PDB ID 1EJL     CHAIN I
Protein name IMPORTIN ALPHA
Uniprot Accession P52293
The number of similar proteins 149
The number of binding states 25
The number of binding partners 24

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   NQGTVNWSVE   DIVKGINSNN   LESQLQATQA   ARKLLSREKQ   PPIDNIIRAG   50
51   LIPKFVSFLG   KTDCSPIQFE   SAWALTNIAS   GTSEQTKAVV   DGGAIPAFIS   100
101   LLASPHAHIS   EQAVWALGNI   AGDGSAFRDL   VIKHGAIDPL   LALLAVPDLS   150
151   TLACGYLRNL   TWTLSNLCRN   KNPAPPLDAV   EQILPTLVRL   LHHNDPEVLA   200
201   DSCWAISYLT   DGPNERIEMV   VKKGVVPQLV   KLLGATELPI   VTPALRAIGN   250
251   IVTGTDEQTQ   KVIDAGALAV   FPSLLTNPKT   NIQKEATWTM   SNITAGRQDQ   300
301   IQQVVNHGLV   PFLVGVLSKA   DFKTQKEAAW   AITNYTSGGT   VEQIVYLVHC   350
351   GIIEPLMNLL   SAKDTKIIQV   ILDAISNIFQ   AAEKLGETEK   LSIMIEECGG   400
401   LDKIEALQRH   ENESVYKASL   NLIEKYFSVE   EEEDQNVVPE   TTSEGFAFQV   450
451   QDGAPGTFNF           500

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
86_ASN SER gnomAD
chr17:66036837
rs142064368
- 0.000274424 -
99_ALA GLY 8.3kJPN
chr17:66036876
rs782062469
- 0.0001 -
114_ASN LYS 8.3kJPN
chr17:66038240
-
- 0.0002 -
117_ARG TRP gnomAD
chr17:66038247
rs144637470
- 0.00221403 -
117_ARG GLN gnomAD
chr17:66038248
rs148032855
- 0.00119055 -
132_ASP TYR 8.3kJPN
chr17:66038292
-
- 0.0001 -
155_THR SER 8.3kJPN
chr17:66038362
rs142601381
- 0.0004 -
165_PRO ARG gnomAD
chr17:66038392
rs11545989
- 0.0036701 -
173_SER TYR 8.3kJPN
chr17:66038416
-
- 0.0001 -
183_VAL PHE 8.3kJPN
chr17:66038445
-
- 0.0002 -
194_SER LEU 8.3kJPN
chr17:66039030
rs1568276940
- 0.0001 -
216_PRO SER gnomAD
chr17:66039095
rs11545988
- 0.00218697 -
218_MET THR gnomAD
chr17:66039102
rs142968438
- 0.000278346 -
227_ARG CYS 8.3kJPN
chr17:66039228
rs782396125
- 0.0001 -
244_PRO THR gnomAD
chr17:66039279
rs146139322
- 0.000409869 -
244_PRO SER 8.3kJPN
chr17:66039279
rs146139322
- 0.0001 -
246_ILE LEU 8.3kJPN
chr17:66039285
-
- 0.0001 -
255_THR SER gnomAD
chr17:66039312
rs140011802
- 0.000119331 -
263_ASP ALA gnomAD
chr17:66039337
rs556496043
- 0.000186892 -
285_ARG GLN gnomAD
chr17:66039403
rs781877143
- 0.000131216 -
285_ARG GLN 8.3kJPN
chr17:66039403
rs781877143
- 0.0016 -
329_GLN TER 8.3kJPN
chr17:66040008
-
- 0.0001 -
334_ALA VAL 8.3kJPN
chr17:66040024
-
- 0.0001 -
350_ASN ASP 8.3kJPN
chr17:66040071
-
- 0.0001 -
356_THR MET gnomAD
chr17:66040090
rs138064111
- 0.000358226 -
356_THR MET 8.3kJPN
chr17:66040090
rs138064111
- 0.0034 -
366_ARG CYS gnomAD
chr17:66040119
rs202041693
- 0.00017513 -
366_ARG CYS 8.3kJPN
chr17:66040119
rs202041693
- 0.0011 -
465_GLU ALA 8.3kJPN
chr17:66041934
-
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.