725 -
164_VAL MET 8.3kJPN
chr19:55106765 		rs566667645
- - -
166_PRO ALA gnomAD
chr19:55086404 		rs754870024
- 0.000135204 -
166_PRO LEU gnomAD
chr19:55086405 		rs74454618
- 0.000210761 -
166_PRO ARG 8.3kJPN
chr19:54783295 		rs752949543
- 0.0001 -
166_PRO ALA 8.3kJPN
chr19:55086404 		rs754870024
- 0.0011 -
166_PRO LEU 8.3kJPN
chr19:55106772 		rs202039753
- 0.0001 -
167_ASN SER gnomAD
chr19:54783292 		rs373341013
- 0.000187536 -
167_ASN SER 8.3kJPN
chr19:54783292 		rs373341013
- 0.001 -
168_ARG HIS gnomAD
chr19:55106778 		rs10418391
- 0.0655032 -
168_ARG HIS 8.3kJPN
chr19:55086411 		rs567633305
- - -
168_ARG CYS 8.3kJPN
chr19:55106777 		rs141328341
- 0.0001 -
168_ARG HIS 8.3kJPN
chr19:55106778 		rs10418391
- 0.0001 -
171_SER TRP gnomAD
chr19:54783280 		rs771929420
- 0.000127253 -
171_SER TRP gnomAD
chr19:55106787 		rs151320443
- 0.000696052 -
171_SER TRP 8.3kJPN
chr19:55086420 		rs770183945
- 0.0001 -
171_SER TER 8.3kJPN
chr19:55106787 		rs151320443
- - -
171_TRP TER 8.3kJPN
chr19:55143609 		rs373103118
- 0.0058 -
172_HIS TYR 8.3kJPN
chr19:54783278 		rs774001588
- 0.0005 -
175_TYR CYS 8.3kJPN
chr19:54783268 		-
- 0.0001 -
176_GLY ALA 8.3kJPN
chr19:54803081 		rs773860990
- 0.0004 -
176_ALA GLY 8.3kJPN
chr19:55086435 		rs138740762
- 0.0085 -
176_ALA GLY 8.3kJPN
chr19:55106802 		rs1339989721
- 0.0052 -
179_SER LEU gnomAD
chr19:55143632 		rs200423268
- 0.000349981 -
179_LEU SER 8.3kJPN
chr19:54783256 		rs374882341
- 0.0005 -
179_SER LEU 8.3kJPN
chr19:55143632 		rs200423268
- 0.0028 -
180_ARG HIS gnomAD
chr19:54803069 		rs147951028
- 0.0213833 -
180_ASN SER 8.3kJPN
chr19:54783253 		rs1189729658
- 0.0004 -
180_ARG HIS 8.3kJPN
chr19:54803069 		rs147951028
- 0.6756 -
180_ASN SER 8.3kJPN
chr19:55086447 		rs150674530
- 0.0085 -
180_ASN SER 8.3kJPN
chr19:55106814 		rs776711765
- 0.0053 -
181_SER THR 8.3kJPN
chr19:55106816 		-
- 0.0005 -
183_TYR CYS gnomAD
chr19:54783244 		rs201592158
- 0.00018299 -
183_TYR HIS gnomAD
chr19:55086455 		rs138719779
- 0.00196562 -
183_HIS TYR gnomAD
chr19:55106822 		rs150400481
- 0.00038646 -
183_TYR HIS 8.3kJPN
chr19:55086455 		rs138719779
- 0.0001 -
183_HIS TYR 8.3kJPN
chr19:55106822 		rs150400481
- 0.0054 -
185_TRP TER 8.3kJPN
chr19:55086463 		rs201934047
- 0.0033 -
186_SER PRO 8.3kJPN
chr19:55143652 		-
- 0.0002 -
187_LEU PRO gnomAD
chr19:55143656 		rs200859502
- 0.00019124 -
187_SER LEU 8.3kJPN
chr19:54783232 		rs200236517
- 0.0002 -
187_SER PRO 8.3kJPN
chr19:54783233 		rs201233860
- 0.0002 -
187_LEU VAL 8.3kJPN
chr19:55143655 		-
- 0.0001 -
190_ASP GLU 8.3kJPN
chr19:55086478 		rs752284633
- 0.0001 -
193_GLY GLU gnomAD
chr19:54803030 		rs142529349
- 0.0216022 -
193_GLY GLU 8.3kJPN
chr19:54803030 		rs142529349
- 0.6758 -
197_LEU PRO 8.3kJPN
chr19:55106865 		rs373854
- 0.3151 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.