PDB ID 1EBA     CHAIN A
Protein name PROTEIN (ERYTHROPOIETIN RECEPTOR)
Uniprot Accession P19235
The number of similar proteins 25
The number of binding states 9
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1EBA (CHAIN: A)
1 P19235  
2 6MOE  
3 6MOL  
4 P01588  
5 2JIX   2JIX  
6 4Y5V   4Y5V  
7 P19235   6MOH  
8 P19235   P01588  
9 P19235   4Y5X   Q5NV67  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   KFESKAALLA   ARGPEELLCF   TERLEDLVCF   WEEAASAGVG   PGNYSFSYQL   50
51   EDEPWKLCRL   HQAPTARGAV   RFWCSLPTAD   TSSFVPLELR   VTAASGAPRY   100
101   HRVIHINEVV   LLDAPVGLVA   RLADESGHVV   LRWLPPPETP   MTSHIRYEVD   150
151   VSAGNGAGSV   QRVEILEGRT   ECVLSNLRGR   TRYTFAVRAR   MAEPSFGGFW   200
201   SAWSEPVSLL   TPSDL         250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
21_ARG TRP 8.3kJPN
chr19:11493891 		rs751506215
- 0.0001 -
22_GLY GLU gnomAD
chr19:11493887 		rs45516306
- 0.00549587 -
41_GLU LYS 8.3kJPN
chr19:11493831 		-
- 0.0001 -
48_VAL ALA 8.3kJPN
chr19:11493809 		rs780617943
- 0.0001 -
54_SER THR gnomAD
chr19:11493791 		rs140267472
- 0.00018756 -
58_GLN TER ClinVar
chr19:11493780 		rs370865377
Likely pathogenic - not provided [MedGen:CN517202]
58_GLN ARG 8.3kJPN
chr19:11493779 		rs1218322679
- 0.0001 -
68_ARG PRO 8.3kJPN
chr19:11492758 		-
- 0.0001 -
75_ALA VAL gnomAD
chr19:11492737 		rs146235694
- 0.000929413 -
99_ARG SER 8.3kJPN
chr19:11492666 		-
- 0.0001 -
113_ILE VAL 8.3kJPN
chr19:11492624 		-
- 0.0001 -
125_VAL MET 8.3kJPN
chr19:11492508 		rs1206410452
- 0.0001 -
129_ALA VAL 8.3kJPN
chr19:11492495 		rs758156767
- 0.0001 -
132_ALA VAL 8.3kJPN
chr19:11492486 		-
- 0.0002 -
138_VAL ILE 8.3kJPN
chr19:11492469 		-
- 0.0001 -
158_VAL LEU 8.3kJPN
chr19:11492409 		rs1326443454
- 0.0001 -
160_VAL ILE 8.3kJPN
chr19:11492403 		-
- 0.0001 -
175_LEU PRO gnomAD
chr19:11491875 		rs750657898
- 0.00020678 -
179_THR ALA 8.3kJPN
chr19:11491864 		-
- 0.0001 -
180_GLU ASP 8.3kJPN
chr19:11491859 		-
- 0.0001 -
188_GLY CYS 8.3kJPN
chr19:11491837 		rs185740642
- 0.0069 -
201_ALA VAL 8.3kJPN
chr19:11491797 		-
- 0.0001 -
209_TRP GLY gnomAD
chr19:11491774 		rs773564773
- 0.00016984 -
215_PRO THR 8.3kJPN
chr19:11491756 		rs765522005
- 0.0021 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.