PDB ID 1ES7     CHAIN A
Protein name BONE MORPHOGENETIC PROTEIN-2
Uniprot Accession P12643
The number of similar proteins 26
The number of binding states 10
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1ES7 (CHAIN: A)
1 P12643   P36894   P36894  
2 P12643  
3 Q6NW40  
4 P36894   P27038  
5 P12643   P36894  
6 P12643   Q96B86  
7 P12643   P36894   Q3KQI1  
8 P12643   Q5D734   Q5D734  
9 P12643   P36894   P36894   Q3KQI1  
10 P12643   Q6NW40   Q6NW40   P97798   P97798  

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Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MAQAKHKQRK   RLKSSCKRHP   LYVDFSDVGW   NDWIVAPPGY   HAFYCHGECP   50
51   FPLADHLNST   NHAIVQTLVN   SVNSKIPKAC   CVPTELSAIS   MLYLDENEKV   100
101   VLKNYQDMVV   EGCGCR         150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
15_ARG TRP 8.3kJPN
chr14:54417052 		rs745803587
- 0.0001 -
18_PRO THR 8.3kJPN
chr20:6759443 		rs1455627279
- 0.0001 -
47_CYS TER ClinVar
chr20:6759532 		rs1555786156
Pathogenic - SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES [MedGen:C4693481,OMIM:617877]
52_ALA VAL ClinVar
chr14:54416940 		rs121912766
Pathogenic - Orofacial cleft 11 [MedGen:C2677434,OMIM:600625]
65_THR MET gnomAD
chr20:6759585 		rs148745143
- 0.000190929 -
73_SER ILE 8.3kJPN
chr14:54416877 		-
- 0.0001 -
74_ILE VAL 8.3kJPN
chr20:6759611 		-
- 0.0001 -
93_ASP GLU 8.3kJPN
chr20:6759670 		-
- 0.0001 -
105_ASP GLY VAR_052570 rs11545591
Polymorphism - -
114_ARG HIS gnomAD
chr20:6759732 		rs151019338
- 0.000169598 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.