PDB ID 1CX8     CHAIN A
Protein name TRANSFERRIN RECEPTOR PROTEIN
Uniprot Accession P02786
The number of similar proteins 16
The number of binding states 8
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1CX8 (CHAIN: A)
1 P02786  
2 P02787  
3 Q8AZ57  
4 6OKD  
5 6WRV  
6 P02786   6WRW  
7 P02786   Q30201   Q30201  
8 P02786   6WRV   6WRV  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   LYWDDLKRKL   SEKLDSTDFT   STIKLLNENS   YVPREAGSQK   DENLALYVEN   50
51   EFREFKLSKV   WRDQHFVKIQ   VKDSAQNSVI   IVDKNGRLVY   LVENPGGYVA   100
101   YSKAATVTGK   LVHANFGTKK   DFEDLYTPVN   GSIVIVRAGK   ITFAEKVANA   150
151   ESLNAIGVLI   YMDQTKFPIV   NAELSFFGHA   HLGTGDPYTP   GFPSFNHTQF   200
201   PPSRSSGLPN   IPVQTISRAA   AEKLFGNMEG   DCPSDWKTDS   TCRMVTSESK   250
251   NVKLTVSNVL   KEIKILNIFG   VIKGFVEPDH   YVVVGAQRDA   WGPGAAKSGV   300
301   GTALLLKLAQ   MFSDMVLKDG   FQPSRSIIFA   SWSAGDFGSV   GATEWLEGYL   350
351   SSLHLKAFTY   INLDKAVLGT   SNFKVSASPL   LYTLIEKTMQ   NVKHPVTGQF   400
401   LYQDSNWASK   VEKLTLDNAA   FPFLAYSGIP   AVSFCFCEDT   DYPYLGTTMD   450
451   TYKELIERIP   ELNKVARAAA   EVAGQFVIKL   THDVELNLDY   EEYNSQLLSF   500
501   VRDLNQYRAD   IKEMGLSLQW   LYSARGDFFR   ATSRLTTDFG   NAEKTDRFVM   550
551   KKLNDRVMRV   EYHFLSPYVS   PKESPFRHVF   WGSGSHTLPA   LLENLKLRKQ   600
601   NNGAFNETLF   RNQLALATWT   IQGAANALSG   DVWDIDNEF     650

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
132_SER LEU 8.3kJPN
chr3:195800840 		rs370784605
- 0.0001 -
142_GLY SER gnomAD
chr3:195800811 		rs3817672
- 0.449417 -
142_GLY SER 8.3kJPN
chr3:195800811 		rs3817672
- 0.2078 -
160_GLN ARG 8.3kJPN
chr3:195798979 		-
- 0.0001 -
166_ALA VAL 8.3kJPN
chr3:195798961 		rs771569167
- 0.0001 -
183_ARG HIS 8.3kJPN
chr3:195798910 		rs778329855
- 0.0002 -
212_LEU VAL VAR_051806 rs41301381
LB/B - -
212_LEU VAL gnomAD
chr3:195798320 		rs41301381
- 0.00196839 -
212_LEU VAL 8.3kJPN
chr3:195798320 		rs41301381
- 0.0254 -
221_ALA VAL 8.3kJPN
chr3:195798292 		rs754768415
- 0.0002 -
230_GLY SER 8.3kJPN
chr3:195796439 		-
- 0.0001 -
248_THR ILE 8.3kJPN
chr3:195796384 		rs762642181
- 0.0011 -
277_ILE VAL 8.3kJPN
chr3:195794974 		rs533268185
- 0.0001 -
293_ALA THR 8.3kJPN
chr3:195794926 		rs541398971
- 0.0001 -
296_SER PRO 8.3kJPN
chr3:195794917 		rs1310686971
- 0.0001 -
303_LEU ARG 8.3kJPN
chr3:195794521 		-
- 0.0002 -
337_ILE VAL gnomAD
chr3:195794420 		rs41295849
- 0.000437975 -
337_ILE VAL 8.3kJPN
chr3:195794420 		rs41295849
- 0.0004 -
352_ASP GLY gnomAD
chr3:195792457 		rs140316777
- 0.00033598 -
362_THR ALA 8.3kJPN
chr3:195792428 		-
- 0.0001 -
376_THR ASN 8.3kJPN
chr3:195792385 		rs760283092
- 0.0005 -
379_ASN SER gnomAD
chr3:195792376 		rs539830157
- 0.000184735 -
407_ALA THR gnomAD
chr3:195791279 		rs184956956
- 0.00030189 -
420_GLY SER VAR_051807 rs41295879
LB/B - -
420_GLY SER gnomAD
chr3:195791240 		rs41295879
- 0.00236663 -
495_LYS ARG 8.3kJPN
chr3:195787103 		rs765448251
- 0.0002 -
564_PRO SER gnomAD
chr3:195782160 		rs571673598
- 0.000182924 -
569_THR SER 8.3kJPN
chr3:195782144 		rs757696465
- 0.0001 -
588_ARG GLN 8.3kJPN
chr3:195782087 		rs754713292
- 0.0012 -
598_VAL MET gnomAD
chr3:195782058 		rs144131234
- 0.00010736 -
651_ARG HIS 8.3kJPN
chr3:195780377 		-
- 0.0001 -
669_PHE TYR 8.3kJPN
chr3:195780323 		-
- 0.0001 -
677_ARG HIS VAR_051808 rs41298067
LB/B - -
679_MET LYS 8.3kJPN
chr3:195780293 		-
- 0.0001 -
693_LYS ARG 8.3kJPN
chr3:195779018 		rs770731307
- 0.0001 -
696_PRO ARG 8.3kJPN
chr3:195779009 		-
- 0.0001 -
706_SER PRO 8.3kJPN
chr3:195778980 		-
- 0.0001 -
719_ARG CYS 8.3kJPN
chr3:195778941 		rs764730449
- 0.0005 -
729_THR MET gnomAD
chr3:195778910 		rs202242239
- 0.000250523 -
729_THR MET 8.3kJPN
chr3:195778910 		rs202242239
- 0.0005 -
753_VAL ILE gnomAD
chr3:195778839 		rs141165322
- 0.000206815 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.