PDB ID 1F42     CHAIN A
Protein name INTERLEUKIN-12 BETA CHAIN
Uniprot Accession P29460
The number of similar proteins 14
The number of binding states 9
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1F42 (CHAIN: A)
1 Monomeric state
2 Q9NPF7  
3 P29459  
4 Q9NPF7   3QWR  
5 Q9NPF7   Q9NPF7  
6 Q9NPF7   5MZV   Q5VWK5  
7 5NJD   5NJD   Q9NPF7  
8 3HMX   3HMX   P29459  
9 Q9NPF7   4GRW   4GRW   4GRW  

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Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   IWELKKDVYV   VELDWYPDAP   GEMVVLTCDT   PEEDGITWTL   DQSSEVLGSG   50
51   KTLTIQVKEF   GDAGQYTCHK   GGEVLSHSLL   LLHKKEDGIW   STDILKDQKE   100
101   PKNKTFLRCE   AKNYSGRFTC   WWLTTISTDL   TFSVKSSRGS   SDPQGVTCGA   150
151   ATLSAERVRG   DNKEYEYSVE   CQEDSACPAA   EESLPIEVMV   DAVHKLKYEN   200
201   YTSSFFIRDI   IKPDPPKNLQ   LKPLKNSRQV   EVSWEYPDTW   STPHSYFSLT   250
251   FCVQVQGKSK   REKKDRVFTD   KTSATVICRK   NASISVRAQD   RYYSSSWSEW   300
301   ASVPCS           350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
11_VAL ILE VAR_020001 rs3213096
Polymorphism - -
11_VAL ILE 4.7kJPN
chr5:158750329
rs3213096
- 0.0001 -
42_GLN HIS 4.7kJPN
chr5:158750234
-
- 0.0001 -
48_GLY SER 4.7kJPN
chr5:158750218
rs201684769
- 0.0001 -
56_GLN PRO 4.7kJPN
chr5:158750193
rs1361534479
- 0.0001 -
65_GLN TER ClinVar
chr5:158750167
-
Pathogenic - Immunodeficiency 29 [MedGen:C4013948,OMIM:614890,Orphanet:ORPHA319558]
87_ASP TYR 4.7kJPN
chr5:158750101
-
- 0.0001 -
93_ASP ASN 4.7kJPN
chr5:158750083
-
- 0.0002 -
102_LYS ARG 4.7kJPN
chr5:158749513
rs199703726
- 0.0009 -
147_THR LYS 4.7kJPN
chr5:158747505
-
- 0.0001 -
191_ASP ASN 4.7kJPN
chr5:158747374
-
- 0.0001 -
193_VAL ILE 4.7kJPN
chr5:158747368
rs79446920
- 0.0001 -
204_SER ASN 4.7kJPN
chr5:158747334
rs55661460
- 0.0378 -
276_VAL PHE VAR_049170 rs3213119
Polymorphism - -
291_ARG HIS 4.7kJPN
chr5:158743742
rs377524637
- 0.0001 -
294_SER GLY 4.7kJPN
chr5:158743734
-
- 0.0003 -
305_CYS TER 4.7kJPN
chr5:158743699
rs138991749
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.