PDB ID 1BCC     CHAIN E
Protein name UBIQUINOL CYTOCHROME C OXIDOREDUCTASE
Uniprot Accession P13272
The number of similar proteins 35
The number of binding states 6
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BCC (CHAIN: E)
1 2BCC   2BCC   2BCC   P18946   2BCC  
2 Monomeric state
3 P00157  
4 P00130   P13271   P00125   P00157   P31800   P07552  
5 P00130   P13271   P00125   P00157   P00157   P31800  
6 P00130   P13271   P00125   P00157   P00157   P31800   P07552  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   SHTDIKVPNF   SDYRRPPDDY   STKSSRESDP   SRKGFSYLVT   AVTTLGVAYA   50
51   AKNVVTQFVS   SMSASADVLA   MSKIEIKLSD   IPEGKNMAFK   WRGKPLFVRH   100
101   RTKKEIDQEA   AVEVSQLRDP   QHDLERVKKP   EWVILIGVCT   HLGCVPIANA   150
151   GDFGGYYCPC   HGSHYDASGR   IRKGPAPLNL   EVPSYEFTSD   DMVIVG   200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
14_ARG CYS gnomAD
chr19:29699006 		rs185606879
- 0.000466184 -
15_ARG HIS 8.3kJPN
chr19:29699002 		rs148167893
- 0.0001 -
15_ARG CYS 8.3kJPN
chr19:29699003 		rs201270947
- 0.0002 -
26_ARG GLY 8.3kJPN
chr19:29698970 		rs547606246
- 0.0001 -
37_TYR CYS 8.3kJPN
chr19:29698936 		rs1349344134
- 0.0001 -
48_ALA THR gnomAD
chr19:29698904 		rs146164627
- 0.000163427 -
77_LYS THR 8.3kJPN
chr19:29698816 		rs201719321
- 0.0071 -
94_LYS ARG 8.3kJPN
chr19:29698765 		rs1316471601
- 0.0001 -
107_GLU LYS 8.3kJPN
chr19:29698727 		rs753161122
- 0.0027 -
126_ARG TER ClinVar
chr19:29698670 		rs1242465339
Pathogenic - Lactic acidosis [Human Phenotype Ontology:HP:0003128,Human Phenotype Ontology:HP:0003255,Human Phenotype Ontology:HP:0005960,MONDO:MONDO:0006040,MedGen:C0001125]; Cardiomyopathy [Human Phenotype Ontology:HP:0001638,MONDO:MONDO:0004994,MedGen:C0878544,Orphanet:167848]; Propionic acidemia|Mitochondrial complex 3 deficiency, nuclear type 10 [Human Phenotype Ontology:HP:0003571,MONDO:MONDO:0011628,MedGen:C0268579,OMIM:606054,Orphanet:35|MONDO:MONDO:0032909,MedGen:C5394051,OMIM:618775]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.