PDB ID 1CX8     CHAIN A
Protein name TRANSFERRIN RECEPTOR PROTEIN
Uniprot Accession P02786
The number of similar proteins 8
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1CX8 (CHAIN: A)
1 P02786  
2 P02786   P02787  
3 P02786   Q8AZ57  
4 P02786   Q30201   Q30201  

Downdload

Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   LYWDDLKRKL   SEKLDSTDFT   STIKLLNENS   YVPREAGSQK   DENLALYVEN   50
51   EFREFKLSKV   WRDQHFVKIQ   VKDSAQNSVI   IVDKNGRLVY   LVENPGGYVA   100
101   YSKAATVTGK   LVHANFGTKK   DFEDLYTPVN   GSIVIVRAGK   ITFAEKVANA   150
151   ESLNAIGVLI   YMDQTKFPIV   NAELSFFGHA   HLGTGDPYTP   GFPSFNHTQF   200
201   PPSRSSGLPN   IPVQTISRAA   AEKLFGNMEG   DCPSDWKTDS   TCRMVTSESK   250
251   NVKLTVSNVL   KEIKILNIFG   VIKGFVEPDH   YVVVGAQRDA   WGPGAAKSGV   300
301   GTALLLKLAQ   MFSDMVLKDG   FQPSRSIIFA   SWSAGDFGSV   GATEWLEGYL   350
351   SSLHLKAFTY   INLDKAVLGT   SNFKVSASPL   LYTLIEKTMQ   NVKHPVTGQF   400
401   LYQDSNWASK   VEKLTLDNAA   FPFLAYSGIP   AVSFCFCEDT   DYPYLGTTMD   450
451   TYKELIERIP   ELNKVARAAA   EVAGQFVIKL   THDVELNLDY   EEYNSQLLSF   500
501   VRDLNQYRAD   IKEMGLSLQW   LYSARGDFFR   ATSRLTTDFG   NAEKTDRFVM   550
551   KKLNDRVMRV   EYHFLSPYVS   PKESPFRHVF   WGSGSHTLPA   LLENLKLRKQ   600
601   NNGAFNETLF   RNQLALATWT   IQGAANALSG   DVWDIDNEF     650

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
142_GLY SER 4.7kJPN
chr3:195800811
rs3817672
- 0.2062 -
160_GLN ARG 4.7kJPN
chr3:195798979
-
- 0.0001 -
183_ARG HIS 4.7kJPN
chr3:195798910
rs778329855
- 0.0001 -
212_LEU VAL VAR_051806 rs41301381
Polymorphism - -
212_LEU VAL 4.7kJPN
chr3:195798320
rs41301381
- 0.0256 -
221_ALA VAL 4.7kJPN
chr3:195798292
rs754768415
- 0.0002 -
248_THR ILE 4.7kJPN
chr3:195796384
rs762642181
- 0.0013 -
277_ILE VAL 4.7kJPN
chr3:195794974
rs533268185
- 0.0001 -
293_ALA THR 4.7kJPN
chr3:195794926
rs541398971
- 0.0001 -
296_SER PRO 4.7kJPN
chr3:195794917
rs1310686971
- 0.0001 -
303_LEU ARG 4.7kJPN
chr3:195794521
-
- 0.0001 -
337_ILE VAL 4.7kJPN
chr3:195794420
rs41295849
- 0.0003 -
376_THR ASN 4.7kJPN
chr3:195792385
rs760283092
- 0.0006 -
420_GLY SER VAR_051807 rs41295879
Polymorphism - -
495_LYS ARG 4.7kJPN
chr3:195787103
rs765448251
- 0.0003 -
588_ARG GLN 4.7kJPN
chr3:195782087
rs754713292
- 0.001 -
651_ARG HIS 4.7kJPN
chr3:195780377
-
- 0.0001 -
669_PHE TYR 4.7kJPN
chr3:195780323
-
- 0.0001 -
677_ARG HIS VAR_051808 rs41298067
Polymorphism - -
679_MET LYS 4.7kJPN
chr3:195780293
-
- 0.0001 -
696_PRO ARG 4.7kJPN
chr3:195779009
-
- 0.0001 -
706_SER PRO 4.7kJPN
chr3:195778980
-
- 0.0001 -
719_ARG CYS 4.7kJPN
chr3:195778941
rs764730449
- 0.0004 -
729_THR MET 4.7kJPN
chr3:195778910
rs202242239
- 0.0004 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.