PDB ID 1BVN     CHAIN P
Protein name PROTEIN (ALPHA-AMYLASE)
Uniprot Accession P00690
The number of similar proteins 17
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1BVN (CHAIN: P)
1 P01092  
2 Monomeric state
3 4X0N  
4 1KXT  
5 P02873  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   QYAPQTQSGR   TDIVHLFEWR   WVDIALECER   YLGPKGFGGV   QVSPPNENVV   50
51   VTNPSRPWWE   RYQPVSYKLC   TRSGNENEFR   DMVTRCNNVG   VRIYVDAVIN   100
101   HMCGSGAAAG   TGTTCGSYCN   PGSREFPAVP   YSAWDFNDGK   CKTASGGIES   150
151   YNDPYQVRDC   QLVGLLDLAL   EKDYVRSMIA   DYLNKLIDIG   VAGFRLDASK   200
201   HMWPGDIKAV   LDKLHNLNTN   WFPAGSRPFI   FQEVIDLGGE   AISSSEYFGN   250
251   GRVTEFKYGA   KLGTVVRKWS   GEKMSYLKNW   GEGWGFMPSD   RALVFVDNHD   300
301   NQRGHGAGGS   SILTFWDARL   YKVAVGFMLA   HPYGFTRVMS   SYRWARNFVN   350
351   GEDVNDWIGP   PNNNGVIKEV   TINADTTCGN   DWVCEHRWRE   IRNMVWFRNV   400
401   VDGQPFANWW   DNGSNQVAFG   RGNRGFIVFN   NDDWQLSSTL   QTGLPGGTYC   450
451   NVISGDKVGN   SCTGIKVYVS   SDGTAQFSIS   NSAQDPFIAI   HAESKL   500

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
4_PRO SER 8.3kJPN
chr1:104160117
rs777629405
- 0.0001 -
10_ARG TRP gnomAD
chr1:104114297
rs146354476
- 0.000104112 -
10_ARG GLN gnomAD
chr1:104114298
rs139632093
- 0.000992341 -
10_ARG TRP gnomAD
chr1:104160135
rs145483775
- 0.000120228 -
20_ARG TER 8.3kJPN
chr1:104114327
rs761465185
- 0.0001 -
20_ARG GLN 8.3kJPN
chr1:104160166
-
- 0.0002 -
22_VAL GLY 8.3kJPN
chr1:104114334
-
- 0.0001 -
23_ASP ASN 8.3kJPN
chr1:104160174
rs754651162
- 0.0001 -
27_GLU GLN 8.3kJPN
chr1:104114348
-
- 0.0001 -
30_ARG GLN 8.3kJPN
chr1:104114358
rs558718174
- 0.0002 -
30_ARG GLN 8.3kJPN
chr1:104160196
rs148507365
- 0.0001 -
30_ARG TER 8.3kJPN
chr1:104293224
rs1350376061
- 0.0001 -
31_TYR CYS 8.3kJPN
chr1:104160199
-
- 0.0001 -
33_ALA THR 8.3kJPN
chr1:104160204
rs79714993
- 0.0001 -
34_PRO THR gnomAD
chr1:104160207
rs147709536
- 0.000144051 -
34_PRO ALA gnomAD
chr1:104160207
rs147709536
- 0.000332117 -
35_LYS GLN 8.3kJPN
chr1:104160210
rs773791633
- 0.0002 -
41_GLN HIS 8.3kJPN
chr1:104114392
-
- 0.0001 -
43_SER PRO gnomAD
chr1:104114735
rs746610299
- 0.000107593 -
50_ALA THR gnomAD
chr1:104160600
rs565929673
- 0.000184038 -
52_TYR HIS gnomAD
chr1:104160606
rs772378904
- 0.000132051 -
52_HIS TYR 8.3kJPN
chr1:104114762
rs763891745
- 0.0001 -
59_TRP TER 8.3kJPN
chr1:104114784
-
- 0.0001 -
60_GLU TER 8.3kJPN
chr1:104114786
-
- 0.0001 -
64_PRO ARG 8.3kJPN
chr1:104114799
rs758698996
- 0.0001 -
69_LEU PHE 8.3kJPN
chr1:104114815
rs1226144068
- 0.0001 -
70_CYS ARG 8.3kJPN
chr1:104114816
-
- 0.0001 -
80_ARG SER gnomAD
chr1:104160692
rs201971373
- 0.000337027 -
80_ARG SER 8.3kJPN
chr1:104160692
rs201971373
- 0.0096 -
84_THR ASN gnomAD
chr1:104160703
rs143462563
- 0.00274138 -
84_THR ASN 8.3kJPN
chr1:104160703
rs143462563
- 0.0016 -
89_VAL ILE 8.3kJPN
chr1:104114873
rs766776510
- 0.0004 -
92_ARG HIS gnomAD
chr1:104161537
rs543952790
- 0.000243595 -
92_ARG CYS 8.3kJPN
chr1:104115688
rs750106406
- 0.0001 -
92_ARG CYS 8.3kJPN
chr1:104161536
rs770671951
- 0.0002 -
97_ALA THR 8.3kJPN
chr1:104115703
rs528267080
- - -
103_SER CYS 8.3kJPN
chr1:104115722
rs4098273
- 0.0001 -
103_CYS SER 8.3kJPN
chr1:104161570
rs1327917758
- 0.0001 -
105_ASN ILE 8.3kJPN
chr1:104161576
-
- 0.0001 -
107_VAL MET 8.3kJPN
chr1:104115733
-
- 0.0001 -
108_SER ARG 8.3kJPN
chr1:104161586
rs1390018344
- 0.0001 -
109_ALA SER 8.3kJPN
chr1:104115739
-
- 0.0001 -
113_SER ILE 8.3kJPN
chr1:104161600
-
- 0.0001 -
123_SER ILE 8.3kJPN
chr1:104115782
-
- 0.0001 -
123_SER ASN 8.3kJPN
chr1:104161630
rs560183547
- 0.0007 -
130_PRO SER gnomAD
chr1:104161650
rs200536753
- 0.00689471 -
148_ILE VAL 8.3kJPN
chr1:104161704
rs1319186352
- 0.0001 -
157_VAL PHE 8.3kJPN
chr1:104162176
rs1276826607
- 0.0001 -
159_ASP TYR 8.3kJPN
chr1:104162182
-
- 0.0001 -
159_ASP GLU 8.3kJPN
chr1:104162184
rs748793710
- 0.0048 -
161_ARG HIS gnomAD
chr1:104116343
rs144281226
- 0.000119487 -
161_ARG HIS gnomAD
chr1:104162189
rs200283230
- 0.000225717 -
161_ARG HIS 8.3kJPN
chr1:104162189
rs200283230
- 0.0001 -
163_THR SER gnomAD
chr1:104162194
rs1143394
- 0.0152673 -
166_LEU PRO 8.3kJPN
chr1:104116358
rs1439427166
- 0.0001 -
173_ASP VAL 8.3kJPN
chr1:104162225
-
- 0.0001 -
174_TYR HIS gnomAD
chr1:104116381
rs201095914
- 0.000613209 -
176_ARG HIS gnomAD
chr1:104116388
rs370144544
- 0.000103535 -
176_ARG HIS gnomAD
chr1:104162234
rs764700031
- 0.000194656 -
176_ARG HIS 8.3kJPN
chr1:104116388
rs370144544
- 0.0001 -
176_ARG CYS 8.3kJPN
chr1:104162233
rs763068700
- 0.0002 -
176_ARG HIS 8.3kJPN
chr1:104162234
rs764700031
- 0.0001 -
178_LYS MET gnomAD
chr1:104162240
rs559702141
- 0.00100575 -
179_ILE MET gnomAD
chr1:104116398
rs770310222
- 0.000131403 -
181_GLU LYS gnomAD
chr1:104116402
rs200162760
- 0.000211041 -
182_TYR HIS 8.3kJPN
chr1:104116405
rs1248882715
- 0.0001 -
186_LEU PHE gnomAD
chr1:104162263
rs546094070
- 0.000120942 -
186_LEU VAL 8.3kJPN
chr1:104162263
rs546094070
- 0.0001 -
189_ILE THR 8.3kJPN
chr1:104162273
rs1247561853
- 0.0001 -
190_GLY SER gnomAD
chr1:104162275
rs149883399
- 0.00203761 -
191_VAL ALA 8.3kJPN
chr1:104162279
-
- 0.0002 -
195_ARG GLY gnomAD
chr1:104162290
rs531383627
- 0.000171412 -
196_LEU ILE 8.3kJPN
chr1:104162293
rs549614263
- 0.0001 -
201_HIS LEU 8.3kJPN
chr1:104162309
rs200197467
- 0.0011 -
203_TRP ARG gnomAD
chr1:104162314
rs762269432
- 0.000186309 -
208_LYS GLN 8.3kJPN
chr1:104116483
-
- 0.0003 -
215_HIS ARG gnomAD
chr1:104162351
rs140204075
- 0.0146323 -
217_LEU VAL 8.3kJPN
chr1:104162356
-
- 0.0001 -
222_PHE TYR 8.3kJPN
chr1:104116526
-
- 0.0001 -
228_PRO HIS gnomAD
chr1:104116544
rs137860562
- 0.00033871 -
231_TYR PHE 8.3kJPN
chr1:104116553
-
- 0.0001 -
238_GLY SER gnomAD
chr1:104163185
rs142529431
- 0.000415795 -
238_GLY VAL 8.3kJPN
chr1:104163186
rs532919677
- 0.0005 -
244_SER ASN 8.3kJPN
chr1:104116913
-
- 0.0001 -
248_PHE LEU 8.3kJPN
chr1:104163217
-
- 0.0001 -
263_GLY SER 8.3kJPN
chr1:104116969
rs764566458
- 0.0001 -
263_GLY SER 8.3kJPN
chr1:104163260
rs746422923
- 0.0001 -
265_VAL ILE 8.3kJPN
chr1:104163266
rs61814453
- 0.113 -
267_ARG HIS gnomAD
chr1:104163273
rs200554552
- 0.00151533 -
267_ARG CYS 8.3kJPN
chr1:104116981
rs368462934
- 0.0001 -
267_ARG HIS 8.3kJPN
chr1:104163273
rs200554552
- 0.03 -
268_LYS GLU 8.3kJPN
chr1:104163275
-
- 0.0002 -
270_ASN SER 8.3kJPN
chr1:104116991
rs752838004
- 0.0001 -
274_MET ILE gnomAD
chr1:104117004
rs147458656
- 0.00025118 -
278_LYS GLU 8.3kJPN
chr1:104117014
-
- 0.0001 -
281_GLY ARG gnomAD
chr1:104117852
rs147215616
- 0.00219045 -
281_GLY GLU gnomAD
chr1:104117853
rs544350905
- 0.000211073 -
282_GLU LYS gnomAD
chr1:104117855
rs755587777
- 0.000103545 -
285_GLY SER gnomAD
chr1:104234213
rs748941669
- 0.000144774 -
287_MET THR 8.3kJPN
chr1:104117871
-
- 0.0001 -
288_PRO LEU 8.3kJPN
chr1:104203011
rs779901818
- 0.0001 -
289_SER CYS 8.3kJPN
chr1:104234200
-
- 0.0001 -
292_ALA VAL gnomAD
chr1:104203023
rs201288184
- 0.00236711 -
292_ALA VAL gnomAD
chr1:104234191
rs201627077
- 0.0018816 -
292_ALA VAL gnomAD
chr1:104297162
rs201967863
- 0.000102512 -
292_ALA VAL 8.3kJPN
chr1:104234191
rs201627077
- 0.0161 -
292_ALA VAL 8.3kJPN
chr1:104297162
rs201967863
- 0.0001 -
293_LEU PHE 8.3kJPN
chr1:104234189
rs757768134
- 0.0007 -
294_VAL ALA gnomAD
chr1:104117892
rs140209167
- 0.0023334 -
296_VAL GLU gnomAD
chr1:104234179
rs549527747
- 0.00112844 -
297_ASP TYR 8.3kJPN
chr1:104117900
rs1329718469
- 0.0001 -
297_ASP ASN 8.3kJPN
chr1:104234177
-
- 0.0001 -
298_ASN ILE gnomAD
chr1:104203041
rs150405191
- 0.000513367 -
300_ASP GLU 8.3kJPN
chr1:104234166
-
- 0.0001 -
300_ASP VAL 8.3kJPN
chr1:104234167
-
- 0.0001 -
301_ASN SER 8.3kJPN
chr1:104234164
rs763143822
- 0.0003 -
303_ARG TER 8.3kJPN
chr1:104203055
rs367719363
- 0.0001 -
303_ARG TER 8.3kJPN
chr1:104297194
rs752371105
- 0.0011 -
304_GLY ARG gnomAD
chr1:104117921
rs140978983
- 0.0233147 -
306_GLY ALA gnomAD
chr1:104297204
rs779977255
- 0.000110009 -
306_GLY TRP 8.3kJPN
chr1:104117927
rs1263496927
- 0.0004 -
307_ALA THR gnomAD
chr1:104234147
rs140294416
- 0.000532077 -
307_ALA THR gnomAD
chr1:104297206
rs139911862
- 0.000276823 -
307_ALA THR 8.3kJPN
chr1:104203067
rs755582791
- 0.0008 -
307_ALA THR 8.3kJPN
chr1:104234147
rs140294416
- 0.0001 -
309_GLY GLU 8.3kJPN
chr1:104297213
rs775987541
- 0.0005 -
310_ALA VAL gnomAD
chr1:104234137
rs545069888
- 0.000144994 -
310_ALA VAL 8.3kJPN
chr1:104203077
-
- 0.0001 -
310_ALA VAL 8.3kJPN
chr1:104234137
rs545069888
- 0.0001 -
311_SER CYS 8.3kJPN
chr1:104234134
-
- 0.0001 -
313_LEU ILE gnomAD
chr1:104203085
rs781432273
- 0.000236269 -
313_LEU ILE gnomAD
chr1:104234129
rs577689111
- 0.000110579 -
313_LEU VAL gnomAD
chr1:104297224
rs145792361
- 0.00087233 -
313_LEU ARG 8.3kJPN
chr1:104234128
rs758357562
- 0.001 -
318_ALA THR gnomAD
chr1:104297239
rs144288724
- 0.000650053 -
318_ALA VAL 8.3kJPN
chr1:104234113
rs765307647
- 0.0001 -
323_MET ILE 8.3kJPN
chr1:104297349
rs757607457
- 0.0001 -
327_PHE CYS 8.3kJPN
chr1:104203222
-
- 0.0001 -
337_ARG TER 8.3kJPN
chr1:104118115
rs760449208
- 0.0001 -
337_ARG TER 8.3kJPN
chr1:104233963
rs199554865
- 0.0007 -
337_ARG TER 8.3kJPN
chr1:104297389
rs140363602
- 0.0001 -
342_TYR TER 8.3kJPN
chr1:104118132
-
- 0.0001 -
343_ARG HIS gnomAD
chr1:104118134
rs150608402
- 0.000210991 -
343_ARG HIS gnomAD
chr1:104203270
rs747319728
- 0.00014273 -
343_ARG HIS gnomAD
chr1:104297408
rs748837763
- 0.000135517 -
343_ARG HIS 8.3kJPN
chr1:104118134
rs150608402
- 0.0001 -
343_ARG CYS 8.3kJPN
chr1:104203269
-
- 0.0001 -
343_ARG HIS 8.3kJPN
chr1:104203270
rs747319728
- 0.0001 -
343_ARG HIS 8.3kJPN
chr1:104233944
rs541141393
- 0.0002 -
343_ARG CYS 8.3kJPN
chr1:104297407
rs779804656
- 0.0002 -
343_ARG HIS 8.3kJPN
chr1:104297408
rs748837763
- 0.0001 -
346_ARG THR 8.3kJPN
chr1:104118143
rs1171955418
- 0.0004 -
349_GLU ALA gnomAD
chr1:104203288
rs554343114
- 0.000179817 -
349_GLU ALA gnomAD
chr1:104233926
rs754163001
- 0.000475111 -
352_ASN SER 8.3kJPN
chr1:104118161
rs572909605
- 0.0001 -
356_ASP GLY gnomAD
chr1:104166498
rs552900947
- 0.000122784 -
361_PRO THR 8.3kJPN
chr1:104166512
-
- 0.0001 -
367_ILE MET gnomAD
chr1:104120156
rs181502776
- 0.000343026 -
367_ILE MET 8.3kJPN
chr1:104120156
rs181502776
- 0.0023 -
372_ILE MET gnomAD
chr1:104166547
rs760606304
- 0.00157031 -
372_ILE MET 8.3kJPN
chr1:104166547
rs760606304
- 0.0173 -
381_ASP GLU 8.3kJPN
chr1:104166574
-
- 0.0003 -
382_TRP CYS 8.3kJPN
chr1:104120201
-
- 0.0003 -
382_TRP CYS 8.3kJPN
chr1:104166577
-
- 0.0007 -
387_ARG GLY gnomAD
chr1:104166590
rs1832269
- 0.000596638 -
387_ARG GLY 8.3kJPN
chr1:104166590
rs1832269
- 0.0001 -
389_ARG CYS gnomAD
chr1:104166596
rs777496434
- 0.000105419 -
389_ARG HIS gnomAD
chr1:104166597
rs770294712
- 0.000289424 -
389_ARG HIS 8.3kJPN
chr1:104120221
rs753265856
- 0.0001 -
389_ARG HIS 8.3kJPN
chr1:104166597
rs770294712
- 0.0004 -
389_ARG CYS 8.3kJPN
chr1:104205387
rs1240333808
- 0.0004 -
391_ILE THR gnomAD
chr1:104120227
rs151132065
- 0.0143186 -
391_ILE VAL 8.3kJPN
chr1:104205393
rs1178161506
- 0.0001 -
394_MET ILE 8.3kJPN
chr1:104120348
-
- 0.0001 -
398_ARG HIS 8.3kJPN
chr1:104166735
rs1274019006
- 0.0005 -
398_ARG HIS 8.3kJPN
chr1:104205525
rs1257528856
- 0.0002 -
404_GLN HIS gnomAD
chr1:104120378
rs150269811
- 0.000529374 -
404_GLN HIS 8.3kJPN
chr1:104166754
-
- 0.0001 -
405_PRO ALA 8.3kJPN
chr1:104166755
-
- 0.0001 -
420_GLY ARG 8.3kJPN
chr1:104166800
-
- 0.0001 -
422_GLY ARG 8.3kJPN
chr1:104205596
-
- 0.0002 -
430_ASN SER gnomAD
chr1:104120455
rs370179572
- 0.00064088 -
433_ASP TYR 8.3kJPN
chr1:104166839
rs1231626541
- 0.0001 -
449_TYR ASN 8.3kJPN
chr1:104206996
-
- 0.0003 -
469_VAL ALA 8.3kJPN
chr1:104207057
-
- 0.0004 -
472_ASP ASN gnomAD
chr1:104122045
rs150795802
- 0.000199168 -
477_PHE SER gnomAD
chr1:104122061
rs145989588
- 0.00023903 -
490_ILE THR 8.3kJPN
chr1:104207120
-
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.